Skip to main content
SpringerLink
Log in

Stem Cells in Acute and Chronic Lung Injury: Building Evidence for Therapeutic Use

  • Chapter
Annual Update in Intensive Care and Emergency Medicine 2013

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM))

  • 2696 Accesses

Abstract

Beneficial effects of stem cells have been reported in experimental models of acute and chronic lung injury [1]. It has been suggested that both cell-to-cell contact and the release of soluble mediators by stem cells may play a role in promoting immune regulation and cell regeneration. Nevertheless, the mechanisms of stem cell action are not yet fully understood.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ingenito EP, Tsai L, Murthy S, Tyagi S, Mazan M, Hoffman A (2012) Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplant 21:175–189

    PubMed  Google Scholar 

  2. Garcia O, Carraro G, Navarro S et al (2012) Cell-based therapies for lung disease. Br Med Bull 101:147–161

    Article  PubMed  CAS  Google Scholar 

  3. Abreu SC, Antunes MA, Pelosi P, Morales MM, Rocco PR (2011) Mechanisms of cellular therapy in respiratory diseases. Intensive Care Med 37:1421–1431

    Article  PubMed  Google Scholar 

  4. Weiss DJ, Bertoncello I, Borok Z et al (2011) Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc 8:223–272

    Article  PubMed  Google Scholar 

  5. Schniedermann J, Rennecke M, Buttler K et al (2010) Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels. BMC Cell Biol 11:50

    Article  PubMed  Google Scholar 

  6. Mao M, Wang SN, Lv XJ, Wang Y, Xu JC (2010) Intravenous delivery of bone marrow-derived endothelial progenitor cells improves survival and attenuates lipopolysaccharide-induced lung injury in rats. Shock 34:196–204

    Article  PubMed  Google Scholar 

  7. Gao X, Chen W, Liang Z, Chen L (2011) Autotransplantation of circulating endothelial progenitor cells protects against lipopolysaccharide-induced acute lung injury in rabbit. Int Immunopharmacol 11:1584–1590

    Article  PubMed  CAS  Google Scholar 

  8. Badri L, Walker NM, Ohtsuka T et al (2011) Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells. Am J Respir Cell Mol Biol 45:809–816

    Article  PubMed  CAS  Google Scholar 

  9. Fujiwara A, Kobayashi H, Masuya M et al (2012) Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases. Respirology 17:693–698

    Article  PubMed  Google Scholar 

  10. Ortiz LA, Gambelli F, McBride C et al (2003) Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 100:8407–8411

    Article  PubMed  CAS  Google Scholar 

  11. Xu J, Mora A, Shim H, Stecenko A, Brigham KL, Rojas M (2007) Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Am J Respir Cell Mol Biol 37:291–299

    Article  PubMed  CAS  Google Scholar 

  12. Iyer SS, Torres-Gonzalez E, Neujahr DC et al (2010) Effect of bone marrow-derived mesenchymal stem cells on endotoxin-induced oxidation of plasma cysteine and glutathione in mice. Stem Cells Int 2010:868076

    PubMed  Google Scholar 

  13. Lee SH, Jang AS, Kim YE et al (2010) Modulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis. Respir Res 11:16

    Article  PubMed  Google Scholar 

  14. Mei SH, Haitsma JJ, Dos Santos CC et al (2010) Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med 182:1047–1057

    Article  PubMed  CAS  Google Scholar 

  15. Kim ES, Chang YS, Choi SJ et al (2011) Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice. Respir Res 12:108

    Article  PubMed  CAS  Google Scholar 

  16. Tai WL, Dong ZX, Zhang DD, Wang DH (2012) Therapeutic effect of intravenous bone marrow-derived mesenchymal stem cell transplantation on early-stage LPS-induced acute lung injury in mice. Nan Fang Yi Ke Da Xue Xue Bao 32:283–290

    PubMed  CAS  Google Scholar 

  17. Mei SH, McCarter SD, Deng Y, Parker CH, Liles WC, Stewart DJ (2007) Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med 4:e269

    Article  PubMed  Google Scholar 

  18. Aguilar S, Scotton CJ, McNulty K et al (2009) Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One 4:e8013

    Article  PubMed  Google Scholar 

  19. Araujo IM, Abreu SC, Maron-Gutierrez T et al (2010) Bone marrow-derived mononuclear cell therapy in experimental pulmonary and extrapulmonary acute lung injury. Crit Care Med 38:1733–1741

    Article  PubMed  Google Scholar 

  20. Rafii S, Lyden D (2003) Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 9:702–712

    Article  PubMed  CAS  Google Scholar 

  21. Cribbs SK, Sutcliffe DJ, Taylor WR et al (2012) Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis. Intensive Care Med 38:429–436

    Article  PubMed  Google Scholar 

  22. Lam CF, Liu YC, Hsu JK et al (2008) Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits. Anesthesiology 108:392–401

    Article  PubMed  Google Scholar 

  23. Brudecki L, Ferguson DA, Yin D, Lesage GD, McCall CE, El Gazzar M (2012) Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis. Infect Immun 80:602–611

    Article  PubMed  CAS  Google Scholar 

  24. Leung CC, Yu IT, Chen W (2012) Silicosis. Lancet 379:2008–2018

    Article  PubMed  CAS  Google Scholar 

  25. Lassance RM, Prota LF, Maron-Gutierrez T et al (2009) Intratracheal instillation of bone marrow-derived cell in an experimental model of silicosis. Respir Physiol Neurobiol 169:227–233

    Article  PubMed  Google Scholar 

  26. Maron-Gutierrez T, Castiglione RC, Xisto DG et al (2011) Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis. Eur Respir J 37:1217–1225

