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Release of Outer Membrane Vesicles: Is it a Novel Secretion Mechanism?

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Outer Membrane Vesicles of Bacteria

Part of the book series: SpringerBriefs in Microbiology ((BRIEFSMICROBIOL))

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Abstract

From a comparison of the role of membranes in eukaryotic cells in the secretion of viruses and other materials it was originally proposed in 1967 that the formation and release of outer membrane vesicles (OMVs) from a Gram-negative bacterial cell represented a novel secretion mechanism of these bacteria. Subsequent experimental studies including genetic analysis supported and established the original idea. While discussing these aspects it is now proposed that the formation and release of OMVs represented the seventh secretion mechanism of Gram-negative bacteria in general.

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References

  • Bennett HS (1956) The concepts of membrane flow and membrane vesiculation as mechanisms for active transport and ion pumping. J Biophys Biochem Cytol 2:99–103

    Article  PubMed  CAS  Google Scholar 

  • Binet R, Wandersman C (1995) Protein secretion by hybrid bacterial ABC-transporters: specific functions of the membrane ATPase and the membrane fusion protein. EMBO J 14:2298–2306

    PubMed  CAS  Google Scholar 

  • Cascales E, Christie PJ (2003) The versatile bacterial type IV secretion systems. Nat Rev Microbiol 1:137–149

    Article  PubMed  CAS  Google Scholar 

  • Chatterjee SN, Das J (1966) Secretory activity of Vibrio cholerae as evidenced by electron microscopy. In: Uyeda R (ed) Electron microscopy. Maruzen Co. Ltd, Tokyo

    Google Scholar 

  • Chatterjee SN, Das J (1967) Electron microscopic observations on the excretion of cell-wall material by Vibrio cholerae. J Gen Microbiol 49:1–11

    Article  PubMed  CAS  Google Scholar 

  • Desvaux M, Parham NJ, Henderson IR (2004) The autotransporter secretion system. Res Microbiol 155:53–60

    Article  PubMed  CAS  Google Scholar 

  • Epstein MA (1962) Functional aspects of the structure of some animal viruses. Br Med Bull 18:183–186

    PubMed  CAS  Google Scholar 

  • Galan JE, Collmer A (1999) Type III secretion machines: bacterial devices for protein delivery into host cells. Science 284:1322–1328

    Article  PubMed  CAS  Google Scholar 

  • Kostakioti M, Newman CL, Thanassi DG, Stathopoulos C (2005) Mechanisms of protein export across the bacterial outer membrane. J Bacteriol 187:4306–4314

    Article  PubMed  CAS  Google Scholar 

  • Kuehn MJ, Kesty NC (2005) Bacterial outer membrane vesicles and the host-pathogen interaction. Genes Dev 19:2645–2655

    Article  PubMed  CAS  Google Scholar 

  • Kulp A, Kuehn MJ (2010) Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol 64:163–184

    Article  PubMed  CAS  Google Scholar 

  • Kurosumi K (1962) Some morphological aspects of the secretory activities of various glandular cells. In: Breese SS (ed) Electron microscopy. Academic Press, London

    Google Scholar 

  • Lee EY, Choi DS, Kim KP, Gho YS (2008) Proteomics in Gram-negative bacterial outer membrane vesicles. Mass Spectrom Rev 27:535–555

    Article  PubMed  CAS  Google Scholar 

  • Lever JD (1961) Electron microscopy in anatomy. Arnold, London

    Google Scholar 

  • McBroom AJ, Kuehn MJ (2007) Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. Mol Microbiol 63:545–558

    Article  PubMed  CAS  Google Scholar 

  • McBroom AJ, Johnson AP, Vemulapalli S, Kuehn MJ (2006) Outer membrane vesicle production by Escherichia coli is independent of membrane instability. J Bacteriol 188:5385–5392

    Article  PubMed  CAS  Google Scholar 

  • Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M et al (2006) A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312:1526–1530

    Article  PubMed  CAS  Google Scholar 

  • Palade GE (1953) Fine structure of blood capillaries. J Appl Physiol 24:1424–1436

    Google Scholar 

  • Palade GE (1961) The secretory process of the pancreatic cell. In: Boyd JD, Johnson FR, Lever JD (eds) Électron Microscopy in Anatomy. Arnold, London

    Google Scholar 

  • Pilzer D, Gasser O, Moskovich O, Schifferli JA, Fishelson Z (2005) Emission of membrane vesicles: roles in complement resistance, immunity and cancer. Springer Semin Immunopathol 27:375–387

    Article  PubMed  CAS  Google Scholar 

  • Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D et al (2006) Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A 103:1528–1533

    Article  PubMed  CAS  Google Scholar 

  • Voulhoux R, Ball G, Ize B, Vasil ML, Lazdunski A, Wu LF, Filloux A (2001) Involvement of the twin-arginine translocation system in protein secretion via the type II pathway. EMBO J 20:6735–6741

    Article  PubMed  CAS  Google Scholar 

  • Wai SN, Lindmark B, Soderblom T, Takade A, Westermark M et al (2003) Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin. Cell 115:25–35

    Article  PubMed  CAS  Google Scholar 

Download references

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Correspondence to S. N. Chatterjee .

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Chatterjee, S.N., Chaudhuri, K. (2012). Release of Outer Membrane Vesicles: Is it a Novel Secretion Mechanism?. In: Outer Membrane Vesicles of Bacteria. SpringerBriefs in Microbiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30526-9_8

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