Abstract
This thesis introduces a novel coarse-grained model of DNA which is specifically designed to capture the structural, mechanical and thermodynamic properties associated with single-stranded and duplex DNA, and the transition between the two. The model has been shown to give a physically reasonable description of a range of DNA properties, and has been applied to two nanotechnological systems (DNA tweezers and a two-footed DNA walker). These studies represent the first investigations into dynamic DNA devices using a coarse-grained model.
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Ouldridge, T.E. (2012). Conclusions. In: Coarse-Grained Modelling of DNA and DNA Self-Assembly. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30517-7_9
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DOI: https://doi.org/10.1007/978-3-642-30517-7_9
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Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-642-30517-7
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