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Disability and Overall Burden Related with Bipolar Disorder

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Bipolar Disorder

Abstract

The concept of disability is complex and has been revised several times in the past. It is defined as the consequence of an impairment which might be physical, cognitive, mental or sensory and could be either developmental or acquired. Combinations also occur. The consequences of any impairment could be loss of function or limitations in participation in various activities and in completing tasks.

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References

  • Allen MH, Chessick CA, Miklowitz DJ, Goldberg JF, Wisniewski SR, Miyahara S, Calabrese JR, Marangell L, Bauer MS, Thomas MR, Bowden CL, Sachs GS (2005) Contributors to suicidal ideation among bipolar patients with and without a history of suicide attempts. Suicide Life Threat Behav 35(6):671–680

    PubMed  Google Scholar 

  • Altshuler LL, Gitlin MJ, Mintz J, Leight KL, Frye MA (2002) Subsyndromal depression is associated with functional impairment in patients with bipolar disorder. J Clin Psychiatry 63(9):807–811

    PubMed  Google Scholar 

  • Altshuler LL, Bearden CE, Green MF, van Gorp W, Mintz J (2008) A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study. Psychiatry Res 157(1–3):289–293. doi:10.1016/j.psychres.2007.01.001, S0165-1781(07)00003-0 [pii]

    PubMed  Google Scholar 

  • Amore M, Menchetti M, Tonti C, Scarlatti F, Lundgren E, Esposito W, Berardi D (2008) Predictors of violent behavior among acute psychiatric patients: clinical study. Psychiatry Clin Neurosci 62(3):247–255. doi:10.1111/j.1440-1819.2008.01790.x

    PubMed  Google Scholar 

  • Angst J, Angst F, Gerber-Werder R, Gamma A (2005) Suicide in 406 mood-disorder patients with and without long-term medication: a 40 to 44 years’ follow-up. Arch Suicide Res 9(3):279–300

    PubMed  Google Scholar 

  • Atre-Vaidya N, Taylor MA, Seidenberg M, Reed R, Perrine A, Glick-Oberwise F (1998) Cognitive deficits, psychopathology, and psychosocial functioning in bipolar mood disorder. Neuropsychiatry Neuropsychol Behav Neurol 11(3):120–126

    CAS  PubMed  Google Scholar 

  • Bagalman E, Yu-Isenberg KS, Durden E, Crivera C, Dirani R, Bunn WB 3rd (2010) Indirect costs associated with nonadherence to treatment for bipolar disorder. J Occup Environ Med 52(5):478–485. doi:10.1097/JOM.0b013e3181db811d

    PubMed  Google Scholar 

  • Bauer M, Glenn T, Grof P, Rasgon NL, Marsh W, Sagduyu K, Alda M, Lewitzka U, Sasse J, Kozuch-Krolik E, Whybrow PC (2009) Frequency of subsyndromal symptoms and employment status in patients with bipolar disorder. Soc Psychiatry Psychiatr Epidemiol 44(7):515–522. doi:10.1007/s00127-008-0464-4

    PubMed  Google Scholar 

  • Bauer R, Gottfriedsen GU, Binder H, Dobmeier M, Cording C, Hajak G, Spiessl H (2010) Burden of caregivers of patients with bipolar affective disorders. Am J Orthopsychiatry 81(1):139–148. doi:10.1111/j.1939-0025.2010.01081.x

    Google Scholar 

  • Bauer R, Koepke F, Sterzinger L, Spiessl H (2012) Burden, rewards, and coping–the ups and downs of caregivers of people with mental illness. J Nerv Ment Dis 200(11):928–934. doi:10.1097/NMD.0b013e31827189b1

    PubMed  Google Scholar 

  • Bellack AS, Morrison RL, Mueser KT, Wade J (1989) Social competence in schizoaffective disorder, bipolar disorder, and negative and non-negative schizophrenia. Schizophr Res 2(4–5):391–401, 0920-9964(89)90032-7 [pii]

    CAS  PubMed  Google Scholar 

  • Bernhard B, Schaub A, Kummler P, Dittmann S, Severus E, Seemuller F, Born C, Forsthoff A, Licht RW, Grunze H (2006) Impact of cognitive-psychoeducational interventions in bipolar patients and their relatives. Eur Psychiatry 21(2):81–86. doi:10.1016/j.eurpsy.2005.09.007

    PubMed  Google Scholar 

  • Bowden CL, Krishnan AA (2004) Pharmacotherapy for bipolar depression: an economic assessment. Expert Opin Pharmacother 5(5):1101–1107. doi:10.1517/14656566.5.5.1101

    CAS  PubMed  Google Scholar 

  • Bowie CR, Depp C, McGrath JA, Wolyniec P, Mausbach BT, Thornquist MH, Luke J, Patterson TL, Harvey PD, Pulver AE (2010) Prediction of real-world functional disability in chronic mental disorders: a comparison of schizophrenia and bipolar disorder. Am J Psychiatry 167(9):1116–1124. doi:10.1176/appi.ajp.2010.09101406, appi.ajp.2010.09101406 [pii]

    PubMed Central  PubMed  Google Scholar 

  • Brodaty H, Green A (2002) Who cares for the carer? The often forgotten patient. Aust Fam Physician 31(9):833–836

    PubMed  Google Scholar 

  • Brodie HK, Leff MJ (1971) Bipolar depression–a comparative study of patient characteristics. Am J Psychiatry 127(8):1086–1090

    CAS  PubMed  Google Scholar 

  • Brook RA, Rajagopalan K, Kleinman NL, Smeeding JE, Brizee TJ, Gardner HH (2006) Incurring greater health care costs: risk stratification of employees with bipolar disorder. Prim Care Companion J Clin Psychiatry 8(1):17–24

    PubMed Central  PubMed  Google Scholar 

  • Burdick KE, Goldberg JF, Harrow M (2010) Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up. Acta Psychiatr Scand 122(6):499–506. doi:10.1111/j.1600-0447.2010.01590.x, ACP1590 [pii]

    CAS  PubMed Central  PubMed  Google Scholar 

  • Cannon M, Jones P, Gilvarry C, Rifkin L, McKenzie K, Foerster A, Murray RM (1997) Premorbid social functioning in schizophrenia and bipolar disorder: similarities and differences. Am J Psychiatry 154(11):1544–1550

    CAS  PubMed  Google Scholar 

  • Centorrino F, Mark TL, Talamo A, Oh K, Chang J (2009) Health and economic burden of metabolic comorbidity among individuals with bipolar disorder. J Clin Psychopharmacol 29(6):595–600. doi:10.1097/JCP.0b013e3181bef8a6, 00004714-200912000-00014 [pii]

