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Treatment Status Predicts Differential Prefrontal Cortical Responses to Alcohol and Natural Reinforcer Cues among Alcohol Dependent Individuals

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Advances in Brain Inspired Cognitive Systems (BICS 2012)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 7366))

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Abstract

This study used functional near-infrared spectroscopy (fNIRs) to test the hypothesis that non-treatment seeking alcohol-dependent participants (NTSA) would show greater response in dorsolateral prefrontal cortex (DLPFC) to alcohol cues than recovering alcoholics (RA; sober 90-180 days) or social drinkers. Opposite predictions were made for responses to natural reward cues. NTSA (n=4), RA (n=6), and social drinkers (n=4) were exposed to alcohol and natural reward cues while being monitored with fNIRs. Results confirmed enhanced responses to alcohol cues among NTSA vs. RA in right middle frontal gyrus. The opposite effect (RA>NTSA) was found in response to natural reward cues. Neural responses to alcohol and natural reward cues were negatively correlated in right DLPFC. Real-time craving ratings were positively correlated with greater neural response to alcohol cues. Differential responses to drug and natural reward cues suggest that a psychological mechanism related to treatment status may modulate drug cue responses in DLPFC.

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Author information

Authors and Affiliations

  1. Penn State Hershey Medical Center and Penn State College of Medicine, Hershey, PA, 17003, USA

    Scott C. Bunce

  2. School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, PA, 19104, USA

    Scott C. Bunce, Kurtulus Izzetoglu, Meltem Izzetoglu, Hasan Ayaz, Kambiz Pourrezaei & Banu Onaral

  3. Cognitive Neuroengineering and Quantitative Experimental Research, (CONQUER) Collaborative, Drexel University, Philadelphia, PA, 19104, USA

    Scott C. Bunce, Kurtulus Izzetoglu, Meltem Izzetoglu, Hasan Ayaz, Kambiz Pourrezaei & Banu Onaral

Authors
  1. Scott C. Bunce
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  2. Kurtulus Izzetoglu
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  3. Meltem Izzetoglu
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  4. Hasan Ayaz
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  5. Kambiz Pourrezaei
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  6. Banu Onaral
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Editor information

Editors and Affiliations

  1. College of Information Science and Engineering, Northeastern University, 110004, Shenyang, P.R. China

    Huaguang Zhang

  2. Dept. of Computing Science and Mathematics, University of Stirling, FK9 4LA, Stirling, Scotland, UK

    Amir Hussain

  3. Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China

    Derong Liu

  4. Northeastern University, School of Information Science and Engineering, 110004, Shenyang, Liaoning, People’s Republic of China

    Zhanshan Wang

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© 2012 Springer-Verlag Berlin Heidelberg

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Bunce, S.C., Izzetoglu, K., Izzetoglu, M., Ayaz, H., Pourrezaei, K., Onaral, B. (2012). Treatment Status Predicts Differential Prefrontal Cortical Responses to Alcohol and Natural Reinforcer Cues among Alcohol Dependent Individuals. In: Zhang, H., Hussain, A., Liu, D., Wang, Z. (eds) Advances in Brain Inspired Cognitive Systems. BICS 2012. Lecture Notes in Computer Science(), vol 7366. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31561-9_20

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  • DOI: https://doi.org/10.1007/978-3-642-31561-9_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-31560-2

  • Online ISBN: 978-3-642-31561-9

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