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Neurotransmitter Release During Deep Brain Stimulation

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Deep Brain Stimulation

Abstract

Deep brain stimulation (DBS) is currently under investigation for treatment of a number of psychiatric indications, including obsessive–compulsive disorder, treatment-resistant depression, and Tourette’s syndrome. Despite its clinical efficacy, the mechanism of action of DBS is incompletely understood. Contrary to the previously proposed mechanism of local inhibition of neural elements at the stimulation site, recent studies have argued that DBS may also cause excitation of efferent target neurons and subsequent changes in neural network activity and neurotransmitter release at various nodes within the neural network. However, the necessary link between symptom change and a corresponding change in neurotransmitters has yet to be firmly established and will be essential to advance our understanding of psychiatric neurobiology. In this chapter, we briefly review the growing scientific evidence in regard to neurotransmitter release as a possible mechanism of action of DBS and the potential impact on neuropsychiatric applications.

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Authors and Affiliations

  1. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA

    Osama A. Abulseoud

  2. Mayo Graduate School, Rochester, MN, USA

    Emily J. Knight

  3. Department of Neurosurgery and Physiology, Mayo Clinic, Rochester, MN, USA

    Kendall H. Lee

  4. Neuroengineering Laboratory, Mayo Clinic, Rochester, MN, USA

    Kendall H. Lee

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  1. Osama A. Abulseoud
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  2. Emily J. Knight
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  3. Kendall H. Lee
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Correspondence to Kendall H. Lee .

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Editors and Affiliations

  1. , Department of Psychiatry, Academic Medical Center, University of A, PO Box 75867, Amsterdam, 1070 AW, Netherlands

    Damiaan Denys

  2. , Neuromodulation and Behaviour, Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam, 1105 BA, Netherlands

    Matthijs Feenstra

  3. , Department of Neurosurger, Academic Medical Center, University of A, Meibergdreef 9, Amsterdam, 1070 AW, Netherlands

    Rick Schuurman

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Abulseoud, O.A., Knight, E.J., Lee, K.H. (2012). Neurotransmitter Release During Deep Brain Stimulation. In: Denys, D., Feenstra, M., Schuurman, R. (eds) Deep Brain Stimulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30991-5_18

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