Abstract
Traditional Chinese Medicine have the secret is dosage, the Traditional Chinese Medical clinical therapeutic effect key is prescription’ dosage. The paper aim to explore and analyze the relationship between TCM prescription’ dosage and pharmacodynamic effect. The methods: the rats were done into diabetic model,and taken Gegen Qinlian Decoction(Radix Puerariae, Radix Scutellariae, Rhizoma Coptidis, Glycyrrhiza uralensis) which have been design using Uniform Design(UD) method, extract pharmacodynamic effect indexs from the rats, analyze the relationship between TCM prescription’ dosage and pharmacodynamic based on Orthogonal Partial Least Square Analysis(OPLS) /O2PLS.The result indicate the order of Variable importance is Radix Puerariae, Rhizoma Coptidis, Glycyrrhiza uralensis, Radix Scutellariae,and the Coefficients of TCM relative to the pharmacodynamic effect indexs.
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Nie, B. et al. (2011). Analyze the Relationship between TCM Prescription’ Dosage and Pharmacodynamic Effect Based on UD-OPLS/O2PLS. In: Shen, G., Huang, X. (eds) Advanced Research on Computer Science and Information Engineering. CSIE 2011. Communications in Computer and Information Science, vol 153. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21411-0_14
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DOI: https://doi.org/10.1007/978-3-642-21411-0_14
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