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Intensity Modulated Radiotherapy for Prostate Cancer

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Management of Prostate Cancer

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Abstract

External beam irradiation is a common and standard treatment for prostate cancer. Intensity modulated radiotherapyv (IMRT) is a technique of irradiation which allows to generate concave isodoses and then to reduce the dose delivered to organs at risk of toxicities. In prostate cancer, IMRT reduces the rates of acute and late rectal and urinary toxicities. Therefore, IMRT appears as an optimal technique to escalate the dose of irradiation without causing increased toxicities. It could make easier the development of new approaches of irradiation of prostate cancers such as hypofractionated irradiation or stereotactic irradiation. The preservation of healthy tissues in IMRT could be improved by combination with the progress in imaging (fusion CT/MRI) and a systematic association with a daily repositioning using the image-guided radiotherapy (IGRT).

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References

  • Acher P, Puttagunta S, Rhode K et al (2010) An analysis of intraoperative versus post-operative dosimetry with CT, CT-MRI fusion and XMR for the evaluation of permanent prostate brachytherapy implants. Radiother Oncol 96:166–171

    Article  PubMed  Google Scholar 

  • Akimoto T, Muramatsu H, Takahashi M et al (2004) Rectal bleeding after hypofractionated radiotherapy for prostate cancer: correlation between clinical and dosimetric parameters and the incidence of grade 2 or worse rectal bleeding. Int J Radiat Oncol Biol Phys 60(4):1033–1039

    Article  PubMed  Google Scholar 

  • Alicikus ZA, Yamada Y, Zhang Z et al (2011) Ten-year outcomes of high-dose, intensity-modulated radiotherapy for localized prostate cancer. Cancer 117(7):1429–1437

    Article  PubMed  Google Scholar 

  • Arcangeli G, Saracino B, Gomellini S et al (2010) A prospective phase III randomized trial of hypofractionation versus conventional fractionation in patients with high-risk prostate cancer. Int J Radiat Oncol Biol Phys 78(1):11–18

    Article  PubMed  Google Scholar 

  • Ashman JB, Zelefsky MJ, Hunt MS et al (2005) Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 63(3):765–771

    Article  PubMed  Google Scholar 

  • Azria D, Aillieres N, Llacer Moscardo C et al (2009) Conformal intensity modulated radiation therapy for localized prostate cancer: toward a new standard. Cancer Radiother 13:409–415

    Article  PubMed  CAS  Google Scholar 

  • Balter JM, Sandler HM, Lam K et al (1995a) Measurement of prostate movement over the course of routine radiotherapy using implanted markers. Int J Radiat Oncol Biol Phys 31:113–118

    Article  PubMed  CAS  Google Scholar 

  • Balter JM, Lam KL, Sandler HM et al (1995b) Automated localization of the prostate at the time of treatment using implanted radiopaque markers: technical feasibility. Int J Radiat Oncol Biol Phys 33:1281–1286

    Article  PubMed  CAS  Google Scholar 

  • Barney BM, Lee RJ, Handrahan D, Welsh KT et al (2011) Image-guided radiotherapy (IGRT) for prostate cancer comparing kV imaging of fiducial markers with cone-beam computed tomography (CBCT). Int J Radiat Oncol Biol Phys 80:301–305

    Article  PubMed  Google Scholar 

  • Beckendorf V, Guerif S, Le Prisé E et al (2011) 70 Gy versus 80 Gy in localized prostate cancer: 5-year results of GETUG 06 randomized trial. Int J Radiat Oncol Biol Phys 80(4):1056–1063

    Article  PubMed  Google Scholar 

  • Boda-Heggemann J, Kohler FM, Kupper B et al (2008) Accuracy of ultrasound- based (BAT) prostate-repositioning: a three dimensional on-line fiducial-based assessment with cone-beam computed tomography. Int J Radiat Oncol Biol Phys 70:1247–1255

    Article  PubMed  Google Scholar 

  • Boike TP, Lotan Y, Cho LC et al (2011) Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate-risk prostate cancer. J Clin Oncol 29(15):2020–2026

    Article  PubMed  Google Scholar 

  • Brenner DJ, Hall EJ (1999) Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 43:1095–1101

    Article  PubMed  CAS  Google Scholar 

  • Brenner DJ, Martinez AA, Edmundson GK (2002) Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys 52:6–13

