Abstract
Venous thromboembolism (VTE) is a common medical condition in the elderly that includes both deep vein thrombosis and pulmonary embolism (PE).
VTE clinical presentation is often nonspecific, and older patients are more likely to ignore symptoms thus leading to unrecognized and untreated cases. This chapter describes the current imaging techniques utilized for diagnosis, such as chest x-ray, lung scintigraphy, ultrasonography, and computed tomography. We also described two specific forms of PE: PE in acute COPD exacerbation and tumor embolism.
Pulmonary hypertension (PH) is a hemodynamic and pathophysiological state that can be found in multiple clinical conditions. The general radiological findings are discussed, with particular attention to computed tomography signs. We also describe the most common forms of PH in the elderly: PH associated with connective tissue disease, PH due to lung diseases and/or hypoxia, and PH secondary to left heart disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- COPD:
-
Chronic obstructive pulmonary disease
- CTD:
-
Connective tissue disease
- CTEPH:
-
Chronic thromboembolic pulmonary hypertension
- CTPA:
-
Computed tomography pulmonary angiography
- DVT:
-
Deep venous thrombosis
- HRCT:
-
High resolution computed tomography
- IPH:
-
Idiopathic pulmonary hypertension
- LV:
-
Left ventricle
- MDCT:
-
Multidetector computed tomography
- mPAP:
-
Mean pulmonary arterial pressure
- MRI:
-
Magnetic resonance imaging
- PE:
-
Pulmonary embolism
- PH:
-
Pulmonary hypertension
- PAH:
-
Pulmonary arterial hypertension
- PVOD:
-
Pulmonary veno-occlusive disease
- RV:
-
Right ventricle
- VTE:
-
Venous thromboembolic disease
References
Attinà D, Valentino M, Galiè N et al (2011) Application of a new pulmonary artery obstruction score in the prognostic evaluation of acute pulmonary embolism: comparison with clinical and haemodynamic parameters. Radiol Med 116:230–245
Bergin CJ, Rios G, King MA et al (1996) Accuracy of high-resolution CT in identifying chronic pulmonary thromboembolic disease. AJR Am J Roentgenol 166:1371–1377
Bugnone AN, Viamonte M Jr, Garcia H (2002) Imaging findings in human immunodeficiency virus-related pulmonary hypertension: report of five cases and review of the literature. Radiology 223:820–827
Chan CK, Hutcheon MA, Hyland RH et al (1987) Pulmonary tumor embolism: a critical review of clinical, imaging, and hemodynamic factors. J Thorac Imaging 2:4–14
Chaouat A, Bugnet AS, Kadaoui N et al (2005) Severe pulmonary hypertension and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 172:189–194
Cobelli R, Zompatori M, Bresciani P et al (2004) Visualization of hypoattenuation clots on unenhanced CT of the thorax. AJR Am J Roentgenol 182:530–531
Coche E, Verschuren F, Hainaut P et al (2004) Pulmonary embolism findings on chest radiographs and multislice spiral CT. Eur Radiol 14:1241–1248
Collomb D, Paramelle PJ, Calaque O et al (2003) Severity assessment of acute pulmonary embolism: evaluation using helical CT. Eur Radiol 13:1508–1514
Contractor S, Maldjian PD, Sharma VK et al (2002) Role of helical CT in detecting right ventricular dysfunction secondary to acute pulmonary embolism. J Comput Assist Tomogr 26:587–591
Corradi D, Mormandi F, Tanzi G et al (2006) Fatal cor pulmonale caused by pulmonary tumor microembolism in a patient with occult gastric cancer. Cardiovasc Pathol 15:157–160
Delgado JF, Conde E, Sanchez V et al (2005) Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure. Eur J Heart Fail 7:1011–1016
Devaraj A, Hansell DM (2009) Computed tomography signs of pulmonary hypertension: old and new observations. Clin Radiol 64:751–760
Devaraj A, Wells AU, Meister MG et al (2008) The effect of diffuse pulmonary fibrosis on the reliability of CT signs of pulmonary hypertension. Radiology 249:1042–1049
Elliot CG, Goldhaber SZ, Visani L et al (2000) Chest radiographs in acute pulmonary embolism. Results from the International Cooperative Pulmonary Embolism Registry. Chest 118:33–38
Franquet T, Giménez A, Prats R et al (2002) Thrombotic microangiopathy of pulmonary tumors: a vascular cause of tree-in-bud pattern on CT. AJR Am J Roentgenol 179:897–899
Galiè N, Hoeper MM, Humbert M et al (2009) Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 30:2493–2537
Ghanima W, Abdelnoor M, Holmen LO et al (2007) The association between the proximal extension of the clot and the severity of pulmonary embolism (PE): a proposal for a new radiological score for PE. J Intern Med 261:74–81
Ghaye B, Ghuysen A, Willems V et al (2006) Severe pulmonary embolism: pulmonary artery clot load scores and cardiovascular parameters as predictors of mortality. Radiology 239:884–891
Goldhaber SZ (2002) Echocardiography in the management of pulmonary embolism. Ann Intern Med 136:691–700