    PubMed  Google Scholar 

  • Chadda RK, Singh TB, Ganguly KK (2007) Caregiver burden and coping: a prospective study of relationship between burden and coping in caregivers of patients with schizophrenia and bipolar affective disorder. Soc Psychiatry Psychiatr Epidemiol 42(11):923–930. doi:10.1007/s00127-007-0242-8

    PubMed  Google Scholar 

  • Chakrabarti S, Gill S (2002) Coping and its correlates among caregivers of patients with bipolar disorder: a preliminary study. Bipolar Disord 4(1):50–60

    PubMed  Google Scholar 

  • Chakrabarti S, Kulhara P, Verma SK (1992) Extent and determinants of burden among families of patients with affective disorders. Acta Psychiatr Scand 86(3):247–252

    CAS  PubMed  Google Scholar 

  • Chand PK, Mattoo SK, Sharan P (2004) Quality of life and its correlates in patients with bipolar disorder stabilized on lithium prophylaxis. Psychiatry Clin Neurosci 58(3):311–318. doi:10.1111/j.1440-1819.2004.01237.xPCN1237

    PubMed  Google Scholar 

  • Chessick CA, Perlick DA, Miklowitz DJ, Kaczynski R, Allen MH, Morris CD, Marangell LB (2007) Current suicide ideation and prior suicide attempts of bipolar patients as influences on caregiver burden. Suicide Life Threat Behav 37(4):482–491. doi:10.1521/suli.2007.37.4.482

    PubMed  Google Scholar 

  • Chessick CA, Perlick DA, Miklowitz DJ, Dickinson LM, Allen MH, Morris CD, Gonzalez JM, Marangell LB, Cosgrove V, Ostacher M (2009) Suicidal ideation and depressive symptoms among bipolar patients as predictors of the health and well-being of caregivers. Bipolar Disord 11(8):876–884. doi:10.1111/j.1399-5618.2009.00765.x

    PubMed Central  PubMed  Google Scholar 

  • Chisholm D, van Ommeren M, Ayuso-Mateos JL, Saxena S (2005) Cost-effectiveness of clinical interventions for reducing the global burden of bipolar disorder. Br J Psychiatry 187:559–567. doi:10.1192/bjp.187.6.559, 187/6/559 [pii]

    PubMed  Google Scholar 

  • Cook JA, Lefley HP, Pickett SA, Cohler BJ (1994) Age and family burden among parents of offspring with severe mental illness. Am J Orthopsychiatry 64(3):435–447

    CAS  PubMed  Google Scholar 

  • Corrigan PW, Wassel A (2008) Understanding and influencing the stigma of mental illness. J Psychosoc Nurs Ment Health Serv 46(1):42–48

    PubMed  Google Scholar 

  • Corring DJ (2002) Quality of life: perspectives of people with mental illnesses and family members. Psychiatr Rehabil J 25(4):350–358

    PubMed  Google Scholar 

  • Coryell W, Turvey C, Endicott J, Leon AC, Mueller T, Solomon D, Keller M (1998) Bipolar I affective disorder: predictors of outcome after 15 years. J Affect Disord 50(2–3):109–116

    CAS  PubMed  Google Scholar 

  • Cuijpers P (1999) The effects of family intervention on relatives’ burden: a meta-analysis. J Ment Health 8:275–285

    Google Scholar 

  • Currier GW, Allen MH (2000) Emergency psychiatry: physical and chemical restraint in the psychiatric emergency service. Psychiatr Serv 51(6):717–719

    CAS  PubMed  Google Scholar 

  • Das Gupta R, Guest JF (2002) Annual cost of bipolar disorder to UK society. Br J Psychiatry 180:227–233

    PubMed  Google Scholar 

  • de Zelicourt M, Dardennes R, Verdoux H, Gandhi G, Khoshnood B, Chomette E, Papatheodorou ML, Edgell ET, Even C, Fagnani F (2003) Frequency of hospitalisations and inpatient care costs of manic episodes: in patients with bipolar I disorder in France. Pharmacoeconomics 21(15):1081–1090, 21152 [pii]

    PubMed  Google Scholar 

  • Dean BB, Gerner D, Gerner RH (2004) A systematic review evaluating health-related quality of life, work impairment, and healthcare costs and utilization in bipolar disorder. Curr Med Res Opin 20(2):139–154. doi:10.1185/030079903125002801

    PubMed  Google Scholar 

  • Depp CA, Davis CE, Mittal D, Patterson TL, Jeste DV (2006) Health-related quality of life and functioning of middle-aged and elderly adults with bipolar disorder. J Clin Psychiatry 67(2):215–221

    PubMed  Google Scholar 

  • Depp CA, Mausbach BT, Eyler LT, Palmer BW, Cain AE, Lebowitz BD, Patterson TL, Jeste DV (2009) Performance-based and subjective measures of functioning in middle-aged and older adults with bipolar disorder. J Nerv Ment Dis 197(7):471–475. doi:10.1097/NMD.0b013e3181ab5c9b, 00005053-200907000-00001 [pii]

    PubMed  Google Scholar 

  • Dickerson FB, Sommerville J, Origoni AE, Ringel NB, Parente F (2001) Outpatients with schizophrenia and bipolar I disorder: do they differ in their cognitive and social functioning? Psychiatry Res 102(1):21–27

    CAS  PubMed  Google Scholar 

  • Dilsaver SC (2010) An estimate of the minimum economic burden of bipolar I and II disorders in the United States: 2009. J Affect Disord 129(1–3):79–83. doi:10.1016/j.jad.2010.08.030, S0165-0327(10)00566-5 [pii]

    Google Scholar 

  • DiNicola VF (1989) The child’s predicament in families with a mood disorder. Research findings and family interventions. Psychiatr Clin North Am 12(4):933–949

    CAS  PubMed  Google Scholar 

  • Dion GL, Tohen M, Anthony WA, Waternaux CS (1988) Symptoms and functioning of patients with bipolar disorder six months after hospitalization. Hosp Community Psychiatry 39(6):652–657

    CAS  PubMed  Google Scholar 

  • Dixon L, Stewart B, Burland J, Delahanty J, Lucksted A, Hoffman M (2001) Pilot study of the effectiveness of the family-to-family education program. Psychiatr Serv 52(7):965–967

    CAS  PubMed  Google Scholar 

  • Dore G, Romans SE (2001) Impact of bipolar affective disorder on family and partners. J Affect Disord 67(1–3):147–158, S0165032701004505 [pii]

    CAS  PubMed  Google Scholar 

  • Eisdorfer C (1991) Caregiving: an emerging risk factor for emotional and physical pathology. Bull Menn Clin 55(2):238–247

