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Cystic Lesions

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Benign Breast Diseases

Abstract

Several terms have been applied to the condition of fibrocystic change, including mammary dysplasia, fibrocystic disease, cystic mastopathy and cystic hyperplasia.

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References

  • Agnantis NJ, Mahera H, Maounis N, Spandidos DA (1992) Immunohistochemical study of ras and myc oncoproteins in apocrine breast lesions with and without papillomatosis. Eur J Gynaecol Oncol 13:309–315

    CAS  PubMed  Google Scholar 

  • Ahmed A (1975) Apocrine metaplasia in cystic mastopathy. Histochemical and ultrastructural observations. J Pathol 115:211–214

    Article  CAS  PubMed  Google Scholar 

  • Azzopardi JG (1979) Cystic disease; duct ectasia; fat necrosis; fibrous disease of the breast. In: Problems in breast pathology. WB Saunders Company Ltd. London: Philadelphia Toronto, pp 57–91

    Google Scholar 

  • Boyle CA, Berkowitz GS, LiVolsi VA et al (1984) Caffeine consumption and fibrocystic breast disease: a case–control epidemiologic study. J Natl Cancer Inst 72:1015–1019

    CAS  PubMed  Google Scholar 

  • Ciatto S, Cariaggi P, Bulgaresi P (1987) The value of routine cytologic examination of breast cyst fluids. Acta Cytol 31:301–304

    CAS  PubMed  Google Scholar 

  • Dawson EK (1932) Sweat gland carcinoma of the breast. A morpho-histological study. Edinb Med J 39:409–438

    Google Scholar 

  • Doshi DJ, March DE, Giovanna MC et al (2007) Complex cystic breast masses: diagnostic approach and imaging – pathologic correlation. Radiographics 27:553–564

    Article  Google Scholar 

  • Drukker BH, deMendonca WC (1987) Fibrocystic change and fibrocystic disease of the breast. Obstet Gynecol Clin North Am 14:685–702

    CAS  PubMed  Google Scholar 

  • Dupont WD, Page DL (1985) Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med 312:146–151

    Article  CAS  PubMed  Google Scholar 

  • Eusebi V, Millis RR, Cattani MG, Bussolati G, Azzopardi JG (1986) Apocrine carcinoma of the breast. A morphologic and immunohistochemical study. Am J Pathol 123:532–541

    CAS  PubMed  Google Scholar 

  • Fitzgibbons PL, Henson DE, Hutter RVP (1998) Benign breast changes and the risk for subsequent breast cancer. Arch Pathol Lab Med 122:1053–1055

    CAS  PubMed  Google Scholar 

  • Foote FW, Stewart FW (1945) Comparative studies of cancerous versus noncancerous breasts. I. Basic morphological characteristics. Ann Surg 121:6–53

    Article  CAS  PubMed  Google Scholar 

  • Forrest AP, Kirkpatrick JR, Roberts MM (1975) Needle aspiration of breast cysts. Br Med J 3:30–31

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Frantz VK, Pickren JW, Melcher GW, Auchincloss H (1951) Incidence of chronic cystic breast disease in so-called normal breast. Cancer 4:762–783

    Article  CAS  PubMed  Google Scholar 

  • Gatalica Z (1997) Immunohistochemical analysis of apocrine breast lesions. Consistent overexpression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ. Pathol Res Pract 193:753–758

    Article  CAS  PubMed  Google Scholar 

  • Haagensen CD (1986) Apocrine epithelium. In: Diseases of the breast. Saunders, Philadelphia, pp 82–101

    Google Scholar 

  • Haagensen DE Jr (1991) Is cystic disease related to breast cancer. Am J Surg Pathol 15:687–694

    Article  PubMed  Google Scholar 

  • Haagensen DE Jr, Mazoujian GM, Dilley WG, Pedersen CE, Kister SJ, Wells SA Jr (1979) Breast gross cystic disease fluid analysis. I. Isolation and radioimmunoassay for a major component protein. J Natl Cancer Inst 62:239–247

    CAS  PubMed  Google Scholar 

  • Heywang-Köbrunner SH, Dershaw DD, Schreer I (2001) Cysts; inflammatory conditions. In: Diagnostic breast imaging. Thieme, Stuttgart/New York, pp 197–208; 236–251

    Google Scholar 

  • Hutter RVP et al (1986) Is “fibrocystic disease” of the breast precancerous. Arch Pathol Lab Med 110:171–173

    Google Scholar 

  • Jones BM, Bradbeer JW (1980) Presentation and progress of macroscopic breast cysts. Br J Surg 67:669–671

    Article  CAS  PubMed  Google Scholar 

  • Jones C, Damiani S, Wells D, Chaggar R, Lakhani SR, Eusebi V (2001) Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast. Am J Pathol 158:207–214

    Article  CAS  PubMed  Google Scholar 

  • Kushwaha AC, O’Toole M, Sneige N, Stelling CB, Dryden MJ (2003) Mammographic–pathologic correlation of apocrine metaplasia diagnosed using vacuum-assisted stereotactic core-needle biopsy: our 4-year experience. Am J Roentgenol 180:795–798

