Skip to main content
SpringerLink
Log in

Biosensor Signal Transducers

  • Chapter
  • First Online:
Biosensors: Essentials

Part of the book series: Lecture Notes in Chemistry ((LNC,volume 84))

Abstract

Electrochemical biosensors utilize measurement technologies widely represented in most (bio)chemical laboratories and discussed in most monographs and student books. Thus, the potentiometric biosensors are compatible with pH- and ionometers and voltammetric (amperometric) biosensors with oximeters and voltammographs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adeloju SB, Shaw SJ, Wallace GG (1996) Polypyrrole based amperometric flow-injection biosensor for urea. Anal Chim Acta 323:107–113

    Article  CAS  Google Scholar 

  • Alfonta L, Willner I, Throckmorton DJ, Singh AK (2001) Electrochemical and quartz crystal microbalance detection of the cholera toxin employing horseradish peroxidase and GM1-functionalized liposomes. Anal Chem 73:5287–5295

    Google Scholar 

  • Ammida NHS, Micheli L, Palleschi G (2004) Electrochemical immunosensor for determination of aflatoxin B1 in barley. Anal Chim Acta 520:159–164

    Article  CAS  Google Scholar 

  • Arora A, de Mello AJ, Manz A (1007) Sub-microliter electrochemiluminescence detector—A model for small volume analysis systems. Anal Commun 34:393–395

    Article  Google Scholar 

  • Bakker E, Pretsch E (2007) Modern potentiometry. Angew Chem 46:5660–5668

    Article  CAS  Google Scholar 

  • Bakker E, Pretsch E, Bühlmann P (2000) Selectivity of potentiometric ion sensors. Anal Chem 72:1127–1133

    Article  CAS  Google Scholar 

  • Balkenhohl T, Lisdat F (2007a) Screen-printed electrodes as impedimetric immunosensors for the detection of anti-transglutaminase antibodies in human sera. Anal Chim Acta 597:50–57

    Article  CAS  Google Scholar 

  • Balkenhohl T, Lisdat F (2007b) An impedimetric immunosensor for the detection of autoantibodies directed against gliadins. Analyst 132:314–322

    Article  CAS  Google Scholar 

  • Bard AJ, Faulkner LR (2001) Electrochemical methods. fundamentals and applications (2nd edn). Wiley and Sons Inc, New York

    Google Scholar 

  • Baur J, Gondran C, Holzinger M, Defrancq E, Perrot H, Cosnier S (2010a) Label-free femtomolar detection of target DNA by impedimetric DNA sensor based on poly(pyrrole-nitrilotriacetic acid) film. Anal Chem 82:1066–1072

    Article  CAS  Google Scholar 

  • Baur J, Gondran C, Holzinger M, Defrancq E, Perrot E, Cosnier S (2010b) Label-free femtomolar detection of target DNA by impedimetric DNA sensor based on poly(pyrrole-nitrilotriacetic acid) film. Anal Chem 82:1066–1072

    Article  CAS  Google Scholar 

  • Bergveld P (2003) Thirty years of ISFETOLOGY. What happened in the past 30 years and what may happen in the next 30 years. Sens Actuators, B 88:1–20

    Article  CAS  Google Scholar 

  • Bizzarri AR, Cannistraro S (2007) SERS detection of thrombin by protein recognition using functionalized gold nanoparticles. Nanomed Nanotechnol Biol Med 3:306–310

    Article  CAS  Google Scholar 

  • Blonder R, Katz E, Cohen Y, Itzhak N, Riklin A, Willner I (1996) Application of redox enzymes for probing the antigen-antibody association at monolayer interfaces: development of amperometric immunosensor electrodes. Anal Chem 68:3151–3157

    Article  CAS  Google Scholar 

  • Boujtita M, Chapleau M, El Murr N (1996) Enzymatic electrode for the determination of L-lactate. Electroanalysis 8:485–488

    Article  CAS  Google Scholar 

  • Cano M, Ávila JL, Mayén M, Mena ML, Pingarrón J, Rodríguez-Amaro R (2008) A new, third generation, PVC/TTF–TCNQ composite amperometric biosensor for glucose determination. J Electroanal Chem 615:69–74

    Article  CAS  Google Scholar 

  • Carralero V, González-Cortés A, Yáñez-Sedeño P, Pingarrón JM (2007) Nanostructured progesterone immunosensor using a tyrosinase-colloidal gold-graphite-Teflon biosensor as amperometric transducer. Anal Chim Acta 596:86–91

    Article  CAS  Google Scholar 

  • Chai R, Yuan R, Chai Y, Ou C, Cao S, Li X (2008) Amperometric immunosensors based on layer-by-layer assembly of gold nanoparticles and methylene blue on thiourea modified glassy carbon electrode for determination of human chorionic gonadotrophin. Talanta 74:1330–1336

    Article  CAS  Google Scholar 

  • Chai Y, Tian D, Gu J, Cui H (2011) A novel electrochemiluminescence aptasensor for protein based on a sensitive N-(aminobutyl)-N-ethylisoluminol-functionalized gold nanoprobe. Analyst 136:3244–3251

    Article  CAS  Google Scholar 

  • Chaubey A, Malhotra BD (2002) Mediated biosensors. Biosens Bioelectron 17:441–456

    Google Scholar 

  • Chen Z, Kaplan DL, Gao H, Kumar J, Marx KA, Tripathy SK (1996) Molecular assembly of multilayer enzyme: toward the development of chemiluminescence fiber optic biosensor. Mater Sci Eng, C 4:155–159

    Article  CAS  Google Scholar 

  • Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang XR, Zhang GY, Li XL, Liu Z, Utz PJ, Jiang KL, Fan SS, Dai HJ (2008) Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat Biotechnol 26:1285–1292

    Article  CAS  Google Scholar 

  • Choo YY, Geik YA, Chan YY (2013) Multiplex electrochemical genosensor for identifying toxigenic Vibrio cholerae serogroups O1 and O139. Chem Commun 49:2019–2021

    Article  CAS  Google Scholar 

  • Cooper MA, Singleton VT (2007) A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applicationsof acoustic physics to the analysis of biomolecularinteractions. J Mol Recognit 20:154–184

    Article  CAS  Google Scholar 

  • Cowell DC, Dowman AA, Newman JD, Pirzad R, Rantle C (1992) The polycrystalline fluoride ion-selective electrode and horseradish peroxidase—an alternative electrochemical biosensor? Biosens Bioelectron 7:27–38

    Article  CAS  Google Scholar 

  • Cullen DC, Sethi RS, Lowe CR (1990) Multi-analyte miniature conductance biosensor. Anal Chim Acta 231:33–40

    Article  CAS  Google Scholar 

  • Danielsson B, Mattiasson B (1996) Thermistor-based biosensors. In: Taylor RF (ed) Handbook of chemical and biochemical sensors (Schultz JS. IOP Publishing Ltd, UK

    Google Scholar 

  • Dante S, Duval D, González-Guerrero AB, Sendra JR, Lechuga LM (2012) All-optical phase modulation for integrated interferometric biosensors. Opt Express 20:7195–7205

    Article  CAS  Google Scholar 

  • Das J, Aziz MA, Yang H (2006) A nanocatalyst-based assay for proteins: DNA-free ultrasensitive electrochemical detection using catalytic reduction of p-nitrophenol by gold-nanoparticle labels. J Am Chem Soc 128:16022–16023

    Article  CAS  Google Scholar 

  • de Ávila E-B B, Escamilla-Gómez V, Campuzano S, Pedrero M, M. Pingarrón J (2013) Disposable electrochemical magnetoimmunosensor for the determination of troponin T cardiac marker. Electroanalysis 25:51–58

    Article  CAS  Google Scholar 

  • Dias ACMS, Gomes-Filho SLR, Silva MMS, Dutra RF (2013) A sensor tip based on carbon nanotube-ink printed electrode for the dengue virus NS1 protein. Biosens Bioelectron 44:216–221

    Article  CAS  Google Scholar 

  • Díaz NA, Peinado RMC (1997) Sol-gel cholinesterase biosensor for organophosphorus pesticide fluorimetric analysis. Sens Actuators B38–39:426–431

    Google Scholar 

  • Ding C, Ge Y, Zhang S (2010) Electrochemical and electrochemiluminescence determination of cancer cells based on aptamers and magnetic beads. Chem Eur J 16:10707–10714

    Article  CAS  Google Scholar 

  • Dontsova EA, Zeifman YS, Budashov IA, Eremenko AV, Kalnov SV, Kurochkin IN (2011) Screen-printed carbon electrode for choline based on MnO2 nanoparticles and choline oxidase/polyelectrolyte layers. Sens Actuators B 159:261–270

    Google Scholar 

  • Drummond TG, Hill MG, Barton JK (2003) Electrochemical DNA sensors. Nat Biotechnol 21:1192–1199

    Article  CAS  Google Scholar 

  • Erdem A, Kerman K, Meric B, Ozsoz M (2001) Methylene blue as a novel electrochemical hybridization indicator. Electroanalysis 13:219–223

    Article  CAS  Google Scholar 

  • Fan X, White IM, Shopova SI, Zhu H, Suter JD, Sun Y (2008) Sensitive optical biosensors for unlabeled targets: a review. Anal Chim Acta 620:8–26

    Article  CAS  Google Scholar 

  • Fang L, Lü Z, Wei H, Wang E (2008) A electrochemiluminescence aptasensor for detection of thrombin incorporating the capture aptamer labeled with gold nanoparticles immobilized onto the thio-silanized ITO electrode. Anal Chim Acta 628:80–86

    Article  CAS  Google Scholar 

  • Ferapontova EE, Grigorenko VG, Egorov AM, Börchers T, Ruzgas T, Gorton L (2001) Mediatorless biosensor for H2O2 based on recombinant forms of horseradish peroxidase directly adsorbed on polycristalline gold. Biosens Bioelectron 16:147–157

    Article  CAS  Google Scholar 

  • Fritz J (2008) Cantilever biosensors. Analyst 133:855–863

    Article  CAS  Google Scholar 

  • Fritz J, Baller MK, Lang HP, Rothuizen H, Vettiger P, Meyer E, Güntherodt H-J, Gerber Ch, Gimzewski JK (2000) Translating biomolecular recognition into nanomechanics. Science 288:316–318