    CAS  Google Scholar 

  • Elinson L, Houck P, Pincus HA (2007) Working, receiving disability benefits, and access to mental health care in individuals with bipolar disorder. Bipolar Disord 9(1–2):158–165. doi:10.1111/j.1399-5618.2007.00431.x, BDI431 [pii]

    PubMed  Google Scholar 

  • Fadden G, Bebbington P, Kuipers L (1987) The burden of care: the impact of functional psychiatric illness on the patient’s family. Br J Psychiatry 150:285–292

    CAS  PubMed  Google Scholar 

  • Fajutrao L, Locklear J, Priaulx J, Heyes A (2009) A systematic review of the evidence of the burden of bipolar disorder in Europe. Clin Pract Epidemiol Ment Health 5:3. doi:10.1186/1745-0179-5-3, 1745-0179-5-3 [pii]

    PubMed Central  PubMed  Google Scholar 

  • Ferrier IN, Stanton BR, Kelly TP, Scott J (1999) Neuropsychological function in euthymic patients with bipolar disorder. Br J Psychiatry 175:246–251

    CAS  PubMed  Google Scholar 

  • Fisher LJ, Goldney RD, Dal Grande E, Taylor AW, Hawthorne G (2007) Bipolar disorders in Australia. A population-based study of excess costs. Soc Psychiatry Psychiatr Epidemiol 42(2):105–109. doi:10.1007/s00127-006-0133-4

    PubMed  Google Scholar 

  • Fristad MA (2006) Psychoeducational treatment for school-aged children with bipolar disorder. Dev Psychopathol 18(4):1289–1306. doi:10.1017/S0954579406060627

    PubMed  Google Scholar 

  • Fristad MA, Goldberg-Arnold JS, Gavazzi SM (2003) Multi-family psychoeducation groups in the treatment of children with mood disorders. J Marital Fam Ther 29(4):491–504

    PubMed  Google Scholar 

  • Gallagher SK, Mechanic D (1996) Living with the mentally ill: effects on the health and functioning of other household members. Soc Sci Med 42(12):1691–1701, 0277953695002960 [pii]

    CAS  PubMed  Google Scholar 

  • Gardner HH, Kleinman NL, Brook RA, Rajagopalan K, Brizee TJ, Smeeding JE (2006) The economic impact of bipolar disorder in an employed population from an employer perspective. J Clin Psychiatry 67(8):1209–1218

    PubMed  Google Scholar 

  • Giglio LM, Magalhaes PV, Kapczinski NS, Walz JC, Kapczinski F (2010) Functional impact of biological rhythm disturbance in bipolar disorder. J Psychiatr Res 44(4):220–223. doi:10.1016/j.jpsychires.2009.08.003, S0022-3956(09)00176-9 [pii]

    PubMed  Google Scholar 

  • Gilbert AM, Olino TM, Houck P, Fagiolini A, Kupfer DJ, Frank E (2010) Self-reported cognitive problems predict employment trajectory in patients with bipolar I disorder. J Affect Disord 124(3):324–328. doi:10.1016/j.jad.2009.11.012, S0165-0327(09)00505-9 [pii]

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gitlin MJ, Swendsen J, Heller TL, Hammen C (1995) Relapse and impairment in bipolar disorder. Am J Psychiatry 152(11):1635–1640

    CAS  PubMed  Google Scholar 

  • Glahn DC, Bearden CE, Bowden CL, Soares JC (2006) Reduced educational attainment in bipolar disorder. J Affect Disord 92(2–3):309–312. doi:10.1016/j.jad.2006.01.025, S0165-0327(06)00046-2 [pii]

    PubMed  Google Scholar 

  • Goldberg TE, Gold JM, Greenberg R, Griffin S, Schulz SC, Pickar D, Kleinman JE, Weinberger DR (1993) Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery. Am J Psychiatry 150(9):1355–1362

    CAS  PubMed  Google Scholar 

  • Goldberg JF, Harrow M, Grossman LS (1995) Course and outcome in bipolar affective disorder: a longitudinal follow-up study. Am J Psychiatry 152(3):379–384

    CAS  PubMed  Google Scholar 

  • Goldberg JF, Harrow M, Leon AC (1996) Lithium treatment of bipolar affective disorders under naturalistic followup conditions. Psychopharmacol Bull 32(1):47–54

    CAS  PubMed  Google Scholar 

  • Goldstein TR, Miklowitz DJ, Richards JA (2002) Expressed emotion attitudes and individual psychopathology among the relatives of bipolar patients. Fam Process 41(4):645–657

    PubMed  Google Scholar 

  • Gonzalez JM, Perlick DA, Miklowitz DJ, Kaczynski R, Hernandez M, Rosenheck RA, Culver JL, Ostacher MJ, Bowden CL (2007a) Factors associated with stigma among caregivers of patients with bipolar disorder in the STEP-BD study. Psychiatr Serv 58(1):41–48. doi:10.1176/appi.ps.58.1.41-a, 58/1/41-a [pii]

    PubMed  Google Scholar 

  • Gonzalez JM, Thompson P, Escamilla M, Araga M, Singh V, Farrelly N, Thase ME, Miklowitz DJ, Bowden CL (2007b) Treatment characteristics and illness burden among European Americans, African Americans, and Latinos in the first 2,000 patients of the systematic treatment enhancement program for bipolar disorder. Psychopharmacol Bull 40(1):31–46

    PubMed  Google Scholar 

  • Goodwin FK, Jamison KR, Goodwin F (1990) Suicide. In: Goodwin FK, Jamison KR (eds) Manic-depressive illness. Oxford University Press, New York, pp 227–244

    Google Scholar 

  • Goossens PJ, Van Wijngaarden B, Knoppert-van Der Klein EA, Van Achterberg T (2008) Family caregiving in bipolar disorder: caregiver consequences, caregiver coping styles, and caregiver distress. Int J Soc Psychiatry 54(4):303–316

    CAS  PubMed  Google Scholar 

  • Grad J, Sainbury M (1963) Evaluating a community care service. In: Freeman H, Farndale J (eds) Trends in mental health services. Pergamon Press, Oxford

    Google Scholar 

  • Grad J, Sainsbury P (1963) Mental illness and the family. Lancet 1(7280):544–547

    CAS  PubMed  Google Scholar 

  • Greene BL, Lustig N, Lee RR (1976) Marital therapy when one spouse has a primary affective disorder. Am J Psychiatry 133(7):827–830

    CAS  PubMed  Google Scholar 

  • Grover S, Chakrabarti S, Aggarwal M, Avasthi A, Kulhara P, Sharma S, Khehra N (2012) Comparative study of the experience of caregiving in bipolar affective disorder and schizophrenia. Int J Soc Psychiatry 58(6):614–622. doi:10.1177/0020764011419054

