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Neuropharmakologische funktionelle Bildgebung

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Funktionelle MRT in Psychiatrie und Neurologie

Zusammenfassung

In den letzten Jahren ist die Anzahl von fMRT-Studien, die die neuralen Effekte von Psychopharmaka untersuchen, enorm gestiegen. Das Kapitel erklärt Sinn und Nutzen solcher pharmakologischer fMRT-Studien und gibt einen Überblick über die wichtigsten Arbeiten.

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Literatur

  • Achard S, Bullmore E (2007) Efficiency and cost of economical brain functional networks. PLoS Comput Biol 3: e17

    Article  PubMed  Google Scholar 

  • Bentley P, Driver J, Dolan RJ (2008) Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer‘s disease and health. Brain 131: 409–424

    Article  PubMed  Google Scholar 

  • Bentley P, Driver J, Dolan RJ (2011) Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging. Prog Neurobiol 94: 360–388

    Article  PubMed  CAS  Google Scholar 

  • Bloom AS, Hoffmann RG, Fuller SA, Pankiewicz J, Harsch HH, Stein EA (1999) Determination of drug-induced changes in functional MRI signal using a pharmacokinetic model. Hum Brain Mapp 8: 235–244

    Article  PubMed  CAS  Google Scholar 

  • Bullmore E, Sporns O (2009) Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10: 186–198

    Article  PubMed  CAS  Google Scholar 

  • Bullmore E, Suckling J, Zelaya F, Long C, Honey G, Reed L, Routledge C, Ng V, Fletcher P, Brown J, Williams SC (2003) Practice and difficulty evoke anatomically and pharmacologically dissociable brain activation dynamics. Cereb Cortex 13: 144–154

    Article  PubMed  Google Scholar 

  • Chamberlain SR, Hampshire A, Müller U, Rubia K, Del CN, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009) Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study. Biol Psychiatry 65: 550–555

    Article  PubMed  CAS  Google Scholar 

  • Cools R, Calder AJ, Lawrence AD, Clark L, Bullmore E, Robbins TW (2005) Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces. Psychopharmacology (Berl) 180: 670–679

    Article  CAS  Google Scholar 

  • Coull JT, Nobre AC, Frith CD (2001) The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting. Cereb Cortex 11: 73–84

    Article  PubMed  CAS  Google Scholar 

  • Coull JT, Jones M, Egan T, Frith CD, Maze M (2004) Noradrenergic a2 attentional effects vary with arousal level: modulation of the thalamic pulvinar in healthy humans. Neuroimage 22: 315–322

    Article  PubMed  Google Scholar 

  • Di Simplicio M, Norbury R, Harmer CJ (2012) Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression. Mol Psychiatry 17: 503–510

    Article  PubMed  Google Scholar 

  • Furey ML, Pietrini P, Haxby JV (2000) Cholinergic enhancement and increased selectivity of perceptual processing during working memory. Science 290: 2315–2319

    Article  PubMed  CAS  Google Scholar 

  • Giessing C, Fink GR, Rosler F, Thiel CM (2007) fMRI data predict individual differences of behavioral effects of nicotine: a partial least square analysis. J Cogn Neurosci 19: 658–670

    Article  PubMed  CAS  Google Scholar 

  • Goekoop R, Scheltens P, Barkhof F, Rombouts SA (2006) Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation – a pharmacological fMRI study. Brain 129: 141–157

    Article  PubMed  Google Scholar 

  • Graf H, Abler B, Freudenmann R, Beschoner P, Schaeffeler E, Spitzer M, Schwab M, Gron G (2011) Neural correlates of error monitoring modulated by atomoxetine in healthy volunteers. Biol Psychiatry 69: 890–897

    Article  PubMed  CAS  Google Scholar 

  • Grefkes C, Wang LE, Eickhoff SB, Fink GR (2009) Noradrenergic Modulation of Cortical Networks Engaged in Visuomotor Processing. Cereb Cortex 20: 783–797

    Article  PubMed  Google Scholar 

  • Grön G, Brandenburg I, Wunderlich AP, Riepe MW (2006) Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis. Neurobiol. Aging 27: 78–87

    Google Scholar 

  • Hahn B, Ross TJ, Yang Y, Kim I, Huestis MA, Stein EA (2007) Nicotine enhances visuospatial attention by deactivating areas of the resting brain default network. J Neurosci 27: 3477–3489

