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Bioluminescence Tomography

  • Chapter
Molecular Imaging

Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

Abstract

Among all of the modalities in molecular imaging, because of the excellent performance and cost performance, optical molecular imaging has attracted much attention over the last few years. Fluorescence and bioluminescence imaging are now commonly used for optical molecular imaging. In contrast with fluorescence imaging, there is no inherent tissue autofluorescence generated by external illumination in bioluminescence imaging, which makes it extremely sensitive. Since plane bioluminescence imaging cannot provide information about bioluminescent source distribution, bioluminescence tomography (BLT) with quantitative and localized analysis of bioluminescent source distribution has become a research hotspot. Therefore, bioluminescence tomography (BLT) has become an important instrument for revealing molecular and cellular signatures that are critically important for numerous biomedical studies. In this chapter, we focus exclusively on bioluminescence tomography.

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References

  1. Contag, C. H. & M. H. Bachmann (2002). “Advances in vivo bioluminescence imaging of gene expression”, Annual Review of Biomedical Engineering 4: 235–260. Rice, B. W., M. D. Cable & M. B. Nelson (2001). “In vivo imaging of light-emitting probes”, Journal of Biomedical Optics 6: 432–440.

    Article  PubMed  CAS  Google Scholar 

  2. Allard, M., D. Côté, L. Davidson, J. Dazai & R. M. Henkelman (2007). “Combined magnetic resonance and bioluminescence imaging of live mice”, Journal of Biomedical Optics 12(3): 034018–1–11.

    Article  PubMed  Google Scholar 

  3. Wang, G., E. A. Hoffman, G. McLennan, L. V. Wang, M. Suter & J. F. Meinel (2003). “Development of the first bioluminescence CT scanner”, Radiology 566: 229.

    Google Scholar 

  4. Cong, W. X., G. Wang, D. Kumar, Y. Liu, M. Jiang, L. V. Wang, E. A. Hoffman, G. McLennan, P. B. McCray, J. Zabner & A. Cong (2005). “Practical reconstruction method for bioluminescence tomography”, Optics Express 13: 6756–6771.

    Article  PubMed  Google Scholar 

  5. Cong W. & G. Wang (2006). “Iterative method for bioluminescence tomography based on the radiative transport equation”, Proceedings of SPIE 6318: 631826-1-7.

    Google Scholar 

  6. Wang, G., Y. Li & M. Jiang (2004). “Uniqueness theorems in bioluminescence tomography”, Medical Physics 31: 2289–2299.

    Article  PubMed  Google Scholar 

  7. Zhao, H., T. C. Doyle, O. Coquoz, F. Kalish, B. W. Rice & C. H. Contag (2005). “Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo”, Journal of Biomedical Optics 10: 041210-1-9.

    Google Scholar 

  8. Feng, J. C., K. B. Jia, C. H. Qin, G. R. Yan, S. P. Zhu, X. Zhang, J. T. Liu & J. Tian (2009). “Three-dimensional bioluminescence tomography based on Bayesian approach”, Optics Express 17(19): 16834–16848.

    Article  PubMed  CAS  Google Scholar 

  9. Zacharopoulos, A. D., P. Svenmarker, J. Axelsson, M. Schweiger, S. R Arridge & S. Andersson-Engels (2009). “A matrix-free algorithm for multiple wavelength fluorescence tomography”, Optics Express 17: 3025–3035.

    Article  PubMed  Google Scholar 

  10. Dehghani, H., S. C. Davis & B. W. Pogue (2008). “Spectrally resolved bioluminescence tomography using the reciprocity approach”, Medical Physics 35(11): 4863–4871.

    Article  PubMed  Google Scholar 

  11. Klose, A. D., V. Ntziachristos & A. H. Hielscher (2005). “The inverse source problem based on the radiative transfer equation in optical molecular imaging”, Journal of Computational Physics 202: 323–345.

    Article  Google Scholar 

  12. Gibson, A. P., J. C. Hebden & S. R. Arridge (2005). “Recent advances in diffuse optical imaging”, Physics in Medical Biology 50: R1–R43.

    Article  CAS  Google Scholar 

  13. Lü, Y. J. & A. F. Chatziioannou (2009). “A parallel adaptive finite element method for the simulation of photon migration with the radiative-transferbased model”, Communications in Numerical Methods in Engineering 25(6): 751–770.

    Article  PubMed  Google Scholar 

  14. Cong, W. X. & G. Wang (2006). “Boundary integral method for bioluminescence tomography”, Journal of Biomedical Optics Letters 1: 020503-1-020503-3.

    Google Scholar 

  15. Lü, Y., J. Tian, W. Cong, G. Wang, J. Luo, W. Yang & H. Li (2006). “A multilevel adaptive finite element algorithm for bioluminescence tomography”, Opt. Express 14: 8211–8223.

    Article  Google Scholar 

  16. Qin, C. H., J. Tian, X. Yang, K. Liu, G. R. Yan, J. C. Feng, Y. J. Lü, M. Xu (2008). “Galerkin-based meshless methods for photon transport in the biological tissue”, Optics Express 16(25):20317–20333.

