Skip to main content
SpringerLink
Log in

Wirkstoffeliminationssysteme und Induktionschemotherapie

  • Chapter
Regionale Therapie maligner Tumoren

  • 1141 Accesses

Zusammenfassung

Seit Beginn der chemotherapeutischen Behandlung von Krebs Anfang der 1940er Jahre [1–3] wurden zahlreiche Wirkstoffe, Vorrichtungen und Methoden zur Behandlung fortgeschrittener solider Tumore entwickelt. Diese hatten eine Verbesserung der Wirkstoffzufuhr zum Ziel, wobei gleichzeitig sowohl die lokale/regionale als auch die systemische Toxizität in vertretbaren Grenzen gehalten werden sollte. Die Toxizität als dosisbeschränkender Faktor bei den meisten Chemotherapeutika ist nicht das einzige Hindernis für bessere Tumoransprechraten und klinische Ergebnisse. Die Wirkstoffzufuhr in die Tumorzellen stellt jedoch weiterhin einen der Hauptfaktoren dar, der eine komplette Remission bei fortgeschrittenen malignen Erkrankungen verhindert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Gilman A, Philips FS. Biological actions and therapeutic applications of B-chloroethyl amines and sulfides. Science. 1946;103:409–15.

    Article  Google Scholar 

  2. Jacobson LO, Spurr CL, Barron ES, et al. Nitrogen mustard therapy; studies on the effect of methyl-bis (beta-chloroethyl) amine hydrochloride on neoplastic disease and allied disorders of hemopoietic system. JAMA. 1946; 132:263–71.

    Google Scholar 

  3. Rhoads CP. Report on a cooperative study of nitrogen mustard (HN2) therapy of neoplastic disease. Trans Assoc Am Phys. 1947;60:110–7.

    Google Scholar 

  4. Adam R, Wicherts DA, de Haas RJ, Aloia T, Levi F, Paule B, et al. Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: myth or reality? J Clin Oncol. 2008;26:1635–41.

    Google Scholar 

  5. Ku Y, Fukumoto T, Tominaga M, Iwasaki T, Maeda I, Kusunoki N, et al. Single catheter technique of hepatic venous isolation and extracorporeal charcoal hemoperfusion for malignant liver tumors. Am J Surg. 1973;173:101–9.

    Google Scholar 

  6. Klopp CT, Alford TC, Bateman J, et al. Fractional intra-arterial cancer chemotherapy with methyl-bis-amine hydrochloride. A preliminary report. Ann Surg. 1950; 132:811–32.

    Article  Google Scholar 

  7. Bierman HR, Shimkin MB, Byron RL Jr, et al. The effects of intra-arterial administration of nitrogen mustard. Fifth International Cancer Congress, Paris, 1950, p. 187–8.

    Google Scholar 

  8. Sullivan RD, Norcross JW, Watkins Jr E. Chemotherapy of metastatic liver cancer by prolonged hepatic-artery infusion. N Engl J Med. 1964;270:321–7.

    Article  Google Scholar 

  9. Sullivan RD. Chemotherapy in head and neck cancer. JAMA. 1971;217:461–2.

    Google Scholar 

  10. Sullivan RD, Miller E, Sykes MP. Antimetabolite-metabolite combination cancer chemotherapy. Effects of intraarterial methotrexate-intramuscular citrovorum factor therapy in human cancer. Cancer. 1959;12:1248–62.

    Article  Google Scholar 

  11. Golomb FM. Perfusion and infusion chemotherapy of the head and neck. In: Fifth national cancer conference proceedings. Philadelphia: JB Lippincott; 1964. p. 561–72.

    Google Scholar 

  12. Krementz ET, Kokame GM. Regional chemotherapy of cancer of the head and neck. Laryngoscope. 1966;76: 880– 92.

    Google Scholar 

  13. Stephens FO. CRAB chemotherapy. Med J Aust. 1976; 2:41–6.

    Google Scholar 

  14. Ryan RF, Krementz ET, Creech O, et al. Selected perfusion of isolated viscera with chemotherapeutic agents using an extracorporeal circuit. Surg Forum. 1957;8:158–61.

    Google Scholar 

  15. Creech Jr O, Krementz ET, Ryan RF, Winblad JM. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958;148:616–32.

    Article  Google Scholar 

  16. Krementz ET. Regional perfusion: current sophistication, what next? Cancer. 1986;57:416–32.

    Article  Google Scholar 

  17. Golomb FM, Postel AH, Hall AB, et al. Chemotherapy of human cancer by regional perfusion. Report of 52 perfusions. Cancer. 1962;15:828–45.

    Article  Google Scholar 

  18. Austen WA, Monaco AP, Richardson GS, et al. Treatment of malignant pelvic tumors by extracorporeal perfusion with chemotherapeutic agents. N Engl J Med. 1959; 261:1045–52.

    Article  Google Scholar 

  19. Stehlin JS, Clark RL, White EC, et al. Regional chemotherapy for cancer: experiences with 116 perfusions. Ann Surg. 1960;151:605–19.

