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Targeted Intraoperative Radiotherapy and Persistent Pain After Treatment

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Targeted Intraoperative Radiotherapy in Oncology

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Abstract

Persistent pain has been established to be a significant problem following various surgical procedures (Kehlet et al. 2006; Aasvang et al. 2010; Wildgaard et al. 2009), including those used for breast cancer (Andersen and Kehlet 2011). Factors that may modify the risk of developing persistent pain are age, preoperative pain, nerve injury, acute postoperative pain, psychosocial factors, type of surgery, adjuvant treatment, type of analgesia and genetics; these are often divided into pre-, intra- and postoperative risk factors (Kehlet et al. 2006; Andersen and Kehlet 2011). A review of persistent pain following breast cancer treatment (PPBCT) has recently been published (Andersen and Kehlet 2011). This chapter discusses radiotherapy as a risk factor for the development of PPBCT, describes the results of a cross-sectional questionnaire study on PPBCT and examines avenues for further research.

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Acknowledgements

This work was funded by the Danish Cancer Society and the research leading to these results is part of the European Collaboration, which has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no 115007, the resources of which are composed of a financial contribution from the European Union's Seventh Framework Programme (FP7/2007–2013) and an in kind contribution from EFPIA companies.

The authors declare no conflict of interests.

Author information

Authors and Affiliations

  1. Section for Surgical Pathophysiology, 7621, Rigshospitalet, Copenhagen University, Blegdamsvej 9, DK-2100, Copenhagen, Denmark

    Kenneth Geving Andersen MD

  2. Department of Breast Surgery, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

    Kenneth Geving Andersen MD

  3. Department of Breast Surgery, Herlev Hospital, Copenhagen University, Herlev Ringvej 75, DK-2730, Herlev, Denmark

    Henrik Flyger MD, PhD

Authors
  1. Kenneth Geving Andersen MD
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  2. Henrik Flyger MD, PhD
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Correspondence to Kenneth Geving Andersen MD .

Editor information

Editors and Affiliations

  1. Department of Surgery, Royal Free Hospital, London, United Kingdom

    Mohammed Keshtgar

  2. Department of Radiation Oncology, Royal Free Hospital, London, United Kingdom

    Katharine Pigott

  3. University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany

    Frederik Wenz

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Andersen, K.G., Flyger, H. (2014). Targeted Intraoperative Radiotherapy and Persistent Pain After Treatment. In: Keshtgar, M., Pigott, K., Wenz, F. (eds) Targeted Intraoperative Radiotherapy in Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39821-6_11

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  • DOI: https://doi.org/10.1007/978-3-642-39821-6_11

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-39820-9

  • Online ISBN: 978-3-642-39821-6

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