    Article  CAS  Google Scholar 

  • Gao M, Qi H, Gao Q, Zhang C (2008) Electrochemical detection of DNA hybridization based on the probe labeled with carbon-nanotubes loaded with silver nanoparticles. Electroanalysis 20:123–130

    Article  CAS  Google Scholar 

  • García-Campaña, AM, Baeyens WRG (eds) (2001) Chemiluminescence in Analytical Chemsitry. Marcel Dekker, Switzerland

    Google Scholar 

  • Giannetto M, Mori L, Mori G, Careri M, Mangia M (2011) New amperometric immunosensor with response enhanced by PAMAM-dendrimers linked via self-assembled monolayers for determination of alpha-fetoprotein in human serum. Sens Actuators, B 159:185–192

    Article  CAS  Google Scholar 

  • Grennan K, Strachan G, Porter AJ, Killard AJ, Smyth MR (2003) Atrazine analysis using an amperometric immunosensor based on single-chain antibody fragments and regeneration-free multi-calibrant measurement. Anal Chim Acta 500:287–298

    Article  CAS  Google Scholar 

  • Gründler P (2007) Chemical sensors. An introductionfor scientists and engineers. Springer, Berlin

    Google Scholar 

  • Guana J-G, Miao Y-Q, Chen J-R (2004) Prussian blue modified amperometric FIA biosensor: one-step immunoassay for α-fetoprotein. Biosens Bioelectron 19:789–794

    Article  CAS  Google Scholar 

  • Gupta A, Akin D, Bashir R (2004) Detection of bacterial cells and antibodies using surface micromachined thin silicon cantilever resonators. J Vac Sci Technol, B 22:2785–2791

    Article  CAS  Google Scholar 

  • Gursahani S, Schoephoerster RT, Prabhakaran M (2008) Exploring electron transfer between heme proteins of cytochrome C super family in biosensors: a molecular mechanics study. J Biomol Struct Dyn 26:329–338

    Article  CAS  Google Scholar 

  • Hoa XD, Kirk AG, Tabrizian M (2007) Towards integrated and sensitive surface plasmon resonance biosensors: a review of recent progress. Biosens Bioelectron 23:151–160

    Article  CAS  Google Scholar 

  • Homola J, Yee SS, Gauglitz G (1999) Surface plasmon resonance sensors: review. Sens Actuators, B 54:3–15

    Article  CAS  Google Scholar 

  • Honda N, Inaba M, Katagiri T, Shoji S, Sato H, Homma T, Osaka T, Saito M, Mizuno J, Wada y (2005) High efficiency electrochemical immuno sensors using 3D comb electrodes. Biosens Bioelectron 20:2306–2309

    Article  CAS  Google Scholar 

  • Hong C, Yuan R, Chai Y, Zhuo Y (2009) Ferrocenyl-doped silica nanoparticles as an immobilized affinity support for electrochemical immunoassay of cancer antigen 15-3. Anal Chim Acta 633:244–249

    Article  CAS  Google Scholar 

  • Huh YS, Chung AJ, Cordovez B, Erickson D (2009) Enhanced on-chip SERS based biomolecular detection using electrokinetically active microwells. Lab Chip 9:433–439

    Article  CAS  Google Scholar 

  • Huska D, Adam V, Babul P, Hrabeta J, Stiborova M, Eckschlager T, Trnkova L, Kizek R (2009) Square-wave voltammetry as a tool for investigation of doxorubicin interactions with DNA isolated from neuroblastoma vells. Electroanalysis 21:487–494

    Article  CAS  Google Scholar 

  • Hwang KS, Lee JH, Park J, Yoon DS, Park JH, Kim TS (2004) In-situ quantitative analysis of a prostatespecific antigen (PSA) using a nanomechanical PZT cantilever. Lab Chip 4:547–552

    Article  CAS  Google Scholar 

  • Hwang KS, Eom K, Lee JH, Chun DW, Cha BH, Dae SY, Kim TS, Park JH (2006) Dominant surface stress driven by biomolecular interactions in the dynamical response of nanomechanical microcantilevers. Appl Phys Lett 89:173905

    Article  CAS  Google Scholar 

  • Hwang KS, Lee S-M, Kim SK, Lee JH, Kim TS (2009) Micro- and nanocantilever devices and systems for biomolecule detection. Ann Rev Anal Chem 2:77–98

    Article  CAS  Google Scholar 

  • Ilic B, Czaplewski D, Zalalutdinov M, Craighead HG, Neuzil P, Campagnolo C, Batt C (2001) Single cell detection with micromechanical oscillators. J Vac Sci Technol, B 19:2825–2828

    Article  CAS  Google Scholar 

  • Inzelt G (2008) Conducting polymers. A new era in electrochemistry. Springer, Berlin

    Google Scholar 

  • Ionescu RE, Gondran C, Bouffier L, Jaffrezic-Renault N, Martelet C, Cosnier S (2010) Label-free impedimetric immunosensor for sensitive detection of atrazine. Electrochim Acta 55:6228–6232