    Article  PubMed  CAS  Google Scholar 

  • Jocham G, Klein TA, Ullsperger M (2011) Dopamine-mediated reinforcement learning signals in the striatum and ventromedial prefrontal cortex underlie value-based choices. J Neurosci 31: 1606–1613

    Article  PubMed  CAS  Google Scholar 

  • Kelly C, de Zubicaray G, Di Martino A, Copland DA, Reiss PT, Klein DF, Castellanos FX, Milham MP, McMahon K (2009) L-dopa modulates functional connectivity in striatal cognitive and motor networks: a double-blind placebo-controlled study. J Neurosci 29: 7364–7378

    Article  PubMed  CAS  Google Scholar 

  • Kukolja J, Schlapfer TE, Keysers C, Klingmuller D, Maier W, Fink GR, Hurlemann R (2008) Modeling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactions. J Neurosci 28: 12868–12876

    Article  PubMed  CAS  Google Scholar 

  • Kukolja J, Thiel CM, Fink GR (2009) Cholinergic stimulation enhances neural activity associated with encoding but reduces neural activity associated with retrieval in humans. J Neurosci 29: 8119–8128

    Article  PubMed  CAS  Google Scholar 

  • Leslie RA, James MF (2000) Pharmacological magnetic resonance imaging: a new application for functional MRI. Trends Pharmacol Sci 21: 314–318

    Article  PubMed  CAS  Google Scholar 

  • Loubinoux I, Pariente J, Boulanouar K, Carel C, Manelfe C, Rascol O, Celsis P, Chollet F (2002) A single dose of the serotonin neurotransmission agonist paroxetine enhances motor output: doubleblind, plazebo-controlled, fMRI study in healthy subjects. Neuro- Image 15: 26–36

    PubMed  Google Scholar 

  • Mattay VS, Callicott JH, Bertolino A, Heaton I, Frank JA, Coppola R, Berman KF, Goldberg TE, Weinberger DR (2000) Effects of dextroamphetamine on cognitive performance and cortical activation. NeuroImage 12: 268–275

    Article  PubMed  CAS  Google Scholar 

  • Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, Kolachana B, Callicott JH, Weinberger DR (2003) Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 100: 6186–6191

    Article  PubMed  CAS  Google Scholar 

  • McCabe C, Mishor Z (2011) Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers. Neuroimage. 57: 1317–1323

    Article  PubMed  CAS  Google Scholar 

  • Morcom AM, Bullmore ET, Huppert FA, Lennox B, Praseedom A, Linnington H, Fletcher PC (2009) Memory Encoding and Dopamine in the Aging Brain: A Psychopharmacological Neuroimaging Study. Cereb Cortex 20: 743–757

    Article  PubMed  Google Scholar 

  • Murphy SE, Norbury R, O‘Sullivan U, Cowen PJ, Harmer CJ (2009) Effect of a single dose of citalopram on amygdala response to emotional faces. Br J Psychiatry 194: 535–540

    Article  PubMed  Google Scholar 

  • Newhouse PA, Potter AS, Dumas JA, Thiel CM (2011) Functional brain imaging of nicotinic effects on higher cognitive processes. Biochem Pharmacol 82: 943–951

    Article  PubMed  CAS  Google Scholar 

  • Northoff G, Witzel T, Richter A, Gessner M, Schlagenhauf F, Fell J, Baumgart F, Kaulisch T, Tempelmann C, Heinzel A, Kotter R, Hagner T, Bargel B, Hinrichs H, Bogerts B, Scheich H, Heinze HJ (2002) GABAergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with Plazebo and lorazepam. J Cogn Neurosci 14: 348–370

    Article  PubMed  Google Scholar 

  • Onur OA, Walter H, Schlaepfer TE, Rehme AK, Schmidt C, Keysers C, Maier W, Hurlemann R (2009) Noradrenergic enhancement of amygdala responses to fear. Soc Cogn Affect Neurosci 4: 119–126

    Article  PubMed  Google Scholar 

  • Pariente J, Loubinoux I, Carel C, Albucher JF, Leger A, Manelfe C, Rascol O, Chollet F (2001) Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol 50: 718–729