    Article  Google Scholar 

  20. Dedrick RL, Oldfield EH, Collins JH. Arterial drug infusion with extracorporeal removal. I. Theoretic basis with particular reference to the brain. Cancer Treat Rep. 1984; 68:373–80.

    Google Scholar 

  21. Aigner KR, Filler H, Walter H, Link KH. Drug filtration in high-dose regional chemotherapy. Contrib Oncol. 1988;29:261–80.

    Google Scholar 

  22. Muchmore JH, Krementz ET, Carter RD, et al. Treatment of abdominal malignant neoplasms using regional chemotherapy with hemofiltration. Arch Surg. 1991;126:1390–6.

    Article  Google Scholar 

  23. Eckman WW, Patlak CS, Fenstermacher JD. Critical evaluation of principles governing the advantages of intra-arterial infusions. J Pharmacokinet Biopharm. 1974; 2:257–85.

    Google Scholar 

  24. Oldfield EH, Dedrick RL, Yeager RL, et al. Reduced systemic drug exposure by combining intra-arterial chemotherapy with hemoperfusion of regional venous drainage. J Neurosurg. 1985;63:726–32.

    Google Scholar 

  25. Hande KR, Balow JE, Drake JC, Rosenberg SA, Chabner BA. Methotrexate and hemodialysis [letter]. Ann Intern Med. 1977;87:495–6.

    Article  Google Scholar 

  26. Winchester JF, Gelfand MC, Knepshield JH, Schreiner GE. Dialysis and hemoperfusion of poisons and drugs – update. Trans Am Soc Artif Intern Organs. 1977;23:762–827.

    Article  PubMed  CAS  Google Scholar 

  27. Winchester JF, Rahman A, Tilstone WJ, Bregman H, Mortensen LM, Gelfand MC, et al. Will hemoperfusion be useful for cancer chemotherapeutic drug removal? Clin Toxicol. 1980;17: 557–69.

    Article  Google Scholar 

  28. Schreiner GE. Perspectives on the hemoperfusion of drugs and toxins. Biomater Artif Cells Artif Org. 1987;15:305–21.

    Google Scholar 

  29. Forni LG, Hilton PJ. Continuous hemofiltration in the treatment of acute renal failure. N Engl J Med. 1977;336:1303–9.

    Google Scholar 

  30. Leypoldt JK, Ronco C. Optimization of high-flux, hollowfiber artificial kidneys. In: Horl WH, Koch KM, Lindsay RM, Ronco C, Winchester JF, editors. Replacement of renal function by dialysis. 5th ed. Dordrecht: Kluwer Academic; 2004. p. 95–113.

    Google Scholar 

  31. Schulman G, Himmelfarb J. Hemodialysis. In: Brenner BM, editor. The kidney. 7th ed. Philadelphia: Saunders; 2004. p. 2563–624.

    Google Scholar 

  32. Chang IJ, Fischbach BV, Sile S, Golper TA. Extracorporeal treatment of poisoning. In: Brenner BM, editor. The kidney. 7th ed. Philadelphia: Saunders; 2004. p. 2733–57.

    Google Scholar 

  33. Ronco C, Brendolan A, Bellomo R. Dialysis techniques: continuous renal replacement techniques. In: Horl WH, Koch KM, Lindsay RM, Ronco C, Winchester JF, editors. Replacement of renal function by dialysis. 5th ed. Dordrecht: Kluwer Academic; 2004. p. 699–708.

    Google Scholar 

  34. Winchester JF. Dialysis techniques: hemoperfusion. In: Horl WH, Koch KM, Lindsay RM, Ronco C, Winchester JF, editors. Replacement of renal function by dialysis. 5th ed. Dordrecht: Kluwer Academic; 2004. p. 725–38.

    Google Scholar 

  35. Kihara T, Goya N, Nakazawa H, et al. A pharmacokinetic study of arterial infusion chemotherapy for malignant diseases combined with direct hemoperfusion (DHP). Jpn J Artif Organs. 1986;15:1275–9.

    Google Scholar 

  36. Kihara T, Nakazawa H, Agushi T, Honda H. Superiority of selective bolus infusion and simultaneous rapid removal of anticancer agents by charcoal hemoperfusion in cancer treatment. Trans Am Soc Artif Intern Organs. 1988;34:581–4.

    Google Scholar 

  37. Ravikumar TS, Pizzorno G, Bodden W, et al. Percutaneous hepatic vein isolation and high-dose hepatic artery infusion chemotherapy for unresectable liver tumors. J Clin Oncol. 1994;12:2733–6.

    Google Scholar 

  38. Pinkpank JF, Libutti SK, Chang R, Wood BJ, Neewan Z, Kam AW, et al. Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies. J Clin Oncol. 2005;23:3465–74.

    Google Scholar 

  39. Ku Y, Fukumoto T, Tominaga M, Iwasaki T, Maeda I, Kusunoki N, Obara H, Sako M, et al. Single catheter technique of hepatic venous isolation and extracorporeal charcoal hemoperfusion for malignant liver tumors. Am J Surg 1973: 173:101–109.