    PubMed  Google Scholar 

  • Gutierrez-Rojas L, Jurado D, Gurpegui M (2010) Factors associated with work, social life and family life disability in bipolar disorder patients. Psychiatry Res 186(2–3):254–260. doi:10.1016/j.psychres.2010.06.020, S0165-1781(10)00362-8 [pii]

    PubMed  Google Scholar 

  • Guze SB, Robins E (1970) Suicide and primary affective disorders. Br J Psychiatry 117(539):437–438

    CAS  PubMed  Google Scholar 

  • Harrow M, Goldberg JF, Grossman LS, Meltzer HY (1990) Outcome in manic disorders. A naturalistic follow-up study. Arch Gen Psychiatry 47(7):665–671

    CAS  PubMed  Google Scholar 

  • Heru AM, Ryan CE (2004) Burden, reward and family functioning of caregivers for relatives with mood disorders: 1-year follow-up. J Affect Disord 83(2–3):221–225. doi:10.1016/j.jad.2004.04.013

    PubMed  Google Scholar 

  • Hill RG, Shepherd G, Hardy P (1998) In sickness and in health: the experiences of friends and relatives caring for people with manic depression. J Ment Health 7:611–620

    Google Scholar 

  • Hoenig J, Hamilton MW (1966) The schizophrenic patient in the community and his effect on the household. Int J Soc Psychiatry 12(3):165–176

    CAS  PubMed  Google Scholar 

  • Hoenig J, Hamilton M (1969) The desegregation of the mentally ill. Routledge and Keegan-Paul, London

    Google Scholar 

  • Honig A, Hofman A, Rozendaal N, Dingemans P (1997) Psycho-education in bipolar disorder: effect on expressed emotion. Psychiatry Res 72(1):17–22, S0165-1781(97)00072-3 [pii]

    CAS  PubMed  Google Scholar 

  • Huxley N, Baldessarini RJ (2007) Disability and its treatment in bipolar disorder patients. Bipolar Disord 9(1–2):183–196. doi:10.1111/j.1399-5618.2007.00430.x

    PubMed  Google Scholar 

  • Janowsky DS, Leff M, Epstein RS (1970) Playing the manic game. Interpersonal maneuvers of the acutely manic patient. Arch Gen Psychiatry 22(3):252–261

    CAS  PubMed  Google Scholar 

  • Johnson ED (2000) Differences among families coping with serious mental illness: a qualitative analysis. Am J Orthopsychiatry 70(1):126–134

    CAS  PubMed  Google Scholar 

  • Judd LL, Akiskal HS (2003) The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases. J Affect Disord 73(1–2):123–131, S0165032702003324 [pii]

    PubMed  Google Scholar 

  • Judd LL, Akiskal HS, Schettler PJ, Endicott J, Leon AC, Solomon DA, Coryell W, Maser JD, Keller MB (2005) Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study. Arch Gen Psychiatry 62(12):1322–1330. doi:10.1001/archpsyc.62.12.1322, 62/12/1322 [pii]

    PubMed  Google Scholar 

  • Judd LL, Schettler PJ, Solomon DA, Maser JD, Coryell W, Endicott J, Akiskal HS (2008) Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders. J Affect Disord 108(1–2):49–58. doi:10.1016/j.jad.2007.06.014, S0165-0327(07)00333-3 [pii]

    PubMed  Google Scholar 

  • Katon W (1984) Depression: relationship to somatization and chronic medical illness. J Clin Psychiatry 45(3 Pt 2):4–12

    CAS  PubMed  Google Scholar 

  • Kauer-Sant’Anna M, Bond DJ, Lam RW, Yatham LN (2009) Functional outcomes in first-episode patients with bipolar disorder: a prospective study from the Systematic Treatment Optimization Program for Early Mania project. Compr Psychiatry 50(1):1–8. doi:10.1016/j.comppsych.2008.05.013, S0010-440X(08)00084-9 [pii]

    PubMed  Google Scholar 

  • Keck PE Jr, McElroy SL, Strakowski SM, West SA, Sax KW, Hawkins JM, Bourne ML, Haggard P (1998) 12-month outcome of patients with bipolar disorder following hospitalization for a manic or mixed episode. Am J Psychiatry 155(5):646–652

    PubMed  Google Scholar 

  • Kennedy N, Foy K, Sherazi R, McDonough M, McKeon P (2007) Long-term social functioning after depression treated by psychiatrists: a review. Bipolar Disord 9(1–2):25–37. doi:10.1111/j.1399-5618.2007.00326.x

    PubMed  Google Scholar 

  • Kessler RC, Walters EE, Forthofer MS (1998) The social consequences of psychiatric disorders, III: probability of marital stability. Am J Psychiatry 155(8):1092–1096

    CAS  PubMed  Google Scholar 

  • Kleinman L, Lowin A, Flood E, Gandhi G, Edgell E, Revicki D (2003) Costs of bipolar disorder. Pharmacoeconomics 21(9):601–622, 2191 [pii]

    PubMed  Google Scholar 

  • Kraepelin E (1921) Manic-depressive insanity and paranoia. Livingstone, Edinburgh

    Google Scholar 

  • Kusznir A, Cooke RG, Young LT (2000) The correlates of community functioning in patients with bipolar disorder. J Affect Disord 61(1–2):81–85, S0165-0327(99)00193-7 [pii]

    CAS  PubMed  Google Scholar 

  • Lam D, Donaldson C, Brown Y, Malliaris Y (2005) Burden and marital and sexual satisfaction in the partners of bipolar patients. Bipolar Disord 7(5):431–440. doi:10.1111/j.1399-5618.2005.00240.x

    PubMed  Google Scholar 

  • Langtree I (2014) Definitions of the models of disability. http://www.disabled-world.com/definitions/disability-models.php. 2014

  • Leclerc C, Lesage A, Ricard N (1997) Relevance of the stress-coping paradigm in the elaboration of a stress management model for schizophrenics. Sante Ment Que 22(2):233–256

    CAS  PubMed  Google Scholar 

  • Levy B, Medina AM, Hintz K, Weiss RD (2010) Ecologically valid support for the link between cognitive and psychosocial functioning in bipolar disorder. Psychiatry Res 185(3):353–357. doi:10.1016/j.psychres.2010.06.010, S0165-1781(10)00352-5 [pii]

    PubMed Central  PubMed  Google Scholar 

  • Link BG, Struening EL, Rahav M, Phelan JC, Nuttbrock L (1997) On stigma and its consequences: evidence from a longitudinal study of men with dual diagnoses of mental illness and substance abuse. J Health Soc Behav 38(2):177–190