    Article  PubMed  Google Scholar 

  17. Cong, W. X., K. Durairaj, L. V. Wang & G. Wang (2006). “A Born-type approximation method for bioluminescence tomography”, Medical Physics 33: 679–686.

    Article  PubMed  Google Scholar 

  18. Gu, X., Q. Zhang, L. Larcom & H. Jiang (2004). “Three-dimensional bioluminescence tomography with model-based reconstruction”, Optics Express 12: 3996–4000.

    Article  PubMed  Google Scholar 

  19. Alexandrakis, G., F. R. Rannou & A. F Chatziioannou (2005). “Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study”, Physics in Medicine and Biology 50: 4225–4241.

    Article  PubMed  Google Scholar 

  20. Chaudhari, A. J., F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry & R. M. Leahy (2005). “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging”, Physics in Medicine and Biology 50: 5421–5441.

    Article  PubMed  Google Scholar 

  21. Slavine, N. V., M. A. Lewis, E. Richer & P. P. Antich (2006). “Iterative reconstruction method for light emitting sources based on the diffusion equation”, Medical Physics 33: 61–68.

    Article  PubMed  Google Scholar 

  22. Wang, G., W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan & M. Henry (2006). “In vivo mouse studies with bioluminescence tomography”, Optics Express 14: 7801–7809.

    Article  PubMed  Google Scholar 

  23. Wang, G., H. Shen, W. Cong, S. Zhao & G. Wei (2006). “Temperaturemodulated bioluminescence tomography”, Optics Express 14: 7852–7871.

    Article  PubMed  Google Scholar 

  24. Jiang, M., T. Zhou, J. Cheng, W. Cong & G. Wang (2007). “Image reconstruction for bioluminescence tomography from partial measurement”, Optics Express 15: 11095–11116.

    Article  PubMed  Google Scholar 

  25. Lü, Y., J. Tian, W. Cong, G. Wang, W. Yang, C. Qin & M. Xu (2007). “Spectrally resolved bioluminescence tomography with adaptive finite element: methodology and simulation”, Physics in Medical Biology 52: 4497–4512.

    Article  Google Scholar 

  26. Zhang, Q., L. Yin, Y. Tan, Z. Yuan & H. Jiang (2008). “Quantitative bioluminescence tomography guided by diffuse optical tomography”, Opt. Express 16: 1481–1486.

    Article  PubMed  Google Scholar 

  27. Feng, J., K. Jia, G. Yan, S. Zhu, C. Qin, Y. Lü & J. Tian (2008). “An optimal permissible source region strategy for multispectral bioluminescence tomography”, Optics Express 16: 15640–15654.

    Article  PubMed  Google Scholar 

  28. Lü, Y. J., X. Q. Zhang, A. Douraghy, D. Stout, J. Tian, T. F. Chan & A. F. Chatziioannou (2009). “Source reconstruction for spectrally-resolved bioluminescence tomography with sparse a priori information”, Optics Express 17: 8062–8080.

    Article  PubMed  Google Scholar 

  29. Lü, Y., J. J. Tian, W. X. Cong & G. Wang (2007). “Experimental study on bioluminescence tomography with multi-modality imaging fusion”, International Journal of Biomedical Imaging 2007: 86741.

    Article  Google Scholar 

  30. Ahn, S. A. J. Chaudhari, F. Darvas, C. A. Bouman & R. M Leahy (2008). “Fast iterative image reconstruction methods for fully 3D multispectral bioluminescence tomography”, Phys. Med. Biol. 53 3921–3942.

    Article  PubMed  Google Scholar 

  31. Ishimaru, A. (1997). Wave Propagation and Scattering in Random Media. IEEE Press.

    Google Scholar 

  32. Arridgey, S. R. & J. C. Hebdenz (1997). “Optical imaging in medicine II: modelling and reconstruction”, Physics in Medical Biology 42: 841–853.

    Article  Google Scholar 

  33. Wang, L. V. & H. I. Wu (2007). Biomedical Optics: Principles and Imaging. Hoboken, Wiley-InterScience.

    Google Scholar 

  34. Schweiger, M., S. R. Arridge, M. Hiraoka & D. T. Delpy (1995). “The finite element method for the propagation of light in scattering media: boundary and source conditions”, Medical Physics 22(11): 1779–1792.

    Article  PubMed  CAS  Google Scholar 

  35. Zhao, H., T. C. Doyle, O. Coquoz, F. Kalish, B. W. Rice & C. H. Contag (2005). “Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo”, Journal of Biomedical Optics 10: 041210.

    Article  Google Scholar 

  36. Cong, A. X. & G. Wang (2006). “Multispectral bioluminescence tomography: methodology and simulation”, International Journal of Biomedical Imaging 2006: 1–7.

    Article  Google Scholar 

  37. Wang, G., H. O. Shen, K. Durairaj, X. Qian & W. X. Cong (2006). “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data”, International Journal of Biomedical Imaging (2006): 58601.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China

    Jie Tian, Xin Yang, Chenghu Qin & Kai Liu

Authors
  1. Jie Tian
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  2. Xin Yang
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  3. Chenghu Qin
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  4. Kai Liu
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© 2013 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg

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Tian, J., Yang, X., Qin, C., Liu, K. (2013). Bioluminescence Tomography. In: Molecular Imaging. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34303-2_5

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