    Google Scholar 

  40. Ku Y, Iwasaki T, Fukumoto T, Tominaga M, Muramatsu S, Kusunoki N, et al. Induction of long-term remission in advanced hepatocellular carcinoma with percutaneous isolated liver chemoperfusion. Ann Surg. 1998;227:519–26.

    Article  Google Scholar 

  41. Krementz ET, Carter RD, Sutherland CM, et al. Regional perfusion of melanoma – a 35 year experience. Ann Surg. 1994;220:520–35.

    Article  PubMed  CAS  Google Scholar 

  42. Muchmore JH, Carter RD, Krementz ET. Regional perfusion for malignant melanoma and soft tissue sarcoma: a review. Cancer Invest. 1985;3:129–43.

    Article  Google Scholar 

  43. Kroon HM, Moncrieff M, Kam PC, Thompson JF. Outcomes following isolated limb infusion for melanoma. A 14-year experience. Ann Surg Oncol. 2008;15:3003–13.

    Article  Google Scholar 

  44. Muchmore JH, Arya J. Regional chemotherapy of cancer of the pancreas. In: Markman M, editor. Current clinical oncology: regional chemotherapy: clinical research and practice. Totowa: Humana Press; 1996. p. 101–25.

    Google Scholar 

  45. Muchmore JH. Treatment of advanced pancreatic cancer with regional chemotherapy plus hemofiltration. Semin Surg Oncol. 1995;11:154–67.

    Article  Google Scholar 

  46. Aigner KR, Gailhofer S. Celiac axis infusion for locally metastasized pancreatic cancer using spherex/mitoxantron microembolization and mitomycin C/chemofiltration. Reg Cancer Treat. 1991;4:3.

    Google Scholar 

  47. Muchmore JH, Aigner KH, Beg MH. Regional chemotherapy for advanced intraabdominal and pelvic cancer. In: Cohen AM, Winawer SJ, Friedman MA, Gunderson LL, editors. Cancer of the colon, rectum, and anus. New York: McGraw-Hill; 2005. p. 881–9.

    Google Scholar 

  48. Vaupel P. Hypoxia in neoplastic tissue. Microvasc Res. 1977;13:399–408.

    Article  PubMed  CAS  Google Scholar 

  49. Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev. 1990;9:253–66.

    Article  Google Scholar 

  50. Heldin CH, Rubin K, Pietras K, et al. High interstitial fluid pressure: an obstacle in cancer therapy. Nat Rev Cancer. 2004;4:806–13.

    Article  Google Scholar 

  51. Reddy LH. Drug delivery to tumors: recent strategies. J Pharm Pharmacol. 2005;57:1231–42.

    Article  PubMed  CAS  Google Scholar 

  52. Jain RK. A new target for tumor therapy. N Engl J Med. 2009;360:2669–71.

    Article  Google Scholar 

  53. Curti BD. Physical barriers to drug delivery in tumors. In: Chabner BA, Longo DL, editors. Cancer chemotherapy and biotherapy. 2nd ed. Philadelphia: Lippincott-Raven; 1966. p. 709–19.

    Google Scholar 

  54. Rice GC, Hoy C, Schimke RT. Transient hypoxia enhances the frequency of DHFR gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci USA. 1986;83:5978– 82.

    Article  Google Scholar 

  55. Komatsu K, Miller RC, Hall EJ. The oncogenic potential of a combination of hyperthermia and chemotherapy agents. Br J Cancer. 1988;57:59–63.

    Article  PubMed  CAS  Google Scholar 

  56. Reinhold HS, van den Berg-Blok A. Enhancement of thermal damage to the microcirculation of ›sandwich‹ tumours by additional treatment. Eur J Cancer Clin Oncol. 1981;17:781– 95.

    Article  Google Scholar 

  57. Mitchell RB, Ratain MJ, Vogelzang NJ. Experimental rationale for continuous infusion chemotherapy. In: Lokich JJ, editor. Cancer chemotherapy by infusion. 2nd ed. Chicago: Precept; 1990. p. 3–34.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, 70112, New Orleans, LA, USA

    Prof. James H. Muchmore

Authors
  1. Prof. James H. Muchmore
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medias Klinikum Burghausen, Burghausen

    Karl Reinhard Aigner

  2. University of Sydney, Sydney, Australia

    Frederick O. Stephens

  3. Universitätsklinikum Frankfurt, Frankfurt

    Thomas J. Vogl

  4. Universitätsklinikum Gießen, Gießen

    Winfried Padberg

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Muchmore, J.H. (2013). Wirkstoffeliminationssysteme und Induktionschemotherapie. In: Aigner, K.R., Stephens, F.O., Vogl, T.J., Padberg, W. (eds) Regionale Therapie maligner Tumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35014-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-35014-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35013-9

  • Online ISBN: 978-3-642-35014-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation