Abstract
Fibroblasts are the main cell type of dermal connective tissue in addition to scarce histiocytes and mast cells. The major function of fibroblasts is collagen synthesis. A subset of benign tumors and reactive processes show an increase of fibroblasts and histiocytes in addition to collagen and elastic fibers. A great number of benign tumors and proliferations of fibrous tissue of skin and tendons will be discussed in this chapter. Some of them, such as acrochordon and keloid, are very common. Most show benign biological behavior without malignant transformation, but some tumors may be locally invasive. Juvenile hyaline fibromatosis, which clinically presents as tumoral lesions, is in fact not a neoplasm but related to the deposition of an extracellular matrix substance. It is included in this chapter. Diseases characterized by mast cell proliferation will be discussed in another chapter.
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Baykal, C., Yazganoğlu, K.D. (2014). Benign Fibrohistiocytic Tumors and Proliferations. In: Clinical Atlas of Skin Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40938-7_8
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DOI: https://doi.org/10.1007/978-3-642-40938-7_8
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