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Deep Brain Stimulation in Tourette Syndrome

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Deep Brain Stimulation

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Abstract

In 1999 deep brain stimulation was introduced as a new therapeutic option for patients with intractable Tourette syndrome. Tourette syndrome is a neurodegenerative disorder characterized by tics and associated behavioural disorders, with typical onset in early childhood. In most patients, the symptoms decrease spontaneously when adulthood is reached, or can be treated with behavioural therapy or medication. Only a small proportion of patients are candidates for surgical treatment. About 70–80 Tourette syndrome patients having received deep brain stimulation have been described in the literature. A diversity of targets have been used, mainly located at the level of the medial part of the thalamus, in the globus pallidus interna (anteromedial limbic and posteroventrolateral motor part), the globus pallidus externa, and the internal capsule/nucleus accumbens. Because of the small number of patients, there is a strong need for multicentre, double-blind trials with standard protocols.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands

    L. Ackermans & V. Visser-Vandewalle

  2. Maastricht Institute for Neuromodulative Development (MIND), Maastricht, The Netherlands

    L. Ackermans & V. Visser-Vandewalle

  3. Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany

    I. Neuner

  4. Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

    J. Kuhn

Authors
  1. L. Ackermans
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  2. I. Neuner
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  3. J. Kuhn
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  4. V. Visser-Vandewalle
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Corresponding author

Correspondence to V. Visser-Vandewalle .

Editor information

Editors and Affiliations

  1. , Department of Psychiatry, Academic Medical Center, University of A, PO Box 75867, Amsterdam, 1070 AW, Netherlands

    Damiaan Denys

  2. , Neuromodulation and Behaviour, Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam, 1105 BA, Netherlands

    Matthijs Feenstra

  3. , Department of Neurosurger, Academic Medical Center, University of A, Meibergdreef 9, Amsterdam, 1070 AW, Netherlands

    Rick Schuurman

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Ackermans, L., Neuner, I., Kuhn, J., Visser-Vandewalle, V. (2012). Deep Brain Stimulation in Tourette Syndrome. In: Denys, D., Feenstra, M., Schuurman, R. (eds) Deep Brain Stimulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30991-5_12

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