    Article  PubMed  CAS  Google Scholar 

  • Pessiglione M, Seymour B, Flandin G, Dolan RJ, Frith CD (2006) Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 442: 1042–1045

    Article  PubMed  CAS  Google Scholar 

  • Rogers RD (2011) The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. Neuropsychopharm 36: 114–132

    Article  CAS  Google Scholar 

  • Schunck T, Mathis A, Erb G, Namer IJ, Demazieres A, Luthringer R (2010) Effects of lorazepam on brain activity pattern during an anxiety symptom provocation challenge. J Psychopharmacol 24: 701–708

    Article  PubMed  CAS  Google Scholar 

  • Sperling R, Greve D, Dale A, Killiany R, Holmes J, Rosas HD, Cocchiarella A, Firth P, Rosen B, Lake S, Lange N, Routledge C, Albert M (2002 Functional MRI detection of pharmacologically induced memory impairment. Proc Natl Acad Sci USA 99: 455–460

    Article  PubMed  CAS  Google Scholar 

  • Stein EA, Pankiewicz J, Harsch HH, Cho JK, Fuller SA, Hoffmann RG, Hawkins M, Rao SM, Bandettini PA, Bloom AS (1998) Nicotine-induced limbic cortical activation in the human brain: a functional MRI study. Am J Psychiatry 155: 1009–1015

    PubMed  CAS  Google Scholar 

  • Strange BA, Dolan RJ (2004) Beta-adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses. Proc Natl Acad Sci USA 101: 11454–11458

    Article  PubMed  CAS  Google Scholar 

  • Tanabe J, Nyberg E, Martin LF, Martin J, Cordes D, Kronberg E, Tregellas JR (2011) Nicotine effects on default mode network during resting state. Psychopharmacology (Berl) 216: 287–295

    Article  CAS  Google Scholar 

  • Tardy J, Pariente J, Leger A, Dechaumont-Palacin S, Gerdelat A, Guiraud V, Conchou F, Albucher JF, Marque P, Franceries X, Cognard C, Rascol O, Chollet F, Loubinoux I (2006) Methylphenidate modulates cerebral post-stroke reorganization. Neuroimage 33: 913–922

    Article  PubMed  Google Scholar 

  • Thiel CM, Fink GR (2008) Effects of the cholinergic agonist nicotine on reorienting of visual spatial attention and top-down attentional control. Neurosci 152: 381–390

    Article  CAS  Google Scholar 

  • Thiel CM, Henson RN, Morris JS, Friston KJ, Dolan RJ (2001) Pharmacological modulation of behavioural and neuronal correlates of repetition priming. J Neurosci 21: 6846–6852

    PubMed  CAS  Google Scholar 

  • Thiel CM, Bentley P, Dolan RJ (2002a) Effects of cholinergic enhancement on conditioning-related responses in human auditory cortex. Eur J Neurosci 16:2199–2206

    Article  CAS  Google Scholar 

  • Thiel CM, Friston KJ, Dolan RJ (2002b) Cholinergic modulation of experience-dependent plasticity in human auditory cortex. Neuron 35: 567–574

    Article  CAS  Google Scholar 

  • Thiel CM, Henson RN, Dolan RJ (2002c) Scopolamine but not lorazepam modulates face repetition priming: a psychopharmacological fMRI study. Neuropsychopharmacol 27: 282–292

    Article  CAS  Google Scholar 

  • Thiel CM, Zilles K, Fink GR (2005) Nicotine modulates reorienting of visuospatial attention and neural activity in parietal cortex. Neuropsychopharmacol 30: 810–820

    CAS  Google Scholar 

  • Vossel S, Thiel CM, Fink GR (2008) Behavioral and neural effects of nicotine on visuospatial attentional reorienting in non-smoking subjects. Neuropsychopharm 33: 731–738

    Article  CAS  Google Scholar 

  • Wang LE, Fink GR, Diekhoff S, Rehme AK, Eickhoff SB, Grefkes C (2011) Noradrenergic enhancement improves motor network connectivity in stroke patients. Ann Neurol 69: 375–388

    Article  PubMed  Google Scholar 

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Thiel, C., Fink, G.R. (2013). Neuropharmakologische funktionelle Bildgebung. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29800-4_12

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  • DOI: https://doi.org/10.1007/978-3-642-29800-4_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29799-1

  • Online ISBN: 978-3-642-29800-4

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