    Article  PubMed  Google Scholar 

  • Cahlon O, Zelefsky MJ, Shippy A et al (2008) Ultra-high dose (86.4 Gy) IMRT for localized prostate cancer: toxicity and biochemical outcomes. Int J Radiat Oncol Biol Phys 71(2):330–337

    Article  PubMed  CAS  Google Scholar 

  • Carlson DJ, Stewart RD, Li XA et al (2004) Comparison of in vitro and in vivo α/β ratios for prostate cancer. Phys Med Biol 49:4477–4491

    Article  PubMed  Google Scholar 

  • Chen L, Price RA, Wang L et al (2004) MRI-based treatment planning for radiotherapy: dosimetric verification for prostate IMRT. Int J Radiat Oncol Biol Phys 60:636–647

    Article  PubMed  Google Scholar 

  • Clancy PE, Schuller BW, Sroczinski LM, Hirsch AE (2009) Assessment of patient setup error in prostate radiation therapy using fiducial-based image guided radiation therapy with kV onboard imaging and conebeam CT [abstract]. Int J Radiat Oncol Biol Phys 75(suppl 1):S579–S580

    Article  Google Scholar 

  • Coote JH, Wylie JP, Cowan RA et al (2009) Hypofractionated intensity-modulated radiotherapy for carcinoma of the prostate: analysis of toxicity. Int J Radiat Oncol Biol Phys 74(4):1121–1127

    Article  PubMed  Google Scholar 

  • de Crevoisier R, Tucker SL, Dong L et al (2005) Increased risk of biochemical and local failure in patients with distended rectum on the planning CT for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys 62:965–973

    Article  PubMed  Google Scholar 

  • Dearnaley DP, Sydes MR, Graham JD et al (2007) Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial. Lancet Oncol 8(6):475–487

    Article  PubMed  Google Scholar 

  • Faria SL, Souhami L, Joshua B et al (2008) Reporting late rectal toxicity in prostate cancer patients treated with curative radiation treatment. Int J Radiat Oncol Biol Phys 72(3):777–781

    Article  PubMed  Google Scholar 

  • Franiel T, Ludemann L, Taupitz M et al (2009) MRI before and after external beam intensity-modulated radiotherapy of patients with prostate cancer: the feasibility of monitoring of radiation-induced tissue changes using dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence. Radiother Oncol 93:241–245

    Article  PubMed  Google Scholar 

  • Freedman GM, Price RA Jr, Mah D et al (2001) Routine use of MRI and CT simulation for treatment planning of intensity modulated radiation therapy (IMRT) in prostate cancer. Int J Radiat Oncol Biol Phys 51:301

    Article  Google Scholar 

  • Friedland JL, Freeman DE, Masterson-McGary ME et al (2009) Stereotactic body radiotherapy: an emerging treatment approach for localized prostate cancer. Technol Cancer Res Treat 8(5):387–392

    PubMed  CAS  Google Scholar 

  • Gao Z, Wilkins D, Eapen L et al (2007) A study of prostate delineation referenced against a gold standard created from the visible human data. Radiother Oncol 85:239–246

    Article  PubMed  Google Scholar 

  • Ghadjar P, Gwerder N, Manser P et al (2010) High-dose (80 Gy) intensity modulated radiation therapy with daily image-guidance as primary treatment for localized prostate cancer. Strahlenther Onkol 186(12):687–692

    Article  PubMed  Google Scholar 

  • Groenendaal G, Moman MR, Korporaal JG et al (2010a) Validation of functional imaging with pathology for tumor delineation in the prostate. Radiother Oncol 94:145–150

    Article  PubMed  Google Scholar 

  • Groenendaal G, van den Berg Cornelis AT, Korporaal JG et al (2010b) Simultaneous MRI diffusion and perfusion imaging for tumor delineation in prostate cancer patients. Radiother Oncol 95:185–190

    Article  PubMed  Google Scholar 

  • Haverkort MAD, van der Kamer JB, Pieters BR et al (2011) Position verification for the prostate: effect on rectal wall dose. Int J Radiat Oncol Biol Phys 80:462–468

