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Orbital Vascular Tumors

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Clinical Ophthalmic Oncology

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Abstract

Orbital vascular lesions may be neoplastic such as capillary and cavernous hemangioma, which expand by cellular proliferation, or anomalies representing varying types and degrees of vascular dysgenesis, or malformations. Until recently, no consensus existed among ophthalmologists to classify the types of lesions falling under the malformation category. In response, The Orbital Society created a classification system for orbital vascular malformations in 1999 to establish a standardized classification system and to reduce clinical confusion surrounding the management of these entities. This system classifies malformations based on hemodynamic behavior as opposed to their morphologic characteristics emphasizing the features most important to their management. Clinical and imaging findings are used to assign orbital vascular malformations as no flow, venous flow, or arterial flow, and the term “lymphangioma” was identified as inaccurate as these lesions lack both a true neoplastic origin. Under the new classification system, they are “no-flow” malformations, which are hemodynamically isolated.

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References

  1. Harris GJ. Orbital vascular malformations: a consensus statement on terminology and its clinical implications. Am J Ophthalmol. 1999;127(4):453–5.

    Article  PubMed  CAS  Google Scholar 

  2. Aletaha M, Salour H, Bagheri A, et al. Successful treatment of orbital hemangioma with propranolol in a 5-year-old girl. Orbit. 2012;31(1):18–20.

    Article  PubMed  Google Scholar 

  3. Taban M, Goldberg RA. Propranolol for orbital hemangioma. Ophthalmology. 2010;117(1):195–5.e4.

    Google Scholar 

  4. Hill RH, Shiels WE, Foster JA, et al. Percutaneous drainage and ablation as first line therapy for macrocystic and microcystic orbital lymphatic malformations. Ophthal Plast Reconstr Surg. 2012;28(2):119–25.

    Article  PubMed  Google Scholar 

  5. Greene AK, Burrows PE, Smith L, Mulliken JB. Periorbital lymphatic malformation: clinical course and management in 42 patients. Plast Reconstr Surg. 2005;115(1):22–30.

    PubMed  CAS  Google Scholar 

  6. Hall N, Ade-Ajai N, Pierro A, et al. Is intralesional injection of OK-432 effective in the treatment of lymphangioma in children? Surgery. 2003;133:238–42.

    Article  PubMed  Google Scholar 

  7. Boulos PR, Harissi-Dagher M, Kavalec C, Hardy I, Codere F. Intralesional injection of Tisseel fibrin glue for resection of lymphangiomas and other thin-walled orbital cysts. Ophthal Plast Reconstr Surg. 2005;21(3):171–6.

    Article  PubMed  Google Scholar 

  8. Werner JA, Dunne AA, Folz BJ, Rochels R, Bien S, Ramaswamy A, Lippert BM. Current concepts in the classification, diagnosis and treatment of hemangiomas and vascular malformations of the head and neck. Eur Arch Otorhinolaryngol. 2001;258(3):141–9.

    Article  PubMed  CAS  Google Scholar 

  9. Ernemann U, Westendorff C, Troitzsch D, et al. Navigation-assisted sclerotherapy of orbital veno-lymphatic malformation: a new guidance technique for percutaneous treatment of low-flow vascular malformations. AJNR Am J Neuroradiol. 2004;25(10):1792–5.

    PubMed  Google Scholar 

  10. Hayashi N, Masumoto T, Okubo T, et al. Hemangiomas in the face and extremities. De Lorimier AA. Sclerotherapy for venous malformations. J Pediatr Surg. 1995;30:188–93.

    Article  Google Scholar 

  11. Lee CH, Chen SG. Direct percutaneous ethanol sclerotherapy for treatment of a recurrent venous malformation in the periorbital region. ANZ J Surg. 2004;74(12):1126–7.

    Article  PubMed  Google Scholar 

  12. Goldberg RA, Garcia GH, Duckwiler GR. Combined embolization and surgical treatment of arteriovenous malformation of the orbit. Am J Ophthalmol. 1993;116:17–25.

    PubMed  CAS  Google Scholar 

  13. Hayes BH, Shore JW, Westfall CT, Harris GJ. Management of orbital and periorbital arteriovenous malformations. Ophthalmic Surg. 1995;26(2):145–52.

    PubMed  CAS  Google Scholar 

  14. Lee BB, Do YS, Yakes W, et al. Management of arteriovenous malformations: a multidisciplinary approach. J Vasc Surg. 2004;39:590–600.

    Article  PubMed  Google Scholar 

  15. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69(3):412–22.

    Article  PubMed  CAS  Google Scholar 

  16. Coats DK, Paysse EA, Levy ML. PHACE: a neurocutaneous syndrome with important ophthalmologic implications: case report and literature review. Ophthalmology. 1999;106:1739–41.

    Article  PubMed  CAS  Google Scholar 

  17. Walter JW, Blei F, Anderson JL, Orlow SJ, Speer MC, Marchuk DA. Genetic mapping of a novel familial form of infantile hemangioma. Am J Med Genet. 1999;82:77–83.

    Article  PubMed  CAS  Google Scholar 

  18. Shields CL, Shields JA, Minzter R, et al. Cutaneous capillary hemangiomas of the eyelid, scalp, and digits in premature triplets. Am J Ophthalmol. 2000;129(4):528–31.