    CAS  PubMed  Google Scholar 

  • Link BG, Struening EL, Neese-Todd S, Asmussen S, Phelan JC (2001) Stigma as a barrier to recovery: the consequences of stigma for the self-esteem of people with mental illnesses. Psychiatr Serv 52(12):1621–1626

    CAS  PubMed  Google Scholar 

  • Lopez AD (2005) The evolution of the global burden of disease framework for disease, injury and risk factor quantification: developing the evidence base for national, regional and global public health action. Glob Health 1(1):5. doi:10.1186/1744-8603-1-5

    Google Scholar 

  • Lowery K, Mynt P, Aisbett J, Dixon T, O’Brien J, Ballard C (2000) Depression in the carers of dementia sufferers: a comparison of the carers of patients suffering from dementia with Lewy bodies and the carers of patients with Alzheimer’s disease. J Affect Disord 59(1):61–65, S0165-0327(99)00123-8 [pii]

    CAS  PubMed  Google Scholar 

  • MacQueen GM, Young LT, Robb JC, Cooke RG, Joffe RT (1997) Levels of functioning and well-being in recovered psychotic versus nonpsychotic mania. J Affect Disord 46(1):69–72

    CAS  PubMed  Google Scholar 

  • MacQueen GM, Young LT, Robb JC, Marriott M, Cooke RG, Joffe RT (2000) Effect of number of episodes on wellbeing and functioning of patients with bipolar disorder. Acta Psychiatr Scand 101(5):374–381

    CAS  PubMed  Google Scholar 

  • MacQueen GM, Young LT, Joffe RT (2001) A review of psychosocial outcome in patients with bipolar disorder. Acta Psychiatr Scand 103(3):163–170

    CAS  PubMed  Google Scholar 

  • Magliano L, Orrico A, Fiorillo A, Del Vecchio H, Castiello G, Malangone C, De Rosa C, Capuano V, Maj M, Torchio E, Franzoi V, Pingani L, Curti C, Spanarello S, Scattina M, Fuchs H, Test GR, Ferrigno J, Minciotti E, Innocente P, Bardicchia F, Galli A, La Rovere R, Maroncelli M, Iapichino S, Pannozzo M, Nuccetelli F, Di Nunzio R, Armellino R, Palladino C, Delcuratolo V, Cadoni M, Cannas A, Caniglia A, Cudia M (2009) Family burden in bipolar disorders: results from the Italian Mood Disorders Study (IMDS). Epidemiol Psichiatr Soc 18(2):137–146

    PubMed  Google Scholar 

  • Maji KR, Sood M, Sagar R, Khandelwal SK (2011) A follow-up study of family burden in patients with bipolar affective disorder. Int J Soc Psychiatry. doi:10.1177/0020764010390442, 0020764010390442 [pii]

    PubMed  Google Scholar 

  • Marangell LB (2004) The importance of subsyndromal symptoms in bipolar disorder. J Clin Psychiatry 65(Suppl 10):24–27

    PubMed  Google Scholar 

  • Marneros A, Deister A, Rohde A (1990) Psychopathological and social status of patients with affective, schizophrenic and schizoaffective disorders after long-term course. Acta Psychiatr Scand 82(5):352–358

    CAS  PubMed  Google Scholar 

  • Martinez-Aran A, Vieta E, Colom F, Reinares M, Benabarre A, Torrent C, Goikolea JM, Corbella B, Sanchez-Moreno J, Salamero M (2002) Neuropsychological performance in depressed and euthymic bipolar patients. Neuropsychobiology 46(Suppl 1):16–21

    PubMed  Google Scholar 

  • Martinez-Aran A, Vieta E, Colom F, Torrent C, Sanchez-Moreno J, Reinares M, Benabarre A, Goikolea JM, Brugue E, Daban C, Salamero M (2004) Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome. Bipolar Disord 6(3):224–232. doi:10.1111/j.1399-5618.2004.00111.x

    CAS  PubMed  Google Scholar 

  • Martinez-Aran A, Vieta E, Torrent C, Sanchez-Moreno J, Goikolea JM, Salamero M, Malhi GS, Gonzalez-Pinto A, Daban C, Alvarez-Grandi S, Fountoulakis K, Kaprinis G, Tabares-Seisdedos R, Ayuso-Mateos JL (2007) Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar Disord 9(1–2):103–113. doi:10.1111/j.1399-5618.2007.00327.x

    CAS  PubMed  Google Scholar 

  • McCarthy JF, Valenstein M, Zivin K, Zeber JE, Kilbourne AM (2010) Access-related measures and out-of-system utilization among veterans with bipolar disorder. Psychiatr Serv 61(10):1035–1038. doi:10.1176/appi.ps.61.10.1035, 61/10/1035 [pii]

    PubMed  Google Scholar 

  • McIntyre RS, Wilkins K, Gilmour H, Soczynska JK, Konarksi JZ, Miranda A, Woldeyohannes HO, Vagic D, Alsuwaidan M, Kennedy SH (2008) The effect of bipolar I disorder and major depressive disorder on workforce function. Chronic Dis Can 28(3):84–91

    CAS  PubMed  Google Scholar 

  • McMorris BJ, Downs KE, Panish JM, Dirani R (2009) Workplace productivity, employment issues, and resource utilization in patients with bipolar I disorder. J Med Econ 13(1):23–32. doi:10.3111/13696990903475833

    Google Scholar 

  • McPherson HM, Dore GM, Loan PA, Romans SE (1992) Socioeconomic characteristics of a Dunedin sample of bipolar patients. N Z Med J 105(933):161–162

    CAS  PubMed  Google Scholar 

  • Michalak EE, Murray G, Young AH, Lam RW (2008) Burden of bipolar depression: impact of disorder and medications on quality of life. CNS Drugs 22(5):389–406, 2253 [pii]

    PubMed  Google Scholar 

  • Michalak E, Livingston JD, Hole R, Suto M, Hale S, Haddock C (2011) ‘It’s something that I manage but it is not who I am’: reflections on internalized stigma in individuals with bipolar disorder. Chronic Illn 7(3):209–224. doi:10.1177/1742395310395959, 1742395310395959 [pii]

    PubMed  Google Scholar 

  • Miklowitz DJ, Taylor DO (2006) Family-focused treatment of the suicidal bipolar patient. Bipolar Disord 8(5 Pt 2):640–651

    PubMed  Google Scholar 

  • Miklowitz DJ, George EL, Richards JA, Simoneau TL, Suddath RL (2003) A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder. Arch Gen Psychiatry 60(9):904–912. doi:10.1001/archpsyc.60.9.904

    PubMed  Google Scholar 

  • Morgan VA, Mitchell PB, Jablensky AV (2005) The epidemiology of bipolar disorder: sociodemographic, disability and service utilization data from the Australian National Study of Low Prevalence (Psychotic) Disorders. Bipolar Disord 7(4):326–337. doi:10.1111/j.1399-5618.2005.00229.x, BDI229 [pii]