    Article  CAS  Google Scholar 

  • Ivanov A, Evtugyn G, Budnikov H, Girotti S, Ghini S, Ferri E, Montoya A, Mercader JV (2008) Amperometric immunoassay of Azinphos-methyl in water and honeybees based on indirect competitive ELISA. Anal Lett 41:392–405

    Article  CAS  Google Scholar 

  • Janata J (2009) Principles of chemical sensors. Springer, Berlin

    Book  Google Scholar 

  • Kano K, Ikeda T (2000) Fundamentals and practices of mediated bioelectrocatalysis. Anal Sci 16:1013–1021

    Article  CAS  Google Scholar 

  • Karousos NG, Aouabdi S, Way AS, Reddy SM (2002) Quartz crystal microbalance determination of organophosphorusand carbamate pesticides. Anal Chim Acta 469:189–196

    Article  CAS  Google Scholar 

  • Karyakin AA, Vuki M, Lukachova LV, Karyakina EE, Orlov AV, Karpachova GP, Wang J (1999a) Processible polyaniline as an advanced potentiometric pH transducer. Application to biosensors. Anal Chem 71:2534–2540

    Article  CAS  Google Scholar 

  • Karyakin AA, Karyakina EE, Schuhmann W, Schmidt H-L (1999b) Electropolymerized azines. P.II. In a search of the best electrocatalyst of NADH oxidation. Electroanalysis 11:553–557

    Article  CAS  Google Scholar 

  • Karyakin AA, Puganova EA, Bolshakov IA, Karyakina EE (2007) Electrochemical sensor with record performance characteristics. Angew Chem 119:7822–7824

    Article  Google Scholar 

  • Katrlik J, Pizzariello A, Mastihuba V, Svorc J, Stredansky M, Miertus S (1999) Biosensors for L-malate and L-lactate based on solid binding matrix. Anal Chim Acta 379:193–200

    Article  CAS  Google Scholar 

  • Katz E, Willner I (2003) Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy: routes to impedimetric immunosensors, DNA-sensors, and enzyme biosensors. Electroanalysis 15:913–947

    Article  CAS  Google Scholar 

  • Kneipp J, Kneipp H, Kneipp K (2008) SERS—a single-molecule and nanoscale tool for bioanalytics. Chem Soc Rev 37:1052–1060

    Article  CAS  Google Scholar 

  • Knight AW (2001) Electrogenerated chemiluminescence. In: Garcia-Campana AM, Bayens WRG (eds) Chemiluminescence in analytical chemistry. Marcel Dekker, NY, pp 211–246

    Google Scholar 

  • Kok FN, Bozoglu F, Hasir V (2002) Construction of an acetylcholinesterase-choline oxidase biosensor for aldicarb determination. Biosens Bioelectron 17:531–539

    Article  CAS  Google Scholar 

  • Krysteva MA, Yotova LK (1992) Multienzyme membranes for biosensors. J Chem Technol Biotechnol 54:13–18

    Article  CAS  Google Scholar 

  • Kurzweil P (2009) Metal oxides and ion-exchanging surfaces as pH sensors in liquids: state-of-the-art and outlook. Sensors 9:4955–4985

    Article  CAS  Google Scholar 

  • Kwon SJ, Yang H, Jo K, Kwak J (2008) An electrochemical immunosensor using p-aminophenol redox cycling by NADH on a self-assembled monolayer and ferrocene-modified Au electrode. Analyst 133:1599–1604

    Article  CAS  Google Scholar 

  • Laviron E (1995) The use of polarography and cyclic voltammetry for the study of redox systems with adsorption of the reactants. Heterogeneous vs. surface path. J Electroanal Chem 382:111–127

    Article  Google Scholar 

  • Lavrik NV, Sepaniak MJ, Datskos PG (2004) Cantilever transducers as a platform for chemical and biological sensors. Rev Sci Instr 75:2229–2253

    Article  CAS  Google Scholar 

  • Lee TM-H, Hsing I-M (2006) DNA-based bioanalytical microsystems for handheld device applications. Anal Chim Acta 556:26–37

    Article  CAS  Google Scholar 

  • Lee Y, Lim G, Moon W (2007) A piezoelectric micro-cantilever bio-sensor using the mass-micro-balancing technique with self-excitation. J Microsystem Technol 13:563–567

    Article  CAS  Google Scholar 

  • Li D, Yan Y, Wieckowska A, Willner I (2007) Amplified electrochemical detection of DNA through the aggregation of Au nanoparticles on electrodes and the incorporation of methylene blue into the DNA-crosslinked structure. Chem Commun 3544–3546

    Google Scholar 

  • Li T, Guo LP, Wang Z (2008) Gold nanoparticle-based surface enhanced Raman scattering spectroscopic assay for the detection of protein–protein interactions. Anal Sci 24:907–910

    Article  Google Scholar 

  • Liao W-C, Ho JA (2009) Attomole DNA electrochemical sensor for the detection of Escherichia coli O157. Anal Chem 81:2470–2476