    Article  Google Scholar 

  • Lanyi M (2003) Lesions of the terminal ducts and lobules. In: Mammography, diagnosis and pathological analysis. New York: Springer, Berlin Heidelberg, pp 28–79

    Google Scholar 

  • Lendrum AC (1945) On the “pink” epithelium of the cystic breast and staining of its granules. J Pathol Bacteriol 57:267–270

    Article  Google Scholar 

  • Love SM, Gelman RS, Silen W (1982) Fibrocystic “disease” of the breast – a nondisease. N Engl J Med 307:1010–1014

    Article  CAS  PubMed  Google Scholar 

  • Mansel RI, Webster DJT, Sweetland HM (eds) (2009) Cysts of the breast. In: Benign disorders and diseases of the breast, 3rd edn. China: Saunders Elsevier, pp 147–162

    Google Scholar 

  • Mazoujian G, Pinkus GS, Davis S, Haagensen DE Jr (1983) Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. Am J Pathol 110:105–112

    CAS  PubMed  Google Scholar 

  • Minton JP, Foecking MK, Webster DJ, Matthews RH (1979a) Caffeine, cyclic nucleotides, and breast disease. Surgery 86:105–109

    CAS  PubMed  Google Scholar 

  • Minton JP, Foecking MK, Webster DJ, Matthews RH (1979b) Response of fibrocystic disease to caffeine withdrawal and correlation of cyclic nucleotides with breast disease. Am J Obstet Gynecol 135:157–158

    CAS  PubMed  Google Scholar 

  • Ozzello L (1971) Ultrastructure of the human mammary gland. Pathol Annu 6:1–59

    CAS  PubMed  Google Scholar 

  • Page DL, Vander Zwaag R, Rogers LW, Williams LT, Walker WE, Hartmann WH (1978) Relation between component parts of fibrocystic disease complex and breast cancer. J Natl Cancer Inst 61:1055–1063

    CAS  PubMed  Google Scholar 

  • Page DL, Dupont WD, Jensen RA (1996) Papillary apocrine change of the breast: associations with atypical hyperplasia and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 5:29–32

    CAS  PubMed  Google Scholar 

  • Selim AG, Wells CA (1999) Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis of the breast: relation to estrogen and progesterone receptors. J Clin Pathol 52:838–841

    Article  CAS  PubMed  Google Scholar 

  • Shaaban AM, O’Neill PA, Davies MPA et al (2003) Declining estrogen receptor-β expression defines malignant progression of human breast neoplasia. Am J Surg Pathol 27:1502–1512

    Article  PubMed  Google Scholar 

  • Simard J, Hatton AC, Labrie C et al (1989) Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75–1 human breast cancer cells. Mol Endocrinol 3:694–702

    Article  CAS  PubMed  Google Scholar 

  • Simard J, Dauvois S, Haagensen DE, Levesque C, Merand Y, Labrie F (1990) Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer. Endocrinology 126:3223–3231

    Article  CAS  PubMed  Google Scholar 

  • Slack JM (1986) Epithelial metaplasia and the second anatomy. Lancet 2:268–271

    Article  CAS  PubMed  Google Scholar 

  • Tabár L, Dean PD (1985) Circumscribed lesions; calcifications. In: Teaching atlas of mammography. Georg Thieme Verlag, Stuttgart/New York, p 18, 172–210

    Google Scholar 

  • Tabár L, Pentek Z, Dean PB (1981) The diagnostic and therapeutic value of breast cyst puncture and pneumocystography. Radiology 141:659–663

    PubMed  Google Scholar 

  • Viacava P, Naccarato AG, Bevilacqua G (1997) Apocrine epithelium of the breast: does it result from metaplasia. Virchows Arch 431:205–209

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Constantino JP, Tan-Chic E et al (2004) Lower-category benign breast disease and risk of invasive breast cancer. J Natl Cancer Inst 96:616–620

    Article  PubMed  Google Scholar 

  • Warner JK, Kumar D, Berg WA (1998) Apocrine metaplasia: mammographic and sonographic appearances. Am J Roentgenol 170:1375–1379

    Article  CAS  Google Scholar 

  • Washington C, Dalbègue F, Abreo F, Taubenberger JK, Lichy JH (2000) Loss of heterozygosity in fibrocystic change of the breast: genetic relationship between benign proliferative lesions and associated carcinomas. Am J Pathol 157:323–329

    Article  CAS  PubMed  Google Scholar 

  • Wellings SR, Alpers CE (1987) Apocrine cystic metaplasia: subgross pathology and prevalence in cancer-associated versus random autopsy breasts. Hum Pathol 18:381–386

    Article  CAS  PubMed  Google Scholar 

  • Wick MR, Lillemoe TJ, Copland GT, Swanson PE, Manivel JC, Kiang DT (1989) Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. Hum Pathol 20:281–287

    Article  CAS  PubMed  Google Scholar 

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Chinyama, C.N. (2014). Cystic Lesions. In: Benign Breast Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41065-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-41065-9_7

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