    Article  PubMed  CAS  Google Scholar 

  27. Huertas A, Testa U, Riccioni R et al (2010) Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI. Respir Physiol Neurobiol 170:23–31

    Article  PubMed  CAS  Google Scholar 

  28. Ishizawa K, Kubo H, Yamada M et al (2004) Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells. Biochem Biophys Res Commun 324:276–280

    Article  PubMed  CAS  Google Scholar 

  29. Murakami S, Nagaya N, Itoh T et al (2005) Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice. Am J Respir Crit Care Med 172:581–589

    Article  PubMed  Google Scholar 

  30. Ishikawa T, Aoshiba K, Yokohori N, Nagai A (2006) Macrophage colony-stimulating factor aggravates rather than regenerates emphysematous lungs in mice. Respiration 73:538–545

    Article  PubMed  CAS  Google Scholar 

  31. Adachi Y, Oyaizu H, Taketani S et al (2006) Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versa. Stem Cells 24:2071–2077

    Article  PubMed  Google Scholar 

  32. Wilson AA, Kwok LW, Hovav AH et al (2008) Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. Am J Respir Cell Mol Biol 39:133–141

    Article  PubMed  CAS  Google Scholar 

  33. Cruz FF, Antunes MA, Abreu SC et al (2012) Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model. Respir Physiol Neurobiol 182:26–36

    Article  PubMed  CAS  Google Scholar 

  34. Zhen G, Xue Z, Zhao J et al (2010) Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells. Cytotherapy 12:605–614

    Article  PubMed  CAS  Google Scholar 

  35. Schweitzer KS, Johnstone BH, Garrison J et al (2011) Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. Am J Respir Crit Care Med 183:215–225

    Article  PubMed  Google Scholar 

  36. Kim EK, Lee JH, Jeong HC et al (2012) Impaired colony-forming capacity of circulating endothelial progenitor cells in patients with emphysema. Tohoku J Exp Med 227:321–331

    Article  PubMed  Google Scholar 

  37. Allakhverdi Z, Comeau MR, Smith DE et al (2009) CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation. J Allergy Clin Immunol 123:472–478

    Article  PubMed  CAS  Google Scholar 

  38. Mehrad B, Burdick MD, Zisman DA, Keane MP, Belperio JA, Strieter RM (2007) Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun 353:104–108

    Article  PubMed  CAS  Google Scholar 

  39. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S (2003) Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 171:380–389

    PubMed  CAS  Google Scholar 

  40. Asosingh K, Swaidani S, Aronica M, Erzurum SC (2007) Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma. J Immunol 178:6482–6494

    PubMed  CAS  Google Scholar 

  41. Doyle TM, Ellis R, Park HJ, Inman MD, Sehmi R (2011) Modulating progenitor accumulation attenuates lung angiogenesis in a mouse model of asthma. Eur Respir J 38:679–687

    Article  PubMed  CAS  Google Scholar 

  42. Bonfield TL, Koloze M, Lennon DP, Zuchowski B, Yang SE, Caplan AI (2010) Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol 299:L760–L770

    Article  PubMed  CAS  Google Scholar 

  43. Abreu SC, Antunes MA, Maron-Gutierrez T et al (2011) Effects of bone marrow-derived mononuclear cells on airway and lung parenchyma remodeling in a murine model of chronic allergic inflammation. Respir Physiol Neurobiol 175:153–163

    Article  PubMed  CAS  Google Scholar 

  44. Goodwin M, Sueblinvong V, Eisenhauer P et al (2011) Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice. Stem Cells 29:1137–1148

    Article  PubMed  CAS  Google Scholar 

  45. Lee SH, Jang AS, Kwon JH, Park SK, Won JH, Park CS (2011) Mesenchymal stem cell transfer suppresses airway remodeling in a toluene diisocyanate-induced murine asthma model. Allergy Asthma Immunol Res 3:205–211

    Article  PubMed  CAS  Google Scholar 

  46. Nemeth K, Keane-Myers A, Brown JM et al (2010) Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci USA 107:5652–5657

    Article  PubMed  CAS  Google Scholar 

  47. Brown JM, Nemeth K, Kushnir-Sukhov NM, Metcalfe DD, Mezey E (2011) Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism. Clin Exp Allergy 41:526–534

    Article  PubMed  CAS  Google Scholar 

  48. Ribeiro-Paes JT, Bilaqui A, Greco OT et al (2011) Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema. Int J Chron Obstruct Pulmon Dis 6:63–71

    Article  PubMed  Google Scholar 

  49. Loivos LP, Lima MA, Szklo A et al (2010) Intrabronchial instillation of bone marrow derived mononuclear cells in silicotic patients. Am J Respir Crit Care Med 181:A1595 ((abst))

    Google Scholar 

  50. Sergio AL, Souza LPL, Lima MA et al (2011) Lung perfusion scintigraphy in silicotic patients treated with intrabronchial instillation of bone marrow derived mononuclear cells. Am J Respir Crit Care Med 183:A5212 ( (abst))

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    M. A. Antunes & P. R. M. Rocco

  2. IRCCS AOU San Martino-IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, L.go R.Benzi, 8-16132, Genoa, Italy

    P. Pelosi

Authors
  1. M. A. Antunes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. R. M. Rocco
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Pelosi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Pelosi .

Editor information

Editors and Affiliations

  1. Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Louis Vincent Prof.

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Antunes, M.A., Rocco, P.R.M., Pelosi, P. (2013). Stem Cells in Acute and Chronic Lung Injury: Building Evidence for Therapeutic Use. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2013. Annual Update in Intensive Care and Emergency Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35109-9_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-35109-9_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35108-2

  • Online ISBN: 978-3-642-35109-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation