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The Glycocode: Translating Heparan Sulfate Fine Structure into Developmental Function

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Extracellular Matrix in Development

Part of the book series: Biology of Extracellular Matrix ((BEM))

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Abstract

Heparan sulfate proteoglycans (HSPGs) are an important component of the cell surface and extracellular matrix. HSPGs function in a wide variety of biological processes, including cell adhesion, signaling, migration, and proliferation. HSPGs are an information-dense family consisting of a core protein to which one or more glycosaminoglycan (GAG) chains are attached. The information contained within the GAG chains allows for great complexity and a specificity to bind and regulate binding of growth factors and morphogens. It is therefore no surprise that HSPGs are involved in many developmental processes, such as neural migration, kidney formation, and placentation. Here we explore how the information-rich GAG chains control distinct aspects of development utilizing a “glycocode” model.

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Authors and Affiliations

  1. Department of Molecular, Cellular and Developmental Biology, University of Colorado, 1945 Colorado Avenue, Boulder, CO, 80309, USA

    Adam B. Cadwallader

  2. Department of Neurobiology and Anatomy, Eccles Institute of Human Genetics, University of Utah School of Medicine, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, UT, 84112-5330, USA

    H. Joseph Yost

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Editors and Affiliations

  1. School of Medicine, Department of Cell Biology, University of Virginia, Jeanette Lancaster Way 200, Charlottesville, 22903, Virginia, USA

    Douglas W. DeSimone

  2. School of Medicine, Dept. Cell Biology & Physiology, Washington University, South Euclid Avenue 660, St. Louis, 63110, Missouri, USA

    Robert P. Mecham

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Cadwallader, A.B., Yost, H.J. (2013). The Glycocode: Translating Heparan Sulfate Fine Structure into Developmental Function. In: DeSimone, D., Mecham, R. (eds) Extracellular Matrix in Development. Biology of Extracellular Matrix. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35935-4_1

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