Abstract
There are various immunocompetent cells including the so-called macrophages in human nasal mucosa. Those cells are essential for a defense system against various invading pathogens such as bacteria and virus. On the other hand, those cells are also key players in the pathogenesis of rhinosinusitis and allergic rhinitis at the epithelial linings of nasal cavity and paranasal sinuses. Among them, macrophages are well known to have immunologically an important role as a scavenger cell and antigen-presenting cells (APCs), in order to mount innate and acquired immunity in the upper and lower respiratory tract (Kaneda et al., Auris Nasus Larynx 18:331–342, 1991;Yamada et al., Rhinology 43:190–198, 2005). In this chapter, general concept of macrophage lineage cells and its function are introduced, and the exact role of those cells in the pathogenesis of rhinosinusitis and allergic rhinitis can be discussed in accordance with previously published data and our unpublished data as well.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aderem A, Underhill DM. Mechanisms of phagocytosis in macrophages. Annu Rev Immunol. 1999;17:593–623.
Albegger KW. Cluster formation in human nasal polyps. A light- and electron-microscopic investigation. ORL J Otorhinolaryngol Relat Spec. 1977;39(2):107–12.
Chen G, Shaw MH, et al. NOD-like receptors: role in innate immunity and inflammatory disease. Ann Rev Pathol. 2009;4:365–98.
Geissmann F, Manz MG, Jung S, et al. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327(5966):656–61.
Hume DA. Macrophages as APC and the dendritic cell myth. J Immunol. 2008;181(9):5829–35.
Ichimiya I, Kawauchi H, Fujiyoshi T, et al. Distribution of immunocompetent cells in normal nasal mucosa: comparisons among germ-free, specific pathogen-free, and conventional mice. Ann Otol Rhinol Laryngol. 1991;100(8):638–42.
Jahnsen FL, Gran E, Haye R, et al. Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. Am J Respir Cell Mol Biol. 2004;30:31–7.
Jutras I, Desjardins M. Phagocytosis: at the crossroads of innate and adaptive immunity. Annu Rev Cell Dev Biol. 2005;21:511–27.
Kaneda N, Kawauchi H, Mogi G. Role of phagocytes in antimicrobial defense of the middle ear. Auris Nasus Larynx. 1991;18:331–42.
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;5:373–84.
Kawauchi H, DeMaria TF, Lim DJ. Endotoxin permeability through the round window. Acta Otolaryngol (Stockh) Suppl. 1998;457:100–15.
Kawauchi H, Aoi N, Murata A, et al. Clinical application of mucosal immune system for down-rugulating nasal allergy. Arerugi. 2009;58(2):103–11.
Kawauchi H, Goda K, Tongu M, et al. Short review on sublingual immunotherapy for patients with allergic rhinitis: from bench to bedside. Adv Otorhinolaryngol. 2011;72:103–6.
Krysko O, Holtappels G, Zhang G, et al. Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells. Allergy. 2011;66(3):396–403.
Lipscomb MF, Masten BJ. Dendritic cells: immune regulators in health and disease. Physiol Rev. 2002;82:97–130.
Mizuno S, Kanai T, Mikami Y, et al. CCR9(+) plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice. Immunol Lett. 2012;146(1–2):64–9.
Nakano H, Gunn MD. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J Immunol. 2001;166:361–9.
Sallusto F, Baggiolini M. Chemokines and leukocyte traffic. Nat Immunol. 2008;9(9):949–52.
Schroder K, Hertzog PJ, Ravasi T, Schroder K, Hertzog PJ, Ravasi T, et al. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004;75:163–89.
Stanley ER. Lineage commitment: cytokines instruct, at last! Cell Stem Cell. 2009;5(3):234–6.
Takamura K, Fukuyama S, Nagatake T, et al. Regulatory role of CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007;179(9):5897–906.
Taylor PR, Martinez-Pomares L, Stacey M, et al. Macrophage receptors and immune recognition. Annu Rev Immunol. 2005;23:901–44.
Yamada T, Kataoka S, Ogasawara K, et al. Mucosal immunity of nasopharynx: an experimental study in TCR-transgenic (OVA23-3)mice. Rhinology. 2005;43:190–8.
Yamada T, Tongu M, Goda K, et al. Sublingual immunotherapy induces regulatory function of IL-10-expressing CD4+CD25+Foxp3+ T cells of cervical lymph nodes in murine allergic rhinitis model. J Allergy. 2012;2012:490905.
Yogev N, Frommer F, Lukas D, et al. Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells. Immunity. 2012;37(2):264–75.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kawauchi, H. (2013). Macrophage. In: Önerci, T. (eds) Nasal Physiology and Pathophysiology of Nasal Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37250-6_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-37250-6_6
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-37249-0
Online ISBN: 978-3-642-37250-6
eBook Packages: MedicineMedicine (R0)