    PubMed  Google Scholar 

  • Morselli PL, Elgie R, Cesana BM (2004) GAMIAN-Europe/BEAM survey II: cross-national analysis of unemployment, family history, treatment satisfaction and impact of the bipolar disorder on life style. Bipolar Disord 6(6):487–497. doi:10.1111/j.1399-5618.2004.00160.x

    CAS  PubMed  Google Scholar 

  • Mueser KT, Webb C, Pfeiffer M, Gladis M, Levinson DF (1996) Family burden of schizophrenia and bipolar disorder: perceptions of relatives and professionals. Psychiatr Serv 47(5):507–511

    CAS  PubMed  Google Scholar 

  • Mur M, Portella MJ, Martinez-Aran A, Pifarre J, Vieta E (2009) Influence of clinical and neuropsychological variables on the psychosocial and occupational outcome of remitted bipolar patients. Psychopathology 42(3):148–156. doi:10.1159/000207456, 000207456 [pii]

    PubMed  Google Scholar 

  • Murray CJL, Lopez AD (eds) (1996) The global burden of disease. A comprehensive assessment of the mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Harvard School of Public Health on behalf of the World Health Organisation, and the World Bank, Boston

    Google Scholar 

  • Nadkarni RB, Fristad MA (2012) Stress and support for parents of youth with bipolar disorder. Isr J Psychiatry Relat Sci 49(2):104–110

    PubMed  Google Scholar 

  • Nehra R, Chakrabarti S, Kulhara P, Sharma R (2005) Caregiver-coping in bipolar disorder and schizophrenia–a re-examination. Soc Psychiatry Psychiatr Epidemiol 40(4):329–336. doi:10.1007/s00127-005-0884-3

    PubMed  Google Scholar 

  • Nehra R, Chakrabarti S, Pradhan BK, Khehra N (2006) Comparison of cognitive functions between first- and multi-episode bipolar affective disorders. J Affect Disord 93(1–3):185–192. doi:10.1016/j.jad.2006.03.013, S0165-0327(06)00139-X [pii]

    PubMed  Google Scholar 

  • O’Connell RA, Mayo JA, Flatow L, Cuthbertson B, O’Brien BE (1991) Outcome of bipolar disorder on long-term treatment with lithium. Br J Psychiatry 159:123–129

    PubMed  Google Scholar 

  • Ogilvie AD, Morant N, Goodwin GM (2005) The burden on informal caregivers of people with bipolar disorder. Bipolar Disord 7(Suppl 1):25–32. doi:10.1111/j.1399-5618.2005.00191.x

    PubMed  Google Scholar 

  • Ohaeri JU, Fido AA (2001) The opinion of caregivers on aspects of schizophrenia and major affective disorders in a Nigerian setting. Soc Psychiatry Psychiatr Epidemiol 36(10):493–499

    CAS  PubMed  Google Scholar 

  • Olie JP, Levy E (2002) Manic episodes: the direct cost of a three-month period following hospitalisation. Eur Psychiatry 17(5):278–286, S0924933802006806 [pii]

    CAS  PubMed  Google Scholar 

  • Ostacher MJ, Nierenberg AA, Iosifescu DV, Eidelman P, Lund HG, Ametrano RM, Kaczynski R, Calabrese J, Miklowitz DJ, Sachs GS, Perlick DA (2008) Correlates of subjective and objective burden among caregivers of patients with bipolar disorder. Acta Psychiatr Scand 118(1):49–56. doi:10.1111/j.1600-0447.2008.01201.x

    CAS  PubMed  Google Scholar 

  • Ozer S, Ulusahin A, Batur S, Kabakci E, Saka MC (2002) Outcome measures of interepisode bipolar patients in a Turkish sample. Soc Psychiatry Psychiatr Epidemiol 37(1):31–37

    PubMed  Google Scholar 

  • Peele PB, Xu Y, Kupfer DJ (2003) Insurance expenditures on bipolar disorder: clinical and parity implications. Am J Psychiatry 160(7):1286–1290

    PubMed  Google Scholar 

  • Perlick D, Clarkin JF, Sirey J, Raue P, Greenfield S, Struening E, Rosenheck R (1999) Burden experienced by care-givers of persons with bipolar affective disorder. Br J Psychiatry 175:56–62

    CAS  PubMed  Google Scholar 

  • Perlick D, Rosenheck RR, Clarkin JF, Raue P, Sirey J (2001) Impact of family burden and patient symptom status on clinical outcome in bipolar affective disorder. J Nerv Ment Dis 189(1):31–37

    CAS  PubMed  Google Scholar 

  • Perlick D, Rosenheck RA, Clarkin JF, Maciejewski PK, Sirey J, Struening E, Link BG (2004) Impact of family burden and affective response on clinical outcome among patients with bipolar disorder. Psychiatr Serv 55(9):1029–1035. doi:10.1176/appi.ps.55.9.1029

    PubMed  Google Scholar 

  • Perlick D, Hohenstein JM, Clarkin JF, Kaczynski R, Rosenheck RA (2005) Use of mental health and primary care services by caregivers of patients with bipolar disorder: a preliminary study. Bipolar Disord 7(2):126–135. doi:10.1111/j.1399-5618.2004.00172.x

    PubMed  Google Scholar 

  • Perlick D, Miklowitz DJ, Link BG, Struening E, Kaczynski R, Gonzalez J, Manning LN, Wolff N, Rosenheck RA (2007a) Perceived stigma and depression among caregivers of patients with bipolar disorder. Br J Psychiatry 190:535–536. doi:10.1192/bjp.bp.105.020826

    PubMed  Google Scholar 

  • Perlick D, Rosenheck RA, Miklowitz DJ, Chessick C, Wolff N, Kaczynski R, Ostacher M, Patel J, Desai R (2007b) Prevalence and correlates of burden among caregivers of patients with bipolar disorder enrolled in the systematic treatment enhancement program for bipolar disorder. Bipolar Disord 9(3):262–273. doi:10.1111/j.1399-5618.2007.00365.x

    PubMed  Google Scholar 

  • Perlick D, Rosenheck RA, Miklowitz DJ, Kaczynski R, Link B, Ketter T, Wisniewski S, Wolff N, Sachs G (2008) Caregiver burden and health in bipolar disorder: a cluster analytic approach. J Nerv Ment Dis 196(6):484–491. doi:10.1097/NMD.0b013e3181773927

    PubMed Central  PubMed  Google Scholar 

  • Perlick DA, Miklowitz DJ, Lopez N, Chou J, Kalvin C, Adzhiashvili V, Aronson A (2010) Family-focused treatment for caregivers of patients with bipolar disorder. Bipolar Disord 12(6):627–637. doi:10.1111/j.1399-5618.2010.00852.x