    Article  PubMed  Google Scholar 

  • Heemsbergen WD, Hoogeman MS, Witte MG et al (2007) Increased risk of biochemical and clinical failure for prostate patients with a large rectum at radiotherapy planning: results from the Dutch trial of 68 GY versus 78 Gy. Int J Radiat Oncol Biol Phys 67:1418–1424

    Article  PubMed  CAS  Google Scholar 

  • Intensity Modulated Radiation Therapy Collaborative Working Group (2001) Intensity-modulated radiotherapy: current status and issues of interest. Int J Radiat Oncol Biol Phys 51(4):880–914

    Article  Google Scholar 

  • Jackson ASN, Reinsberg SA, Moore EM et al (2004) Distortion-corrected T2-weighted MRI: a comparison with CT for prostate contouring in radiotherapy planning. Radiother Oncol 73:S457

    Google Scholar 

  • Junius S, Haustermans K, Bussels B et al (2007) Hypofractionated intensity modulated irradiation for localized prostate cancer, results from a phase I/II feasibility study. Radiat Oncol 2:29

    Article  PubMed  Google Scholar 

  • Kajihara H, Hayashida Y, Murakami R et al (2009) Usefulness of diffusion-weighted imaging in the localization of prostate cancer. Int J Radiat Oncol Biol Phys 74:399–403

    Article  PubMed  Google Scholar 

  • Katz AJ, Santoro M, Ashley R et al (2010) Stereotactic body radiotherapy for organ-confined prostate cancer. BMC Urol 10:1

    Article  PubMed  Google Scholar 

  • King CR, Brooks JD, Gill H et al (2009) Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial. Int J Radiat Oncol Biol Phys 73(4):1043–1048

    Article  PubMed  Google Scholar 

  • King CR, Brooks JD, Gill H et al (2012) Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer. Int J Radiat Oncol Biol Phys 82(2):877–882

    Google Scholar 

  • Kitamura K, Shirato H, Seppenwoolde Y et al (2002) Three-dimensional intrafractional movement of prostate measured during real-time tumor-tracking radiotherapy in supine and prone treatment positions. Int J Radiat Oncol Biol Phys 53:1117–1123

    Article  PubMed  Google Scholar 

  • Kuban DA, Tucker SL, Dong L et al (2008) Long-term results of the M. D. Anderson randomized dose-­escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys 70(1):67–74

    Article  PubMed  Google Scholar 

  • Kupelian PA, Reddy CA, Carlson TP et al (2002) Preliminary observations on biochemical relapse-free survival rates after short-course intensity-modulated radiotherapy (70 Gy at 2.5 Gy/fraction) for localized prostate cancer. Int J Radiat Oncol Biol Phys 53(4):904–912

    Article  PubMed  Google Scholar 

  • Kupelian PA, Willoughby TR, Meeks SL et al (2005) Intraprostatic fiducials for localization of the prostate gland: monitoring intermarker distances during radiation therapy to test for marker stability. Int J Radiat Oncol Biol Phys 62:1291–1296

    Article  PubMed  Google Scholar 

  • Kupelian PA, Willoughby TR, Reddy CA et al (2007) Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland clinic experience. Int J Radiat Oncol Biol Phys 68(5):1424–1430

    Article  PubMed  Google Scholar 

  • Kupelian PA, Willoughby TR, Reddy CA et al (2008) Impact of image-guided on outcomes after external beam radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 70:1146–1150

    Article  PubMed  Google Scholar 

  • Langen KM, Willoughby TR, Meeks SL et al (2008) Observations on real-time prostate gland motion using electromagnetic tracking. Int J Radiat Oncol Biol Phys 71:1084–1090

    Article  PubMed  Google Scholar 

  • Leborgne F, Fowler J (2009) Late outcomes following hypofractionated conformal radiotherapy vs standard fractionation for localized prostate cancer: a nonrandomized contemporary comparison. Int J Radiat Oncol Biol Phys 74:1441–1446

    Article  PubMed  Google Scholar 

  • Leborgne F, Fowler J, Leborgne JH, Mezzera J. (2012) Later outcomes and alpha/beta estimate from hypofractionated conformal three-dimensional radiotherapy versus standard fractionation for localized prostate cancer. Int J Radiat Oncol Biol Phys 82(3):1200–1207