Griffin N, Allen D, Wort J et al (2007) Eisenmenger syndrome and idiopathic pulmonary arterial hypertension: do parenchymal lung changes reflect aetiology? Clin Radiol 62:587–595
Groves AM, Win T, Charman SC et al (2004) Semi-quantitative assessment of tricuspid regurgitation on contrast-enhanced multidetector CT. Clin Radiol 59:715–719
Hachulla E, Gressin V, Guillevin L et al (2005) Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study. Arthritis Rheum 52:3792–3800
Hoeper MM, Mayer E, Simonneau G et al (2006) Chronic thromboembolic pulmonary hypertension. Circulation 113:2011–2020
Horton MR, Tuder RM (2004) Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT. Crit Rev Comput Tomogr 45:335–341
Hull R, Raskob GE, Coates G et al (1990) Clinical validity of a normal perfusion lung scan in patients with suspected pulmonary embolism. Chest 97:23–26
Humbert M, Sitbon O, Chaouat A et al (2006) Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 173:1023–1030
Hyduk A, Croft JB, Ayala C et al (2005) Pulmonary hypertension surveillance – United States, 1980–2002. MMWR Surveill Summ 54:1–28
Iwakami S, Sato T, Takagi H et al (2009) An autopsy case of subacute cor pulmonale due to pulmonary tumor cell emboli in a patient with gastric cancer. Intern Med 48:1057–1060
Jyothula S, Safdar Z (2009) Update on pulmonary hypertension complicating chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 4:351–363
Kanne JP, Lalani TA (2004) Role of computed tomography and magnetic resonance imaging for deep venous thrombosis and pulmonary embolism. Circulation 109:l15–l21
Kanne JP, Thoongsuwan N, Stern EJ (2003) Detection of central pulmonary embolism on computed tomography densitometry images before computed tomography pulmonary angiography. J Comput Assist Tomogr 27:907–910
Kawut SM, Taichman DB, Archer-Chicko CL et al (2003) Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis. Chest 123:344–350
Kearon C, Ginsberg JS, Hirsh J (1998) The role of venous ultrasonography in the diagnosis of suspected deep venous thrombosis and pulmonary embolism. Ann Intern Med 129:1044–1049
King MA, Ysrael M, Bergin CJ (1998) Chronic thromboembolic pulmonary hypertension: CT findings. AJR Am J Roentgenol 170:955–960
Kniffin WD, Baron JA, Barrett J et al (1994) The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly. Arch Intern Med 154:861–866
Le Gal G, Righini M, Roy PM et al (2006a) Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med 144:165–171
Le Gal G, Righini M, Sanchez O et al (2006b) A positive compression ultrasonography of the lower limb veins is highly predictive of pulmonary embolism on computed tomography in suspected patients. Thromb Haemost 95:963–966
Lesser BA, Leeper KU Jr, Stein PD et al (1992) The diagnosis of acute pulmonary embolus in patients with chronic obstructive pulmonary disease. Chest 102:17–22
Masotti L, Ray P, Righini M et al (2008) Pulmonary embolism in the elderly: a review on clinical, instrumental and laboratory presentation. Vasc Health Risk Manag 4:629–636
Matsuoka S, Washko GR, Yamashiro T et al (2010) Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema. Am J Respir Crit Care Med 181:218–225
Minai OA, Chaouat A, Adnot S (2010) Pulmonary hypertension in COPD: epidemiology, significance, and management: pulmonary vascular disease: the global perspective. Chest 137(6 Suppl):39S–51S
Mispelaere D, Glerant JC, Audebert M et al (2002) Pulmonary embolism and sibilant types of chronic obstructive pulmonary disease decompensations. Rev Mal Respir 19:415–423
Mukerjee D, St George D, Coleiro B et al (2003) Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 62:1088–1093
Nakamura H, Adachi H, Sudoh A et al (2004) Subacute cor pulmonale due to tumor embolism. Intern Med 43:420–422
Ng CS, Wells AU, Padley SP (1999) A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter. J Thorac Imaging 14:270–278
Nolan RL, Mcadams HP, Sporn TA et al (1999) Pulmonary cholesterol granulomas in patients with pulmonary artery hypertension: chest radiographic and CT findings. AJR Am J Roentgenol 172:1317–1319
Oswald-Mammosser M, Apprill M, Bachez P et al (1991) Pulmonary hemodynamics in chronic obstructive pulmonary disease of the emphysematous type. Respiration 58:304–310
Oudiz RJ (2007) Pulmonary hypertension associated with left-sided heart disease. Clin Chest Med 28:233–241
Peacock AJ, Murphy NF, McMurray JJV et al (2007) An epidemiological study of pulmonary arterial hypertension. Eur Respir J 30:104–109
Qanadli SD, El Hajjam M, Vieillard-Baron A et al (2001) New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. AJR Am J Roentgenol 176:1415–1420
Quiroz R, Kucher N, Schoepf UJ et al (2004) Right ventricular enlargement on chest computed tomography: prognostic role in acute pulmonary embolism. Circulation 109:2401–2404
