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tRNA Biogenesis and Processing

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RNA Metabolism in Trypanosomes

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 28))

Abstract

tRNAs are essential in all domains of life; this becomes especially important in trypanosomatids, where for all purposes the same set of tRNAs are utilized for cytoplasmic and mitochondrial protein synthesis. What makes the system special is that although tRNA biogenesis starts in the nucleus, the resulting products will satisfy translational requirements in two very different compartments. The balance between intracellular tRNA transport and post-transcriptional modifications may modulate tRNA function in gene expression. This chapter will summarize what is currently known about various processes that a tRNA must undergo in a trypanosomatid cell to become fully functional. Whenever possible, we will highlight both commonalities and differences with other systems, while emphasizing open questions that may lead to new and surprising discoveries in this group of evolutionarily divergent organisms.

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Authors and Affiliations

  1. Department of Microbiology, The Ohio State Center for RNA Biology, The Ohio State University, Columbus, OH, 43210, USA

    Jessica L. Spears, Mary Anne T. Rubio, Paul J. Sample & Juan D. Alfonzo

  2. Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, 43210, USA

    Juan D. Alfonzo

Authors
  1. Jessica L. Spears
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  2. Mary Anne T. Rubio
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  3. Paul J. Sample
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  4. Juan D. Alfonzo
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Correspondence to Juan D. Alfonzo .

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  1. , Department of Biology and Chemistry, Justus Liebig University of Giessen, Heinrich-Buff-Ring 58, Giessen, 35392, Germany

    Albrecht Bindereif

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Spears, J.L., Rubio, M.A.T., Sample, P.J., Alfonzo, J.D. (2012). tRNA Biogenesis and Processing. In: Bindereif, A. (eds) RNA Metabolism in Trypanosomes. Nucleic Acids and Molecular Biology, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28687-2_5

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