    Article  CAS  Google Scholar 

  • Lin Z, Li X, Kraatz H-B (2011) Impedimetric immobilized DNA-based sensor for simultaneous detection of Pb2+, Ag+, and Hg2+. Anal Chem 83:6896–6901

    Article  CAS  Google Scholar 

  • Lippincott-Schwartz J, Patterson GH (2003) Development and use of fluorescent protein markers in living cells. Science 300:87–91

    Article  CAS  Google Scholar 

  • Liu G, Lin Y (2007) Nanomaterial labels in electrochemical immunosensors and immunoassays. Talanta 74:308–317

    Article  CAS  Google Scholar 

  • Liu B, Yan F, Kong J, Deng J (1999) A reagentless amperometric biosensor based on the coimmobilisation of horseradish peroxidase and methylene green in a modified zeolite matrix. Anal Chim Acta 386:31–39

    Article  CAS  Google Scholar 

  • Liu G-D, Yan J-T, Shen G-L, Yu R-Q (2001) Renewable amperometric immunosensor for complement 3 (C3) assay in human serum. Sens Actuators, B 80:95–100

    Article  CAS  Google Scholar 

  • Liu S, Shen Q, Cao Y, Gan L, Wang Z, Steigerwald ML, Guo X (2010) Chemical functionalization of single-walled carbon nanotube field-effect transistors as switches and sensors. Coordinat Chem Rev 254:1101–1116

    Article  CAS  Google Scholar 

  • Loaiza ÓA, Campuzano S (2008) Disposable magnetic DNA sensors for the determination at the attomolar level of a specific enterobacteriaceae family gene. Anal Chem 80:8239–8245

    Article  CAS  Google Scholar 

  • Lu M, Kharkwal S, Ng HY, Li SFY (2011) Carbon nanotube supported MnO2 catalysts for oxygen reduction reaction and their applications in microbial fuel cells. Biosens Bioelectron 26:4728–4732

    Google Scholar 

  • Marazuela MD, Moreno-Bondi MC (2002) Fiber-optic biosensors—an overview. Anal Bioanal Chem 372:664–682

    Article  CAS  Google Scholar 

  • Martínez-Paredes G, González-García MB, Costa-García A (2010) Genosensor for detection of four pneumoniae bacteria using gold nanostructured screen-printed carbon electrodes as transducers. Sens Actuators, B 149:329–335

    Article  CAS  Google Scholar 

  • Marx KM (2003) Quartz crystal microbalance: a useful tool for studying thin polymer films and complex biomolecular systems at the solution-surface interface. Biomacromolecules 4:1099–1120

    Article  CAS  Google Scholar 

  • Milligan C, Ghindilis A (2002) Laccase based sandwich scheme immunosensor employing mediatorless electrocatalysis. Electroanalysis 14:415–419

    Article  CAS  Google Scholar 

  • Mukhopadhyay R, Sumbayev VV, Lorentzen M, Kjems J, Andreasen PA, Besenbacher F (2005) Cantilever sensor for nanomechanical detection of specific protein conformations. Nano Lett 5:2385–2388

    Article  CAS  Google Scholar 

  • Nasef H, Ozalp VC, Beni V, O’Sullivan CK (2010) Melting temperature of surface-tethered DNA. Anal Biochem 406(2010):34–40

    Article  CAS  Google Scholar 

  • Neufeld T, Eshkenazi I, Cohen E, Rishpon J (2000) A micro flow injection electrochemical biosensor for organophosphorous pesticides. Biosen Bioelectron 15:323–329

    Article  CAS  Google Scholar 

  • Neves MMPS, González-García MB, Santos-Silva A, Costa-García A (2012) Voltammetric immunosensor for the diagnosis of celiac disease based on the quantification of anti-gliadin antibodies. Sens Actuators B 163:253–259

    Google Scholar 

  • Nguyen BTT, Ang JQ, Toh C-S (2009) Sensitive detection of potassium ion using Prussian blue nanotube sensor. Electrochem Commun 11:1861–1864

    Article  CAS  Google Scholar 

  • Ojani R, Raoof J-B, Fathi S (2009) Ferricyanide immobilized within organically modified MCM-41; application for electrocatalytic reduction of hydrogen peroxide. J Solid-State Electrochem 13:837–842

    Article  CAS  Google Scholar 

  • Orazem ME, Tribolett B (2008) Electrochemical impedance spectroscopy. Wiley, New York

    Google Scholar 

  • Ovádeková R, Labuda J (2007) DNA binding interactions, structural damage and protection investigated by electrochemical DNA sensors. In: Kizek R (ed) Utilizing of bioelectrochemical and mathematical methods in biological research (Adam V. Research Signpost, Kerala, pp 173–201

    Google Scholar 

  • Palecek E (2002) Past, present and future of nucleic acids electrochemistry. Talanta 56:809–819

    Article  CAS  Google Scholar 

  • Pedersen HC, Jakobsen ML, Hanson SG, Dam-Hansen C, Olesen T, Hansen P (2010) Cantilever biosensor reader using a common-path, holographic optical interferometer. Appl Phys Lett 97:221110