Remy-Jardin M, Remy J, Louvegny S et al (1997) Airway changes in chronic pulmonary embolism: CT findings in 33 patients. Radiology 203:355–360
Remy-Jardin M, Duhamel A, Deken V et al (2005) Systemic collateral supply in patients with chronic thromboembolic and primary pulmonary hypertension: assessment with multi-detector row helical CT angiography. Radiology 235:274–281
Remy-Jardin M, Pistolesi M, Goodman LR et al (2007) Management of suspected acute pulmonary embolism in the era of CT angiography: a statement of the Fleischner Society. Radiology 245:315–329
Riquet M (2007) Bronchial arteries and lymphatics of the lung. Thorac Surg Clin 17:619–638
Rizkallah J, Man SF, Sin DD (2009) Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysis. Chest 135:786–793
Roberts KE, Hamele-Bena D, Saqi A et al (2003) Pulmonary tumor embolism: a review of the literature. Am J Med 115:228–232
Rogers RL (2007) Venous thromboembolic disease in the elderly patient: atypical, subtle, and enigmatic. Clin Geriatr Med 23:413–423
Rutschmann OT, Cornuz J, Poletti PA et al (2007) Should pulmonary embolism be suspected in exacerbation of chronic obstructive pulmonary disease? Thorax 62:121–125
Ryan R, Abbara S, Colen RR et al (2008) Cardiac valve disease: spectrum of findings on cardiac 64-MDCT. AJR Am J Roentgenol 190:294–303
Schaefer-Prokop C, Prokop M (2005) MDCT for the diagnosis of acute pulmonary embolism. Eur Radiol 15(Suppl 4):D37–D41
Scharf SM, Iqbal M, Keller C et al (2002) Hemodynamic characterization of patients with severe emphysema. Am J Respir Crit Care Med 166:314–322
Schoepf UJ, Costello P (2004) CT angiography for diagnosis of pulmonary embolism: state of the art. Radiology 230:329–337
Sheehan R, Perloff JK, Fishbein MC et al (2005) Pulmonary neovascularity: a distinctive radiographic finding in Eisenmenger syndrome. Circulation 112:2778–2785
Sidney S, Sorel M, Quesenberry CP Jr et al (2005) COPD and incident cardiovascular disease hospitalizations and mortality: Kaiser Permanente Medical Care Program. Chest 128:2068–2075
Simmoneau G, Robbins IM, Beghetti M et al (2009) Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 54(Suppl. 1):S43–S54
Stein PD, Athanasoulis C, Alavi A et al (1992) Complication and validity of pulmonary angiography in acute pulmonary embolism. Circulation 85:462–468
Stein PD, Beemath A, Meyers FA (2007) Pulmonary embolism and deep venous thrombosis in hospitalized adults with chronic obstructive pulmonary disease. J Cardiovasc Med (Hagerstown) 8:253–257
Tan RT, Kuzo R, Goodman LR et al (1998) Utility of CT scan evaluation for predicting pulmonary hypertension in patients with parenchymal lung disease. Chest 113:1250–1256
Tardy B, Tardy-Poncet B, Viallon A et al (1998) Evaluation of D-dimer ELISA test in elderly patients with suspected pulmonary embolism. Thromb Haemost 79:38–41
The PIOPED Investigators (1990) Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED). JAMA 263:2753–2759
Tillie-Leblond I, Marquette CH, Perez T et al (2006) Pulmonary embolism in patients with unexplained exacerbation of chronic obstructive pulmonary disease: prevalence and risk factors. Ann Intern Med 44:390–396
Timmons S, Kingston M, Hussain M et al (2003) Pulmonary embolism: differences in presentation between older and younger patients. Age Ageing 32:601–605
Torbicki A, Perrier A, Konstantinides S et al (2008) Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 29:2276–2315
Van der Meer RW, Pattynama PM, van Strijen MJ et al (2005) Right ventricular dysfunction and pulmonary obstruction index at helical CT: prediction of clinical outcome during 3-month follow-up in patients with acute pulmonary embolism. Radiology 235:798–803
Wells PS, Ginsberg JS, Anderson DR et al (1998) Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med 129:997–1005
Wittram C, Maher MM, Yoo AJ et al (2004) CT angiography of pulmonary embolism: diagnostic criteria and causes of misdiagnosis. Radiographics 24:1219–1238
Wittram C, Maher MM, Halpern EF et al (2005) Attenuation of acute and chronic pulmonary emboli. Radiology 235:1050–1054
Yao DX, Flieder DB, Hoda SA (2001) Pulmonary tumor thrombotic microangiopathy: an often missed antemortem diagnosis. Arch Pathol Lab Med 125:304–305
Zisman DA, Karlamangla AS, Ross DJ et al (2007) High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Chest 132:773–779
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Zompatori, M., Attinà, D., Niro, F. (2013). Thromboembolic Disease and Pulmonary Hypertension. In: Guglielmi, G., Peh, W., Guermazi, A. (eds) Geriatric Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35579-0_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-35579-0_18
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-35578-3
Online ISBN: 978-3-642-35579-0
eBook Packages: MedicineMedicine (R0)