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Protein–Protein Interaction Inhibitors: Case Studies on Small Molecules and Natural Compounds

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Disruption of Protein-Protein Interfaces

Abstract

Many biological functions involve the formation of protein–protein complexes, and the inhibition of this process has garnered significant interest in pharmaceutical research investigating novel therapies for several human diseases. From an evolutionary perspective, proteins have evolved to optimize and differentiate their functions, a process that is mediated by the modulation of the interacting surfaces.

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Abbreviations

Aβ:

β-amyloid

AβPP:

β-amyloid protein precursor

Aib:

α-aminoisobutyric acid

BIR:

Baculoviral inhibitory repeat

c-kit:

Tyrosine kinase receptor

dTMP:

2′-deoxythymidine-5′-monophosphate

dUMP:

2′-deoxyuridine-5′-monophosphate

FRET:

Förster resonance energy transfer

GAPs:

GTPase-activating proteins

GEFs:

Guanine nucleotide exchange factors

HDM2:

Human double minute 2

HeLa:

Human cervical carcinoma cancer cell line

HTS:

High-throughput screening

hTS:

Human thymidylate synthase

IAPs:

Inhibitors of apoptosis proteins

MAP:

Mitogen-activated protein

MDM2:

Mouse double minute 2

NCI:

National Cancer Institute

NSAIDs:

Non-steroidal anti-inflammatory drugs

O-PHDEs:

Oxy-polyhalogenated diphenyl ethers

PAC:

Proteasome assembling chaperone

PBD:

Polo-box domain

PDPA:

1,3-propanediphosphonic acid

PI3K:

Phosphoinositol-3′-kinase

PPIs:

Protein–protein interactions

PS:

Presenilin

SCF:

Stem cell factor

Tcf4:

T-cell factor 4

XIAP:

X-linked Inhibitor of apoptosis protein

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Authors and Affiliations

  1. Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41125, Modena, Italy

    Stefania Ferrari, Federica Pellati & Maria Paola Costi

Authors
  1. Stefania Ferrari
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  2. Federica Pellati
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  3. Maria Paola Costi
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Corresponding author

Correspondence to Maria Paola Costi .

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Editors and Affiliations

  1. , Department of Biotechnology, Chemistry a, University of Siena, Siena, Siena, I-53100, Italy

    Stefano Mangani

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Ferrari, S., Pellati, F., Costi, M.P. (2013). Protein–Protein Interaction Inhibitors: Case Studies on Small Molecules and Natural Compounds. In: Mangani, S. (eds) Disruption of Protein-Protein Interfaces. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37999-4_2

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