    Article  CAS  Google Scholar 

  • Petryayeva E, Krull UJ (2011) Localized surface plasmon resonance: nanostructures, bioassays and biosensing—A review. Anal Chim Acta 706:8–24

    Article  CAS  Google Scholar 

  • Porfireva AV, Evtugyn GA, Ivanov AN, Hianik T (2010) Impedimetric aptasensors based on carbon nanotubes—poly(methylene blue) composite. Electroanalysis 22:2187–2195

    Article  CAS  Google Scholar 

  • Prieto-Simón B, Macanás J, Muñoz M, Fàbregas E (2007) Evaluation of different mediator-modified screen-printed electrodes used in a flow system as amperometric sensors for NADH. Talanta 71:2102–2107

    Article  CAS  Google Scholar 

  • Prodromidis MI (2010) Impedimetric immunosensors—a review. Electrochim Acta 55:4227–4233

    Article  CAS  Google Scholar 

  • Qu F, Lu H, Yang M, Deng C (2011) Electrochemical immunosensor based on electron transfer mediated by graphene oxide initiated silver enhancement. Biosens Bioelectron 26:4810–4814

    Article  CAS  Google Scholar 

  • Radi A-E, Muñoz-Berbel X, Lates V, Marty J-L (2009) Label-free impedimetric immunosensor for sensitive detection of ochratoxin A. Biosens Bioelectron 24:1888–1892

    Article  CAS  Google Scholar 

  • Rahman MA, Son JI, Won M-S, Shim Y-B (2009) Gold nanoparticles doped conducting polymer nanorod electrodes: ferrocene catalyzed aptamer-based thrombin immunosensor. Anal Chem 81:6604–6611

    Article  CAS  Google Scholar 

  • Raiteri R, Grattarola M, Butt H-J, Skladal P (2001) Micromechanical cantilever-based biosensors. Sens Actuators B 79:115–126

    Article  CAS  Google Scholar 

  • Ramanathan K, Danielsson B (2001) Principles and applications of thermal biosensors. Biosens Bioelectron 16:417–423

    Article  CAS  Google Scholar 

  • Ramanathan K, Khayyami M, Danielsson B (1998) Enzyme biosensors based on thermal transducer/thermistor. In: Enzyme and microbial biosensors: techniques and protocols. Springer 6:175–186

    CAS  Google Scholar 

  • Rawle RJ, Johal MS, Selassie CR (2008) A real-time QCM-D approach to monitoring mammalian DNA damage using DNA adsorbed to a polyelectrolyte surface. Biomacromolecules 9:9–12

    Article  CAS  Google Scholar 

  • Ricci F, Plaxco KW (2008) E-DNA sensors for convenient, label-free electrochemical detection of hybridization. Microchim Acta 163:149–155

    Article  CAS  Google Scholar 

  • Rich RL, Myszka DG (2002) Survey of the year 2001 commercial optical biosensor literature. J Mol Recognit 15:1–25

    Article  CAS  Google Scholar 

  • Rickert J, Göpel W, Beck W, Jung G, Heiduschka P (1996) A ‘mixed’ self-assembled monolayer for an impedimetric immunosensor. Biosens Bioelectron 11:757–768

    Article  CAS  Google Scholar 

  • Roda A, Guardigli M, Michelini E, Mirasoli M (2009) Bioluminescence in analytical chemistry and in vivo imaging.Trends in. Anal Chem 28:307–322

    CAS  Google Scholar 

  • Rosales-Rivera LC, Acero-Sánchez JL, Lozano-Sánchez P, Katakis I, O’Sullivan CK (2012) Amperometric immunosensor for the determination of IgA deficiency in human serum samples. Biosens Bioelectron 33:134–138

    Article  CAS  Google Scholar 

  • Ruan C, Li Y (2001) Detection of zeptomolar concentrations of alkaline phosphatase based on tyrosinase and horse-radish peroxidase bienzyme biosensor. Talanta 54:1095–1103

    Article  CAS  Google Scholar 

  • Ruan C, Yang L, Li Y (2002) Immunobiosensor chips for detection of Escherichia coli O157:H7 using electrochemical impedance spectroscopy. Anal Chem 74:4814–4820

    Article  CAS  Google Scholar 

  • Sadeghi SJ, Ferrero S, Di Nardo G, Gilardi G (2012) Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. Bioelectrochem 86:87–91

    Article  CAS  Google Scholar 

  • Sandifer JR, Voychek JJ (1999) A review of biosensor and industrial applications of pH-ISFETs and evaluation of Honeywell’s “DuraFET”. Microchim Acta 131:91–98

    Article  CAS  Google Scholar 

  • Sato N, Okuma H (2008) Development of single-wall carbon nanotubes modified screen-printed electrode using a ferrocene-modified cationic surfactant for amperometric glucose biosensor applications. Sens Actuators, B 129:188–194

    Article  CAS  Google Scholar 

  • Scheller FW, Schubert F, Neumann B, Pfeiffer D, Hintsche R, Dransfeld I, Wollenberger U, Renneberg R, Warsinke A, Johansson J, Skoog M, Yang X, Bogdanovskaya V, Bückmann A, Zaitsev SYu (1991) Second generation biosensors. Biosens Bioelectron 6:245–253

