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Inorganic Polymers: Morphogenic Inorganic Biopolymers for Rapid Prototyping Chain

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Biomedical Inorganic Polymers

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 54))

Abstract

In recent years, considerable progress has been achieved towards the development of customized scaffold materials, in particular for bone tissue engineering and repair, by the introduction of rapid prototyping or solid freeform fabrication techniques. These new fabrication techniques allow to overcome many problems associated with conventional bone implants, such as inadequate external morphology and internal architecture, porosity and interconnectivity, and low reproducibility. However, the applicability of these new techniques is still hampered by the fact that high processing temperature or a postsintering is often required to increase the mechanical stability of the generated scaffold, as well as a post-processing, i.e., surface modification/functionalization to enhance the biocompatibility of the scaffold or to bind some bioactive component. A solution might be provided by the introduction of novel inorganic biopolymers, biosilica and polyphosphate, which resist harsh conditions applied in the RP chain and are morphogenetically active and do not need supplementation by growth factors/cytokines to stimulate the growth and the differentiation of bone-forming cells.

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Acknowledgments

W.E.G.M. is a holder of an ERC Advanced Investigator Grant (no. 268476 BIOSILICA) as well as of an ERC proof-of-concept grant (no. 324564; Silica-based nanobiomedical approaches for treatment of bone diseases). This work was supported by grants from the European Commission (FP7-NMP-2013-EU-CHINA project no. 604036—Bio-Scaffolds; large-scale integrating project, project no. 311848—BlueGenics; project no. FP7-KBBE-2010-4-266033—SPECIAL; project no. PIRSES-GA-2009-246987—European-Chinese Research Staff Exchange Cluster MarBioTec*EU-CN*), the German Bundesministerium für Bildung und Forschung—International Bureau (no. CHN 09/1AP—German-Chinese Joint Lab on Bio-Nano-Composites), the Public Welfare Project of Ministry of Land and Resources of the People’s Republic of China (grant no. 201011005–06), and the International S & T Cooperation Program of China (grant no. 2008DFA00980).

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Authors and Affiliations

  1. ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany

    Werner E. G. Müller, Heinz C. Schröder & Xiaohong Wang

  2. NanotecMARIN GmbH, Duesbergweg 6, 55128, Mainz, Germany

    Werner E. G. Müller & Heinz C. Schröder

  3. Department of Materials Science and Engineering, Tsinghua University, Beijing, 100084, People’s Republic of China

    Zhijian Shen & Qingling Feng

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  1. Werner E. G. Müller
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  2. Heinz C. Schröder
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  3. Zhijian Shen
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  4. Qingling Feng
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  5. Xiaohong Wang
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Correspondence to Werner E. G. Müller .

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Editors and Affiliations

  1. ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    Werner E. G. Müller

  2. ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    Xiaohong Wang

  3. ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    Heinz C. Schröder

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Müller, W.E.G., Schröder, H.C., Shen, Z., Feng, Q., Wang, X. (2013). Inorganic Polymers: Morphogenic Inorganic Biopolymers for Rapid Prototyping Chain. In: Müller, W., Wang, X., Schröder, H. (eds) Biomedical Inorganic Polymers. Progress in Molecular and Subcellular Biology, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41004-8_9

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