    PubMed Central  PubMed  Google Scholar 

  • Pini S, de Queiroz V, Pagnin D, Pezawas L, Angst J, Cassano GB, Wittchen HU (2005) Prevalence and burden of bipolar disorders in European countries. Eur Neuropsychopharmacol 15(4):425–434. doi:10.1016/j.euroneuro.2005.04.011, S0924-977X(05)00074-X [pii]

    CAS  PubMed  Google Scholar 

  • Platt S (1985) Measuring the burden of psychiatric illness on the family: an evaluation of some rating scales. Psychol Med 15(2):383–393

    CAS  PubMed  Google Scholar 

  • Pompili M, Rihmer Z, Innamorati M, Lester D, Girardi P, Tatarelli R (2009) Assessment and treatment of suicide risk in bipolar disorders. Expert Rev Neurother 9(1):109–136. doi:10.1586/14737175.9.1.109

    PubMed  Google Scholar 

  • Pompili M, Harnic D, Gonda X, Forte A, Dominici G, Innamorati M, Fountoulakis KN, Serafini G, Sher L, Janiri L, Rihmer Z, Amore M, Girardi P (2014) Impact of living with bipolar patients: making sense of caregivers’ burden. World J Psychiatry 4(1):1–12. doi:10.5498/wjp.v4.i1.1

    PubMed Central  PubMed  Google Scholar 

  • Pope M, Dudley R, Scott J (2007) Determinants of social functioning in bipolar disorder. Bipolar Disord 9(1–2):38–44. doi:10.1111/j.1399-5618.2007.00323.x

    PubMed  Google Scholar 

  • Poulin MJ, Brown SL, Ubel PA, Smith DM, Jankovic A, Langa KM (2010) Does a helping hand mean a heavy heart? Helping behavior and well-being among spouse caregivers. Psychol Aging 25(1):108–117. doi:10.1037/a0018064

    PubMed Central  PubMed  Google Scholar 

  • Practice guideline for the assessment and treatment of patients with suicidal behaviors (2003) Am J Psychiatry 160(11 Suppl):1–60

    Google Scholar 

  • Pradhan SC, Sinha VK, Singh TB (1999) Psycho-social dysfunctions in patients after recovery from mania and depression. Int J Rehabil Res 22(4):303–309

    CAS  PubMed  Google Scholar 

  • Priebe S, Wildgrube C, Muller-Oerlinghausen B (1989) Lithium prophylaxis and expressed emotion. Br J Psychiatry 154:396–399

    CAS  PubMed  Google Scholar 

  • Raveendranathan D, Chandra PS, Chaturvedi SK (2012) Violence among psychiatric inpatients: a victim’s perspective. East Asian Arch Psychiatry 22(4):141–145

    CAS  PubMed  Google Scholar 

  • Reinares M, Vieta E, Colom F, Martinez-Aran A, Torrent C, Comes M, Goikolea JM, Benabarre A, Sanchez-Moreno J (2004) Impact of a psychoeducational family intervention on caregivers of stabilized bipolar patients. Psychother Psychosom 73(5):312–319. doi:10.1159/00007884878848

    CAS  PubMed  Google Scholar 

  • Reinares M, Vieta E, Colom F, Martinez-Aran A, Torrent C, Comes M, Goikolea JM, Benabarre A, Daban C, Sanchez-Moreno J (2006) What really matters to bipolar patients’ caregivers: sources of family burden. J Affect Disord 94(1–3):157–163. doi:10.1016/j.jad.2006.04.022

    CAS  PubMed  Google Scholar 

  • Reznik I, Sirota P (1999) Premorbid social functioning with schizophrenia and bipolar disorder. Am J Psychiatry 156(6):986

    CAS  PubMed  Google Scholar 

  • Rosa AR, Reinares M, Michalak EE, Bonnin CM, Sole B, Franco C, Comes M, Torrent C, Kapczinski F, Vieta E (2011) Functional impairment and disability across mood states in bipolar disorder. Value Health 13(8):984–988. doi:10.1111/j.1524-4733.2010.00768.x, VHE768 [pii]

    Google Scholar 

  • Sachs GS, Nierenberg AA, Calabrese JR, Marangell LB, Wisniewski SR, Gyulai L, Friedman ES, Bowden CL, Fossey MD, Ostacher MJ, Ketter TA, Patel J, Hauser P, Rapport D, Martinez JM, Allen MH, Miklowitz DJ, Otto MW, Dennehy EB, Thase ME (2007) Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med 356(17):1711–1722. doi:10.1056/NEJMoa064135

    CAS  PubMed  Google Scholar 

  • Sales E (2003) Family burden and quality of life. Qual Life Res 12(Suppl 1):33–41

    PubMed  Google Scholar 

  • Sanchez-Moreno J, Martinez-Aran A, Tabares-Seisdedos R, Torrent C, Vieta E, Ayuso-Mateos JL (2009) Functioning and disability in bipolar disorder: an extensive review. Psychother Psychosom 78(5):285–297. doi:10.1159/000228249, 000228249 [pii]

    CAS  PubMed  Google Scholar 

  • Schoeyen HK, Birkenaes AB, Vaaler AE, Auestad BH, Malt UF, Andreassen OA, Morken G (2011a) Bipolar disorder patients have similar levels of education but lower socio-economic status than the general population. J Affect Disord 129(1–3):68–74, S0165-0327(10)00546-X [pii]

    PubMed  Google Scholar 

  • Schoeyen HK, Vaaler AE, Auestad BH, Malt UF, Melle I, Andreassen OA, Morken G (2011b) Despite clinical differences, bipolar disorder patients from acute wards and outpatient clinics have similar educational and disability levels compared to the general population. J Affect Disord 132(1–2):209–215. doi:10.1016/j.jad.2011.02.025, S0165-0327(11)00079-6 [pii]

    PubMed  Google Scholar 

  • Simon GE (2002) Why we care about the economic and social burden of bipolar disorder. In: Maj M, Akiskal H, Lopez- Ibor JJ, Sartorius N (eds) Bipolar disorder-WPA series on evidence and experience in psychiatry. Wiley, London, pp 474–476

    Google Scholar 

  • Simon GE (2003) Social and economic burden of mood disorders. Biol Psychiatry 54(3):208–215, S0006322303004207 [pii]

    PubMed  Google Scholar 

  • Simon GE, Bauer MS, Ludman EJ, Operskalski BH, Unutzer J (2007) Mood symptoms, functional impairment, and disability in people with bipolar disorder: specific effects of mania and depression. J Clin Psychiatry 68(8):1237–1245