    Article  CAS  Google Scholar 

  • Shervedani RK, Pourbeyram S (2011) A modification free hybridization biosensor for detection of DNA sequence based on Zr(IV) ion glue mediated the adsorption on Au-MPA SAM electrode. Sens Actuators, B 160:145–153

    Article  CAS  Google Scholar 

  • Skládal P (1997) Advances in electrochemical immunosensors. Electroanalysis 10:737–745

    Article  Google Scholar 

  • Skládal P (2003) Piezoelectric quartz crystal sensors applied for bioanalytical assays and characterization of affinity interactions. J Braz Chem Soc 14:491–502

    Article  Google Scholar 

  • Snevajsova P, Tison L, Brozkova I, Vytrasova J, Metelka R, Vytras K (2010) Carbon paste electrode for voltammetric detection of a specific DNA sequence from potentially aflatoxigenic Aspergillus species. Electrochem Commun 12:106–109

    Article  CAS  Google Scholar 

  • Sun Q, Zhang X (2012) Electrochemiluminescence DNA sensor based on Ru(bpy)3 2+ -doped silica nanoparticle labeling and proximity-dependent surface hybridization assay. J Solid State Electrochem 16:247–252

    Article  CAS  Google Scholar 

  • Sun Z, Ma Z, Zhang W, Wang X, Fan C, Li G (2004) Electrochemical investigations of baicalin and DNA-baicalin interactions. Anal Bioanal Chem 379:283–286

    Article  CAS  Google Scholar 

  • Suprun E, Evtugyn G, Budnikov H, Ricci F, Moscone D, Palleschi G (2005) Acetylcholinesterase sensor based on screen-printed carbon electrode modified with Prussian Blue. Anal Bioanal Chem 383:597–604

    Article  CAS  Google Scholar 

  • Susmel S, Guilbault GG, O’Sullivan CK (2003) Demonstration of labeless detection of food pathogens using electrochemical redox probe and screen printed gold electrodes. Biosens Bioelectron 18:881–889

    Article  CAS  Google Scholar 

  • Tachiya M (1993) Generalization of the Marcus equation for the electron transfer rate. J Phys Chem 97:5911–5916

    Article  CAS  Google Scholar 

  • Takenaka S, Yamashita K, Takagi M, Uto Y, Kondo H (2000) DNA sensing on a DNA probe-modified electrode using ferrocenylnaphthalene diimide as the electrochemically active ligand. Anal Chem 72:1334–1341

    Article  CAS  Google Scholar 

  • Tang D, Yuan R, Chai Y (2006) Electrochemical immuno-bioanalysis for carcinoma antigen 125 based on thionine and gold nanoparticles-modified carbon paste interface. Anal Chim Acta 564:158–165

    Article  CAS  Google Scholar 

  • Taylor RW, Lee TC, Scherman OA, Esteban R, Aizpurua J, Huang FM, Baumberg JJ, Mahajan S (2011) Precise subnanometer plasmonic junctions for SERS within gold nanoparticle assemblies using cucurbit[n]uril “Glue”. ACS Nano 5:3878–3887

    Article  CAS  Google Scholar 

  • van der Schoot BH, Bergveld P (1987/88) ISFET based enzyme sensors. Biosensors 3:161–186

    Google Scholar 

  • Varma S, Yigzaw Y, Gorton L (2006) Prussian blue-glutamate oxidase modified glassy carbon electrode: a sensitive L-glutamate and β-N-oxalyl-α, β-diaminopropionic acid (β-ODAP) sensor. Anal Chim Acta 556:319–325

    Article  CAS  Google Scholar 

  • Vatsyayan P, Chakraborty M, Bordoloi S, Goswami P (2011) Electrochemical investigations of fungal cytochrome P450. J Electroanal Chem 662:312–316

    Article  CAS  Google Scholar 

  • Vig A, Radoi A, Muñoz-Berbel X, Gyemant G, Marty J-L (2009) Impedimetric aflatoxin M1 immunosensor based on colloidal gold and silver electrodeposition. Sens Actuators B 138:214–220

    Google Scholar 

  • Wallace GG, Spinks GM, Kane-Maguire LAP, Teasdale PR (2009) Conductive electroactive polymers. Intelligent polymer systems. CRC Press, Boca Raton

    Google Scholar 

  • Wang J (2006) Analytical electrochemistry. Wiley-VCH, 2006

    Google Scholar 

  • Wang X, Zhou J, Yun W, Xiao S, Chang Z, He P, Fang Y (2007) Detection of thrombin using electrogenerated chemiluminescence based on Ru(bpy)3 2+ -doped silica nanoparticle aptasensor via target protein-induced strand displacement. Anal Chim Acta 598:242–248

    Article  CAS  Google Scholar 

  • Wang Q, Shi J, Ni J, Gao F, Gao F, Weng W, Jiao K (2011) DNA hybridization biosensor using chitosan-carbon nanotubes composite film as an immobilization platform and [Cu(bpy)(MBZ)2(H2O)] (bpy = 2,2′-bipyridine, MBZ = p-methylbenzoate) as a novel redox indicator. Electrochim Acta 56:3829–3834