    Google Scholar 

  • Lips I, Dehnad H, Kruger AB et al (2007) Health-related quality of life in patients with locally advanced prostate cancer after 76 Gy intensity-modulated radiotherapy vs. 70 Gy conformal radiotherapy in a prospective and longitudinal study. Int J Radiat Oncol Biol Phys 69(3):656–661

    Article  PubMed  Google Scholar 

  • Lock M, Best L, Wong E et al (2011) A phase II trial of Arc-based hypofractionated intensity-modulated radiotherapy in localized prostate cancer. Int J Radiat Oncol Biol Phys 80(5):1306–1315

    Article  PubMed  Google Scholar 

  • Madsen BL, Hsi RA, Pham HT et al (2007) Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: first clinical trial results. Int J Radiat Oncol Biol Phys 67(4):1099–1105

    Article  PubMed  Google Scholar 

  • Martin JM, Rosewall T, Bayley A et al (2007) Phase II trial of hypofractionated image-guided intensity-modulated radiotherapy for localized prostate adenocarcinoma. Int J Radiat Oncol Biol Phys 69(4):1084–1089

    Article  PubMed  Google Scholar 

  • Martin JM, Frantzis J, Eade T, Chung P (2010) Clinician’s guide to prostate IMRT plan assessment and optimisation. J Med Imaging Radiat Oncol 54(6):569–575

    Article  PubMed  CAS  Google Scholar 

  • McLaughlin PW, Evans C, Feng M, Narayana V (2010) Radiographic and anatomic basis for prostate contouring errors and methods to improve prostate contouring accuracy. Int J Radiat Oncol Biol Phys 76:369–378

    Article  PubMed  Google Scholar 

  • Meirovitz A, Troyer S, Evans V et al (2003) Rectum and prostate separation by MRI vs CT in external beam and post-implant patients [abstract]. Int J Radiat Oncol Biol Phys 57(Suppl):S334

    Article  Google Scholar 

  • Milosevic M, Voruganti S, Blend R et al (1998) Magnetic resonance imaging (MRI) for localization of the prostatic apex: comparison to computed tomography (CT) and urethrography. Radiother Oncol 47:277–284

    Article  PubMed  CAS  Google Scholar 

  • Miralbell R, Roberts SA, Zubizarreta E et al (2012) Dose-fractionation sensitivity of prostate cancer deduced from radiotherapy outcomes of 5,969 patients in seven international institutional datasets: α/β  =  1.4 (0.9–2.2) Gy. Int J Radiat Oncol Biol Phys 82:e17–e24

    Article  PubMed  Google Scholar 

  • Mitchell DM, Perry L, Smith S et al (2009) Assessing the effect of a contouring protocol on postprostatectomy radiotherapy clinical target volumes and interphysician variation. Int J Radiat Oncol Biol Phys 75:990–993

    Article  PubMed  Google Scholar 

  • Neicu T, Chetty IJ, Pradhan D et al (2009) A comparative study for daily localization with 3D ultrasound, cone beam CT, and implanted prostate fiducial markers for patients undergoing IGRT for prostate cancer. Int J Radiat Oncol Biol Phys 75(Suppl):S606

    Article  Google Scholar 

  • Owen R, Foroudi F, Kron T et al (2010) A comparison of in-room computerized tomography options for detection of fiducial markers in prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys 77:1248–1256

    Article  PubMed  Google Scholar 

  • Parker CC, Damyanovich A, Haycocks T et al (2003) Magnetic resonance imaging in the radiation treatment planning of localized prostate cancer using intra-prostatic fiducial markers for computed tomography co-registration. Radiother Oncol 66:217–224

    Article  PubMed  CAS  Google Scholar 

  • Peeters ST, Heemsbergen WD, Koper PC et al (2006) Dose–response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy. J Clin Oncol 24(13):1990–1996

    Article  PubMed  Google Scholar 

  • Perna L, Fiorino C, Cozzarini C et al (2009) Sparing the penile bulb in the radical irradiation of clinically localised prostate carcinoma: a comparison between MRI and CT prostatic apex definition in 3DCRT, Linac-IMRT and helical tomotherapy. Radiother Oncol 93:57–63

    Article  PubMed  Google Scholar 

  • Petersch B, Bogner J, Fransson A et al (2004) Effects of geometric distortion in 0.2 T MRI on radiotherapy treatment planning of prostate cancer. Radiother Oncol 71:55–64

    Article  PubMed  Google Scholar 

  • Pinkawa M, Siluschek J, Gagel B et al (2006) Influence of the initial rectal distension on posterior margins in primary and postoperative radiotherapy for prostate cancer. Radiother Oncol 8:284–290

    Article  Google Scholar 

  • Pouliot J, Morin O, Aubin M et al (2006) Mégavoltage cone-beam CT: récents développements et applications cliniques pour la radiothérapie de modulation d’intensité. Cancer Radiother 10:258–268

    Article  PubMed  CAS  Google Scholar 

  • Rasch C, Barillot I, Remeijer P et al (1999) Definition of the prostate in CT and MRI: a multi-observer study. Int J Radiat Oncol Biol Phys 43:57–66

    Article  PubMed  CAS  Google Scholar 

  • Rene N, Faria S, Cury F et al (2010) Hypofractionated radiotherapy for favorable risk prostate cancer. Int J Radiat Oncol Biol Phys 77(3):805–810

    Article  PubMed  Google Scholar 

  • Roach M III, Faillace-Akazawa P, Malfatti C et al (1996) Prostate volumes defined by magnetic imaging and computerized tomographic scans for three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 35:1011–1018

    Article  PubMed  Google Scholar 

  • Rosewall T, Kong V, Vesprini D et al (2009) Prostate deli­neation using CT and MRI for radiotherapy patients with bilateral hip prostheses. Radiother Oncol 90:325–330

    Article  PubMed  Google Scholar 

  • Sanguineti G, Cavey ML, Endres EJ et al (2006) Does treatment of the pelvic nodes with IMRT increase late rectal toxicity over conformal prostate-only radiotherapy to 76 Gy? Strahlenther Onkol 182(9):543–549

    Article  PubMed  Google Scholar 

  • Sannazzari GL, Ragona R, Ruo Redda MG et al (2002) CT-MRI image fusion for delineation of volumes in three-dimensional conformal radiation therapy in the treatment of localized prostate cancer. Br J Radiol 75:603–607

    PubMed  CAS  Google Scholar 

  • Sathya JR, Davis IR, Julian JA, Guo Q (2005) Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate. J Clin Oncol 23(6):1192–1199

    Article  PubMed  Google Scholar 

  • Scarbrough TJ, Golden NM, Ting JY et al (2006) Comparison of ultrasound and implanted seed marker prostate localization methods: implications for image-guided radiotherapy. Int J Radiat Oncol Biol Phys 65:378–387

    Article  PubMed  Google Scholar 

  • Sharma NK, Li T, Chen DY, Pollack A et al (2011) Intensity-modulated radiotherapy reduces gastrointestinal toxicity in patients treated with androgen deprivation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 80(2):437–444

    Article  PubMed  Google Scholar 

  • Smith WL, Lewis C, Bauman G et al (2007) Prostate volume contouring: a 3D analysis of segmentation using 3DTRUS, CT and MR. Int J Radiat Oncol Biol Phys 67:1238–1247

    Article  PubMed  Google Scholar 

  • Sorcini B, Tilikidis A (2006) Clinical application of image-guided radiotherapy (IGRT) (on the Varian OBI platform). Cancer Radiother 10:252–257

    Article  PubMed  Google Scholar 

  • Steenbakkers RJHM, Deurloo KEI, Nowak PJCM et al (2003) Reduction of dose delivered to the rectum and bulb of the penis using MRI delineation for radiotherapy of the prostate. Int J Radiat Oncol Biol Phys 57:1269–1279

    Article  PubMed  Google Scholar 

  • Tanaka O, Hayashi S, Sakurai K et al (2006) Importance of the CT/MRI fusion method as a learning tool for CT-based postimplant dosimetry in prostate brachytherapy. Radiother Oncol 81:303–308

    Article  PubMed  Google Scholar 

  • Tang CI, Loblaw DA, Cheung P et al (2008) Phase I/II study of a five-fraction hypofractionated accelerated radiotherapy treatment for Low-risk localised prostate cancer: early results of pHART3. Clin Oncol 20:729–737

    Article  CAS  Google Scholar 

  • Usmani N, Sloboda R, Kamal W et al (2011) Can images obtained with high field strength magnetic resonance imaging reduce contouring variability of the prostate? Int J Radiat Oncol Biol Phys 80:728–734

    Article  PubMed  Google Scholar 

  • Valicenti RK, Sweet JW, Hauck WW et al (1999) Variation of clinical target volume definition in three-dimensional conformal radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 44:931–935

    Article  PubMed  CAS  Google Scholar 

  • Veldeman L, Madani I, Hulstaert F et al (2008) Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol 9(4):367–375

    Article  PubMed  Google Scholar 

  • Vesprini D, Sia M, Lockwood G, Moseley D et al (2011) Role of principal component analysis in predicting toxicity in prostate cancer patients treated with hypofractionated intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 81:e415–e421

    Article  PubMed  Google Scholar 

  • Villeirs GM, Verstraete KL, De Neve WJ, De Meerleer GO (2005) Magnetic resonance imaging anatomy of the prostate and periprostatic area: a guide for radiotherapists. Radiother Oncol 76:99–106

    Article  PubMed  Google Scholar 

  • Vora SA, Wong WW, Schild SE et al (2007) Analysis of biochemical control and prognostic factors in patients treated with either low-dose three-dimensional conformal radiation therapy or high-dose intensity-­modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 68(4):1053–1058

    Article  PubMed  CAS  Google Scholar 

  • Wang JZ, Guerrero M, Li XA (2003) How low is the α/β ratio for prostate cancer? Int J Radiat Oncol Biol Phys 55:194–203

    Article  PubMed  Google Scholar 

  • Yassa M, Fortin B, Fortin MA et al (2008) Combined hypofractionated radiation and hormone therapy for the treatment of intermediate-risk prostate cancer. Int J Radiat Oncol Biol Phys 71(1):58–63

    Article  PubMed  Google Scholar 

  • Yeoh EE, Botten RJ, Butters J et al (2010) Hypofractionated versus conventionally fractionated radiotherapy for prostate carcinoma: final results of phase III randomized trial. Int J Radiat Oncol Biol Phys 81:1271–1278

    Article  PubMed  Google Scholar 

  • Zelefsky MJ, Fuks Z, Happersett L et al (2000) Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer. Radiother Oncol 55(3):241–249

    Article  PubMed  CAS  Google Scholar 

  • Zelefsky MJ, Fuks Z, Hunt M et al (2002) High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in n772 patients. Int J Radiat Oncol Biol Phys 53(5):1111–1116

    Article  PubMed  Google Scholar 

  • Zelefsky MJ, Yamada Y, Fucks Z et al (2008a) Long-term results of conformal radiotherapy for prostate cancer: impact of dose escalation on biochemical tumor ­control and distant metastases free survival outcomes. Int J Radiat Oncol Biol Phys 71:1028–1033

    Article  PubMed  Google Scholar 

  • Zelefsky MJ, Levin EJ, Hunt M et al (2008b) Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 70(4):1124–1129

    Article  PubMed  Google Scholar 

  • Zerini D, Jereczek-Fossa BA, Vavassori A et al (2010) 3D-conformal hypofractionated radiotherapy for prostate cancer with daily transabdominal ultrasonography prostate localization: toxicity and outcome of a pilot study. Tumori 96(6):941–946

    PubMed  Google Scholar 

  • Zietman AL, DeSilvio ML, Slater JD et al (2005) Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA 294(10):1233–1239

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Centre Hospitalier Lyon Sud, University Claude Bernard Lyon 1, EA3738, Pierre Benite, France

    Olivier Chapet M.D., Ph.D., Corina Udrescu & Ciprian Enachescu M.D.

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  1. Olivier Chapet M.D., Ph.D.
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  2. Corina Udrescu
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  3. Ciprian Enachescu M.D.
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Correspondence to Olivier Chapet M.D., Ph.D. .

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  1. , Department of Oncology and Radiotherapy, University Hospital, BP 217X, Grenoble, 38043, France

    Michel Bolla

  2. , Department of Urology, University Hospital, Herestraat 49, Leuven, 3000, Belgium

    Hendrik van Poppel

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Chapet, O., Udrescu, C., Enachescu, C. (2012). Intensity Modulated Radiotherapy for Prostate Cancer. In: Bolla, M., van Poppel, H. (eds) Management of Prostate Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27597-5_12

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