    Article  PubMed  CAS  Google Scholar 

  19. Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med. 1999;341:173–81.

    Article  PubMed  CAS  Google Scholar 

  20. Marler JJ, Fishman SJ, Kilroy SM, Fang J, Upton J, Mulliken JB, Burrows PE, Zurakowski D, Folkman J, Moses MA. Increased expression of urinary matrix metalloproteinases parallels the extent and activity of vascular anomalies. Pediatrics. 2005;116(1):38–45.

    Article  PubMed  Google Scholar 

  21. Berman B, Poochareon VN, Villa AM. Novel dermatologic uses of the immune response modifier imiquimod 5 % cream. Skin Therapy Lett. 2002;7:1–10.

    PubMed  CAS  Google Scholar 

  22. Clymer MA, Fortune DS, Reinisch L, Toriumi DM, Werkhaven JA, Ries WR. Interstitial Nd:YAG photocoagulation for vascular malformations and hemangiomas in childhood. Arch Otolaryngol Head Neck Surg. 1998;124(4):431–6.

    Article  PubMed  CAS  Google Scholar 

  23. North PE, Waner M, Mizeraki A, Mihm MC. GLUT 1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol. 2000;31:11–22.

    Article  PubMed  CAS  Google Scholar 

  24. Neumann D, Isenberg SJ, Rosenbaum AL, Goldberg RA, Jotterand VH. Ultrasonographically guided injection of corticosteroids for the treatment of retroseptal capillary hemangiomas in infants. J AAPOS. 1997;1(1):34–40.

    Article  PubMed  CAS  Google Scholar 

  25. Egbert JE, Paul S, Engel WK, Summers CG. High injection pressure during intralesional injection of corticosteroids into capillary hemangiomas. Arch Ophthalmol. 2001;119(5):677–83.

    Article  PubMed  CAS  Google Scholar 

  26. Egbert JE, Schwartz GS, Walsh AW. Diagnosis and treatment of an ophthalmic artery occlusion during an intralesional injection of corticosteroid into an eyelid capillary hemangioma. Am J Ophthalmol. 1996;121(6):638–42.

    PubMed  CAS  Google Scholar 

  27. Goyal R, Watts P, Lane CM, Beck L, Gregory JW. Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma. Ophthalmology. 2004;111(2):389–95.

    Article  PubMed  Google Scholar 

  28. Coats DK, O’Neil JW, Paysse EA, et al. SubTenon’s infusion of steroids for treatment of orbital hemangiomas. Ophthalmology. 2003;110:1255–9.

    Article  PubMed  Google Scholar 

  29. Ezekowitz RA, Mulliken JB, Folkman J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med. 1992;326:1456–63.

    Article  PubMed  CAS  Google Scholar 

  30. Kodama T, Tane N, Ohira A, Matsuoka Y, Maruyama R. Concomitant cavernous hemangioma and venous angioma of the orbit. Jpn J Ophthalmol. 2004;48(4):415–7.

    PubMed  Google Scholar 

  31. Gelal F, Feran H, Rezanko T, Vidinli BD. Giant cavernous angioma of the temporal lobe: a case report and review of the literature. Acta Radiol. 2005;46(3):310–3.

    Article  PubMed  CAS  Google Scholar 

  32. Di Tommaso L, Scarpellini F, Salvi F, Ragazzini T, Foschini MP. Progesterone receptor expression in orbital cavernous hemangiomas. Virchows Arch. 2000;436(3):284–8.

    Article  PubMed  Google Scholar 

  33. Gdal-On M, Israel O. Cryoextraction of orbital hemangiomas diagnosed by Tc-99M-labeled red blood cells. Vision Res. 1995;35:169.

    Article  Google Scholar 

  34. McNab AA, Wright JE. Cavernous haemangiomas of the orbit. Aust N Z J Ophthalmol. 1989;17:337–45.

    Article  PubMed  CAS  Google Scholar 

  35. Kiratli H, Bulur B, Bilgic S. Transconjunctival approach for retrobulbar intraconal orbital cavernous hemangiomas. Orbital surgeon’s perspective. Surg Neurol. 2005;64(1):71–4.

    Article  PubMed  Google Scholar 

  36. Karcioglu ZA, Nasr AM, Haik BG. Orbital hemangiopericytoma: clinical and morphologic features. Am J Ophthalmol. 1997;124(5):661–72.

    PubMed  CAS  Google Scholar 

  37. Croxatto JO, Font RL. Hemangiopericytoma of the orbit: a clinicopathologic study of 30 cases. Hum Pathol. 1982;13:210–8.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Ophthalmology, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue I-32, Cleveland, OH, 44195, USA

    Bryan R. Costin MD & Julian D. Perry MD

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  1. Bryan R. Costin MD
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  2. Julian D. Perry MD
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Correspondence to Julian D. Perry MD .

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Editors and Affiliations

  1. Division of Opthalmology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Julian D. Perry

  2. Department of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Arun D. Singh

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© 2014 Springer-Verlag Berlin Heidelberg

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Costin, B.R., Perry, J.D. (2014). Orbital Vascular Tumors. In: Perry, J., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40492-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-40492-4_7

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