Abstract
There has been increasing interest of clinicians in the high frequency of acute kidney injury (AKI) in acute heart failure (AHF). The most important mechanism behind cardiorenal syndrome type 1 is frequently an iatrogenic derangement caused by inappropriate use of diuretics or other strategies to alleviate congestion such as extracorporeal ultrafiltration [1]. In the attempt to remove fluid overload, severe hemodynamic consequences may lead to renal hypoperfusion and AKI.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ronco C, McCullough PA, Anker SD, et al (2010) Cardiorenal syndromes: an executive summary from the consensus conference of the Acute Dialysis Quality Initiative (ADQI). Contrib Nephrol 165: 54–67
Ronco C, Grammaticopoulos S, Rosner M, et al (2010) Oliguria, creatinine and other biomarkers of acute kidney injury. Contrib Nephrol 164: 118–127
Coca SG, Yalavarthy R, Concato J, Parikh CR (2008) Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int 73: 1008–1016
Paragas N, Qiu A, Zhang Q, et al (2011) The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat Med 17: 216–222
Koyner JL, Bennett MR, Worcester EM, et al (2008) Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int 74: 1059–1069
Aghel A, Shrestha K, Mullens W, Borowski A, Tang WH (2010) Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. J Card Fail 16: 49–54
Nickolas TL, O’Rourke MJ, Yang J, et al (2008) Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 148: 810–819
Alvelos M, Pimentel R, Pinho E, et al (2011) Neutrophil gelatinase-associated lipocalin in the diagnosis of type 1 cardiorenal syndrome in the general ward. Clin J Am Soc Nephrol 6: 476–481
Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268: 10425–10432
Flo TH, Smith KD, Sato S, et al (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432: 917–921
Mishra J, Ma Q, Prada A, et al (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534–2543
Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P (2004) Neutrophil gelatinaseassociated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 24: 307–315
Mishra J, Dent C, Tarabishi R, et al (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365: 1231–1238
Kusaka M, Kuroyanagi Y, Mori T, et al (2008) Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death. Cell Transplant 17: 1–100
Dent C, Ma Q, Dastrala S, et al (2007) Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care 11: R127
Zappitelli M, Washburn KK, Arikan AA, et al (2007) Urine neutrophil gelatinase associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care 11: R84
Cruz DN, de Cal M, Garzotto F, et al (2010) Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. Intensive Care Med 36: 444–451
de Geus HR, Bakker J, Lesaffre EM, le Noble JL (2011) Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients. Am J Respir Crit Care Med 183: 907–914
Shapiro NI, Trzeciak S, Hollander JE, et al (2010) The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med 56: 52–59
Haase-Fielitz A, Bellomo R, Devarajan P, et al (2009) Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery—a prospective cohort study. Crit Care Med 37: 553–560
Makris K, Markou N, Evodia E, et al (2009) Urinary neutrophil gelatinase-associated lipocalin (NGAL)as an early marker of acute kidney injury in critically ill multiple trauma patients. Clin Chem Lab Med 47: 79–82
Malyszko J, Bachorzewska-Gajewska H, Poniatowski B, Malyszko JS, Dobrzycki S (2009) Urinary and serum biomarkers after cardiac catheterization in diabetic patients with stable angina and without severe chronic kidney disease. Renal Failure 31: 910–919
Wasilewska A, Zoch-Zwierz W, Taranta-Janusz K, Michaluk-Skutnik J (2010) Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of cyclosporine nephrotoxicity? Pediatr Nephrol 25: 889–897
Yilmaz A, Sevketoglu E, Gedikbasi A, et al (2009) Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol 24: 2387–2392
Bagshaw SM, Bennett M, Haase M, et al (2010) Plasma and urine neutrophil gelatinaseassociated lipocalin in septic versus non-septic acute kidney injury in critical illness Intensive Care Med 36: 452–461
Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A; NGAL Meta-analysis Investigator Group (2009) Accuracy of neutrophil gelatinase-associated lipocalin (ngal) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis 54: 1012–1024
Damman K, Voors AA, Hillege HL, et al (2010) Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality. Eur J Heart Fail 12: 974–982
Valle R, Aspromonte N, Milani L, et al (2011) Optimizing fluid management in patients with acute decompensated heart failure (ADHF): the emerging role of combined measurement of body hydration status and brain natriuretic peptide (BNP) levels. Heart Fail Rev 16: 519–529
Gottlieb SS, Abraham W, Butler J, et al (2002) The prognostic importance of different definitions of worsening renal function in congestive heart failure. J Card Fail 8: 136–141
Costanzo MR, Guglin ME, Saltzberg MT, et al (2007) Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol 49: 675–683
Cai L, Rubin J, Han W, Venge P, Xu S (2010) The origin of multiple molecular forms in urine of HNL/NGAL. Clin J Am Soc Nephrol 5: 2229–2235
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Ronco, C., Noland, B. (2012). NGAL Curve for the Early Diagnosis of AKI in Heart Failure Patients. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2012. Annual Update in Intensive Care and Emergency Medicine, vol 2012. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25716-2_56
Download citation
DOI: https://doi.org/10.1007/978-3-642-25716-2_56
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-25715-5
Online ISBN: 978-3-642-25716-2
eBook Packages: MedicineMedicine (R0)