    PubMed  Google Scholar 

  • Steele A, Maruyama N, Galynker I (2009) Psychiatric symptoms in caregivers of patients with bipolar disorder: a review. J Affect Disord 121(1–2):10–21. doi:10.1016/j.jad.2009.04.020, S0165-0327(09)00171-2 [pii]

    PubMed  Google Scholar 

  • Stender M, Bryant-Comstock L, Phillips S (2002) Medical resource use among patients treated for bipolar disorder: a retrospective, cross-sectional, descriptive analysis. Clin Ther 24(10):1668–1676, S0149291802800704 [pii]

    PubMed  Google Scholar 

  • Struening EL, Perlick DA, Link BG, Hellman F, Herman D, Sirey JA (2001) Stigma as a barrier to recovery: The extent to which caregivers believe most people devalue consumers and their families. Psychiatr Serv 52(12):1633–1638

    CAS  PubMed  Google Scholar 

  • Stueve A, Vine P, Struening EL (1997) Perceived burden among caregivers of adults with serious mental illness: comparison of black, Hispanic, and white families. Am J Orthopsychiatry 67(2):199–209

    CAS  PubMed  Google Scholar 

  • Szmukler GI, Burgess P, Herrman H, Benson A, Colusa S, Bloch S (1996) Caring for relatives with serious mental illness: the development of the experience of caregiving inventory. Soc Psychiatry Psychiatr Epidemiol 31(3–4):137–148

    CAS  PubMed  Google Scholar 

  • Tabares-Seisdedos R, Balanza-Martinez V, Sanchez-Moreno J, Martinez-Aran A, Salazar-Fraile J, Selva-Vera G, Rubio C, Mata I, Gomez-Beneyto M, Vieta E (2008) Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. J Affect Disord 109(3):286–299. doi:10.1016/j.jad.2007.12.234, S0165-0327(08)00015-3 [pii]

    PubMed  Google Scholar 

  • Tantum D (1989) Familial factors in psychiatric disorder. Curr Opin Psychiatry 2:296–301

    Google Scholar 

  • Targum SD, Dibble ED, Davenport YB, Gershon ES (1981) The family attitudes questionnaire. Patients’ and spouses’ views of bipolar illness. Arch Gen Psychiatry 38(5):562–568

    CAS  PubMed  Google Scholar 

  • Tohen M, Waternaux CM, Tsuang MT (1990) Outcome in mania. A 4-year prospective follow-up of 75 patients utilizing survival analysis. Arch Gen Psychiatry 47(12):1106–1111

    CAS  PubMed  Google Scholar 

  • Tohen M, Greenfield SF, Weiss RD, Zarate CA Jr, Vagge LM (1998) The effect of comorbid substance use disorders on the course of bipolar disorder: a review. Harv Rev Psychiatry 6(3):133–141

    CAS  PubMed  Google Scholar 

  • Tohen M, Hennen J, Zarate CM Jr, Baldessarini RJ, Strakowski SM, Stoll AL, Faedda GL, Suppes T, Gebre-Medhin P, Cohen BM (2000) Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features. Am J Psychiatry 157(2):220–228

    CAS  PubMed  Google Scholar 

  • Tranvag O, Kristoffersen K (2008) Experience of being the spouse/cohabitant of a person with bipolar affective disorder: a cumulative process over time. Scand J Caring Sci 22(1):5–18. doi:10.1111/j.1471-6712.2007.00562.x

    PubMed  Google Scholar 

  • Trippitelli CL, Jamison KR, Folstein MF, Bartko JJ, DePaulo JR (1998) Pilot study on patients’ and spouses’ attitudes toward potential genetic testing for bipolar disorder. Am J Psychiatry 155(7):899–904

    CAS  PubMed  Google Scholar 

  • Vazquez GH, Kapczinski F, Magalhaes PV, Cordoba R, Lopez Jaramillo C, Rosa AR, Sanchez De Carmona M, Tohen M (2010) Stigma and functioning in patients with bipolar disorder. J Affect Disord 130(1-2):323–327. doi:10.1016/j.jad.2010.10.012, S0165-0327(10)00626-9 [pii]

    PubMed  Google Scholar 

  • Veltman A, Cameron J, Stewart DE (2002) The experience of providing care to relatives with chronic mental illness. J Nerv Ment Dis 190(2):108–114

    PubMed  Google Scholar 

  • Vieta E (2005) Improving treatment adherence in bipolar disorder through psychoeducation. J Clin Psychiatry 66(Suppl 1):24–29

    PubMed  Google Scholar 

  • Wilson L, Crowe M (2009) Parenting with a diagnosis bipolar disorder. J Adv Nurs 65(4):877–884. doi:10.1111/j.1365-2648.2008.04954.x

    PubMed  Google Scholar 

  • Wingo AP, Baldessarini RJ, Compton MT, Harvey PD (2010) Correlates of recovery of social functioning in types I and II bipolar disorder patients. Psychiatry Res 177(1–2):131–134. doi:10.1016/j.psychres.2010.02.020, S0165-1781(10)00094-6 [pii]

    PubMed Central  PubMed  Google Scholar 

  • Wolff N, Perlick DA, Kaczynski R, Calabrese J, Nierenberg A, Miklowitz DJ (2006) Modeling costs and burden of informal caregiving for persons with bipolar disorder. J Ment Health Policy Econ 9(2):99–110

    PubMed  Google Scholar 

  • World Health Organization (1999) Annual report. World Health Organization, Geneva

    Google Scholar 

  • World Health Organization (2001) International classification of functioning, disability and health. WHO, Geneva

    Google Scholar 

  • World Health Organization (2011) World report on disability. WHO, Geneva

    Google Scholar 

  • World Health Organization (2014) Disability. http://www.who.int/topics/disabilities/en/. 2014

  • Young AH, Rigney U, Shaw S, Emmas C, Thompson JM (2011) Annual cost of managing bipolar disorder to the UK healthcare system. J Affect Disord 133(3):450–456. doi:10.1016/j.jad.2011.06.016, S0165-0327(11)00335-1 [pii]

    PubMed  Google Scholar 

  • Zarate CA Jr, Tohen M, Land M, Cavanagh S (2000) Functional impairment and cognition in bipolar disorder. Psychiatry Q 71(4):309–329

    Google Scholar 

  • Zubieta JK, Huguelet P, O’Neil RL, Giordani BJ (2001) Cognitive function in euthymic bipolar I disorder. Psychiatry Res 102(1):9–20

    CAS  PubMed  Google Scholar 

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    Kostas N. Fountoulakis

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Fountoulakis, K.N. (2015). Disability and Overall Burden Related with Bipolar Disorder. In: Bipolar Disorder. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37216-2_12

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