    Article  CAS  Google Scholar 

  • Warsinke A, Benkert A, Scheller FW (2000) Electrochemical immunoassays. Fresenius J Anal Chem 366:622–634

    Article  CAS  Google Scholar 

  • Willner I, Willner B (2001) Biomaterials integrated with electronic elements: en route to bioelectronics. Trends in Biotechnol 19:222–230

    Article  CAS  Google Scholar 

  • Wu GH, Datar RH, Hansen KM, Thundat T, Cote RJ, Majumdar A (2001) Bioassay of prostate-specific antigen (PSA) using microcantilevers. Nat Biotechnol 19:856–860

    Article  CAS  Google Scholar 

  • Xie B, Ramanathan K, Danielsson B (1999) Principles of enzyme thermistor systems: application tobiomedical and other measurements. In: Advances in biochemical engineering biotechnology. Springer 64:1–34

    CAS  Google Scholar 

  • Xuejiang W, Dzyadevych SV, Chovelon JM, Renault NJ, Ling C, Siqing X, Jianfu Z (2006) Conductometric nitrate biosensor based on methyl viologen/Nafion/nitrate reductase interdigitated electrodes. Talanta 69:450–455

    Article  CAS  Google Scholar 

  • Yabuki S, Mizutani F (2004) Electrochemical measurement of phenothiazine-interacted DNA. Bioelectrochem 63:253–255

    Google Scholar 

  • Yakovleva M, Bhand S, Danielsson B (2013) The enzyme thermistor—A realistic biosensor concept. A critical review. Anal Chim Acta 766:1–12

    Article  CAS  Google Scholar 

  • Yang T-H, Hung C-L, Ke J-H, Zen J-M (2008) An electrochemically preanodized screen-printed carbon electrode for achieving direct electron transfer to glucose oxidase. Electrochem Commun 10:1094–1097

    Article  CAS  Google Scholar 

  • Yaropolov AI, Skorobogat’ko OV, Vartanov SS, Varfolomeyev SD (1994) Laccase: properties, catalytic mechanism, and applicability. Appl Biochem Buiotechnol 49:257–280

    Article  CAS  Google Scholar 

  • Yashina EI, Borisova AV, Karyakina EE, Shchegolikhina OI, Vagin MYu, Sakharov DA, Tonevitsky AG, Karyakin AA (2010) Sol-gel immobilization of lactate oxidase from organic solvent: toward the advanced lactate biosensor. Anal Chem 82(2010):1601–1604

    Article  CAS  Google Scholar 

  • Zayats M, Willner B, Willner I (2008) Design of amperometric biosensors and biofuel cells by the reconstitution of electrically contacted enzyme electrodes. Electroanalysis 20:583–601

    Article  CAS  Google Scholar 

  • Zhang J, Lang HP, Huber F, Bietsch A, Grange W, Certa U, Mckendry R, Güntherodt H-J, Hegner M, Gerber Ch (2006) Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA. Nat Nanotechnol 1:214–220

    Article  CAS  Google Scholar 

  • Zhang L, Liu Y, Chen T (2009) Label-free amperometric immunosensor based on antibody immobilized on a positively charged gold nanoparticle/-cysteine-modified gold electrode. Microchim Acta 164:161–166

    Article  CAS  Google Scholar 

  • Zhong Z, Fritzsche M, Pieper SB, Wood TK, Lear KL, Dandy DS, Reardon KF (2011) Fiber optic monooxygenase biosensor for toluene concentration measurement in aqueous samples. Biosens Bioelectron 26:2507–2512

    Google Scholar 

  • Zhu N, Gao H, Xu Q, Lin Y, Su L, Mao L (2010) Sensitive impedimetric DNA biosensor with poly(amidoamine) dendrimer covalently attached onto carbon nanotube electronic transducers as the tether for surface confinement of probe DNA. Biosens Bioelectron 25:1498–1503

    Article  CAS  Google Scholar 

  • Zhuo Y, Chai Y-Q, Yuan R, Mao L, Yuan Y-L, Han J (2011) Glucose oxidase and ferrocene labels immobilized at Au/TiO2 nanocomposites with high load amount and activity for sensitive immunoelectrochemical measurement of ProGRP biomarker. Biosens Bioelectron 26:3838–3844

    Article  CAS  Google Scholar 

  • Ziyatdinova G, Galandova J, Labuda J (2008) Impedimetric nanostructured disposable DNA-based biosensors for the detection of deep DNA damage and effect of antioxidants. Int J Electrochem Sci 3:223–235

    CAS  Google Scholar 

  • Zoski CG (ed) (2007) Handbook of electrochemistry. Elsevier, Amsterdam

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Analytical Chemistry, Kazan Federal University, Kremlevskaya Street 18, Kazan, Russia, 420008

    Gennady Evtugyn

Authors
  1. Gennady Evtugyn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gennady Evtugyn .

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Evtugyn, G. (2014). Biosensor Signal Transducers. In: Biosensors: Essentials. Lecture Notes in Chemistry, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40241-8_3

Download citation

Publish with us

Policies and ethics

Search

Navigation