Skip to main content
SpringerLink
Log in

Lacrimal Gland Tumors

  • Chapter
  • First Online:
Clinical Ophthalmic Oncology

  • 1073 Accesses

Abstract

While 9–15 % of orbital tumors arise in lacrimal gland, inflammatory or infiltrative diseases – such as sarcoidosis, Wegener’s granulomatosis, IgG4 disease, or other (nonspecific) dacryoadenitis – comprise two-thirds of lacrimal gland masses and can present with signs and symptoms similar to tumors. Often a firm diagnosis can be reached only with tissue biopsy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Shields JA, Shields CL, Epstein JA, Scartozzi R, Eagle RC. Primary epithelial malignancies of the lacrimal gland: the 2003 Ramon L. Font Lecture. Ophthalmic Plast Reconstr J. 2004;20:10–21.

    Article  Google Scholar 

  2. Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, part 1. Ophthalmology. 2004;111:997–1008.

    Article  PubMed  Google Scholar 

  3. Jenkins C, Rose GE, Bunce C, et al. Clinical features associated with survival of patients with lymphoma of the ocular adnexa. Eye. 2003;17:809–20.

    Article  PubMed  CAS  Google Scholar 

  4. Rose GE, Wright JE. Pleomorphic adenoma of the lacrimal gland. Br J Ophthalmol. 1992;76:395–400.

    Article  PubMed  CAS  Google Scholar 

  5. Wright JE, Rose GE, Garner A. Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmol. 1992;76:401–7.

    Article  PubMed  CAS  Google Scholar 

  6. Rootman J, White V, Hind A. Tumors of the lacrimal gland. In: Rootman J, editor. Disease of the orbit. A multidisciplinary approach. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2003.

    Google Scholar 

  7. Cates CA, Manners RM, Rose GE. Pleomorphic adenoma of the lacrimal gland in a 10 year old girl. Br J Ophthalmol. 2002;86:249–50.

    Article  PubMed  Google Scholar 

  8. Vangveeravong S, Katz SE, Rootman J, White V. Tumors arising in the palpebral lobe of the lacrimal gland. Ophthalmology. 1996;103:1606–12.

    Article  PubMed  CAS  Google Scholar 

  9. Aviv RI, Miszkiel K. Orbital imaging: part 2. Intraorbital pathology. Clin Radiol. 2005;60:288–307.

    Article  PubMed  CAS  Google Scholar 

  10. Rose GE. To crash or not to crash? Probability in the management of benign lacrimal gland tumours. Eye. 2009;23:1625–8.

    Article  PubMed  Google Scholar 

  11. Prabhakaran VC, Cannon PS, McNab A, et al. Lesions mimicking lacrimal gland pleomorphic adenoma. Br J Ophthalmol. 2010;94:1509–12.

    Article  PubMed  Google Scholar 

  12. Kopp ED, Sahlin S, Tani E, Skoog L, Seregard S. Fine- needle aspiration biopsy in lacrimal gland pleomorphic adenoma. Eye. 2010;24:386–9.

    Article  PubMed  CAS  Google Scholar 

  13. Perzin KH, Jakobiec FA, Livolsi VA, Desjardins L. Lacrimal gland malignant mixed tumors (carcinomas arising in benign mixed tumors): a clinico-pathologic study. Cancer. 1980;45:2593–606.

    Article  PubMed  CAS  Google Scholar 

  14. Currie ZI, Rose GE. Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol. 2007;125:1643–6.

    Article  PubMed  Google Scholar 

  15. Ni C, Kuo PK, Dryja TP. Histopathological classification of 272 primary epithelial tumors of the lacrimal gland. Chin Med J (Engl). 1992;105:481–5.

    CAS  Google Scholar 

  16. Rose GE, Wright JE. Exenteration for benign orbital disease. Br J Ophthalmol. 1994;78:14–8.

    Article  PubMed  CAS  Google Scholar 

  17. Skinner HD, Garden AS, Rosenthal DI, et al. Outcomes of malignant tumors of the lacrimal apparatus. Cancer. 2011;117:2801–10.

    Article  PubMed  Google Scholar 

  18. Meldrum ML, Tse DT, Benedetto P. Neoadjuvant intracarotid chemotherapy for treatment of advanced adenocystic carcinoma of the lacrimal gland. Arch Ophthalmol. 1998;116:315–21.

    Article  PubMed  CAS  Google Scholar 

  19. Tse DT, Benedetto P, Dubovy S, Schiffman JC, Feuer WJ. Clinical analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. Am J Ophthalmol. 2006;141:44–53.

    Article  PubMed  CAS  Google Scholar 

  20. Le Tourneau C, Razak ARA, Levy C, et al. Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland. Br J Ophthalmol. 2011;95:1483–9.

    Article  PubMed  Google Scholar 

  21. Esmaeli B, Ahmadi MA, Youssef A, et al. Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg. 2004;20:22–6.

    Article  PubMed  Google Scholar 

  22. Heaps RS, Miller NR, Albert DM, et al. Primary adenocarcinoma of the lacrimal gland. A retrospective study. Ophthalmology. 1993;100:1856–60.

    Article  PubMed  CAS  Google Scholar 

  23. Font RL, Gamel JW. Epithelial tumors of the lacrimal gland: an analysis of 265 cases. In: Jakobiec FA, editor. Ocular and adnexal tumors. Birmingham: Aesculapius; 1978. p. 787–805.

    Google Scholar 

  24. El-Sawy T, Savar A, Williams MD, De Monte F, Esmaili B. Prognostic accuracy of the seventh edition vs sixth edition of the American Joint Committee on cancer tumor classification for adenoid cystic carcinoma of the lacrimal gland. Arch Ophthalmol. 2012;130:664–6.

    PubMed  Google Scholar 

  25. Jenkins C, Rose GE, Bunce C, et al. Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival. Br J Ophthalmol. 2000;84:907–13.

    Article  PubMed  CAS  Google Scholar 

  26. Tse D. Clinical and microdissection genotyping analyses of the effect of intra-arterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. Trans Am Ophthalmol Soc. 2005;103:337–67.

    PubMed  Google Scholar 

  27. Persson M, Andren Y, Mark J, Horlings HM, Persson F, Stenman G. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci. 2009;106:18740–4.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oculoplastic and Orbital Service, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK

    David H. Verity & Geoffrey E. Rose DSc, MS, FRCS, FRCOphth

  2. Oculoplastic and Orbital Service, Birmingham and Midland Eye Centre, City Hospital NHS Trust, Dudley Road, Birmingham, West Midlands, B18 7QH, UK

    Omar M. Durrani

Authors
  1. David H. Verity
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Omar M. Durrani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Geoffrey E. Rose DSc, MS, FRCS, FRCOphth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Geoffrey E. Rose DSc, MS, FRCS, FRCOphth .

Editor information

Editors and Affiliations

  1. Division of Opthalmology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Julian D. Perry

  2. Department of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Arun D. Singh

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Verity, D.H., Durrani, O.M., Rose, G.E. (2014). Lacrimal Gland Tumors. In: Perry, J., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40492-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-40492-4_10

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40491-7

  • Online ISBN: 978-3-642-40492-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation