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Pathophysiologie der Leberkrankheiten

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Pädiatrische Gastroenterologie, Hepatologie und Ernährung

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Zusammenfassung

In der sinusoidalen Membran beginnt die Gallebildung. Rezeptoren und Transporter erleichtern die Aufnahme und den Eintritt von Gallensäuren, Bilirubin, Fettsäuren und anderen Gallekomponenten in die Leberzelle. Diese enthält Rezeptoren für Glykoproteine, Asialoglykoprotein, Immunglobulin A (Ig A), vasoaktives intestinales Peptid (VIP), Insulin, Glukagon und „epidermal growth factor“ (EGF). Ein primär aktiver Transport erfolgt durch die Na+-K+-ATPase, die einen Ionengradienten an der Zellmembran aufbaut und innerhalb der Zelle ein negatives elektrisches Potenzial erzeugt (wodurch die Diffusion erleichtert wird). Dieser Ionengradient ermöglicht die Arbeit anderer Carrier gegen das Konzentrationsgefälle, z. B. von NTCP (Natrium-Taurocholsäure-Kotransport-Polypeptid), das auch für zahlreiche Medikamente, Östrogene und zyklische Oligopeptide spezifisch ist. Transporter für organische Anionen (OATP1) und anorganische Ionen wurden ebenfalls nachgewiesen.

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Authors and Affiliations

  1. Universitätsklinik für Kinder- und Jugendheilkunde Graz, Auenbruggerplatz 30, 8010, Graz, Österreich

    Johann Deutsch Prof. Dr.

  2. Universitätsklinik für Kinder- und Jugendheilkunde, Währinger Gürtel 18–20, 1090, Wien, Österreich

    Wolf-Dietrich Huber Dr.

  3. Christliches Kinderhospital Osnabrück, Zentrum für Kinder- und Jugendmedizin, Johannisfreiheit 1, 49074, Osnabrück, Deutschland

    Burkhard Rodeck Priv.-Doz. Dr.

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  1. Johann Deutsch Prof. Dr.
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  2. Wolf-Dietrich Huber Dr.
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  3. Burkhard Rodeck Priv.-Doz. Dr.
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Editors and Affiliations

  1. Zentrum für Kinder- und Jugendmedizin, Christliches Kinderhospital Osnabrück, Johannisfreiheit 1, 49074, Osnabrück, Deutschland

    Burkhard Rodeck Priv.-Doz. Dr.

  2. Abteilung Allgemeine Pädiatrie und Neonatalogie, Universitätsklinikum Gießen und Marburg GmbH, Zentrum für Kinderheilkunde und Jugendmedizin, Feulgenstr. 12, 35392, Gießen, Deutschland

    Klaus-Peter Zimmer Prof. Dr.

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Deutsch, J., Huber, WD., Rodeck, B. (2013). Pathophysiologie der Leberkrankheiten. In: Rodeck, B., Zimmer, KP. (eds) Pädiatrische Gastroenterologie, Hepatologie und Ernährung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24710-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-24710-1_14

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