Abstract
Renal involvement in multiple myeloma and other plasma cell dyscrasias is largely the result of the effects of the monoclonal protein, usually the light chain, and may be clinically manifested in multiple ways [1–3]. The major lesions include light-chain (Bence Jones or myeloma) cast nephropathy, monoclonal immunoglobulin deposition disease and amyloidosis, usually AL type. The pathologic features of all are distinct and will be discussed in individual chapters. Although each disorder appears to be the consequence of a distinct property of the monoclonal protein, usually the light chain and therefore affected patients theoretically may develop only one of these lesions (one light-chain disease per patient) in practice two or all three may be identified in renal biopsies.
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Fogo, A.B., Cohen, A.H., Colvin, R.B., Jennette, J.C., Alpers, C.E. (2014). Bence Jones Cast Nephropathy. In: Fundamentals of Renal Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39080-7_16
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DOI: https://doi.org/10.1007/978-3-642-39080-7_16
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