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What Else Besides TBE and Borreliosis? Tick-Transmitted Pathogens in Germany and Beyond

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Progress in Parasitology

Part of the book series: Parasitology Research Monographs ((Parasitology Res. Monogr.,volume 2))

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Abstract

Tick-borne diseases are an important problem in European countries. In this chapter, we review the biology and distribution of five tick-transmitted pathogens in Germany and neighbouring countries Austria and Switzerland. We focus on the bacterial pathogens Rickettsia spp., Anaplasma phagocytophilum and Francisella tularensis, the protozoan parasite Babesia spp. as well as on Eyach virus. The diagnosis of these pathogens is difficult, because the majority of the infections result in mild or self-limited diseases. However, all these pathogens may induce severe clinical symptoms; therefore, their importance is not to be underestimated in the diagnosis of tick-borne diseases.

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References

  • Al Dahouk S, Nöckler K, Tomaso H, Splettstoesser WD, Jungersen G, Riber U, Petry T, Hoffmann D, Scholz HC, Hensel A, Neubauer H (2005) Seroprevalence of brucellosis, tularemia, and yersiniosis in wild boars (Sus scrofa) from north-eastern Germany. J Vet Med B 52:444–455

    CAS  Google Scholar 

  • Azad AF, Beard CB (1998) Rickettsial pathogens and their arthropod vectors. Emerg Infect Dis 4(2):179–186

    PubMed  CAS  Google Scholar 

  • Bakken JS, Dumler JS (2000) Human granulocytic ehrlichiosis. Clin Infect Dis 31:554–560

    PubMed  CAS  Google Scholar 

  • Bätzing-Feigenbaum J, Brenner H, Kallischnigg G, Rüden H, Talaska T (2002) Seroprevalence of antibodies against the agent of the “Human Granulocytic Ehrlichiosis” (HGE) in high risk populations of foresters in the Federal Laender of Hesse (northern part), Brandenburg and Berlin, Germany. Int J Med Microbiol 291(Suppl 33):194–195

    Google Scholar 

  • Baumann D, Pusterla N, Peter O, Grimm F, Fournier PE, Schär G, Bossart W, Lutz H, Weber R (2003) Fieber nach Zeckenstich: Klinik und Diagnostik von akuten Zeckenstich-assoziierten Infektionskrankheiten in der Nordostschweiz. Dtsch Med Wochenschr 128:1042–1047, In German

    PubMed  CAS  Google Scholar 

  • Baumgarten BU, Röllinghoff M, Bogdan C (1999) Prevalence of Borrelia burgdorferi and granulocytic and monocytic ehrlichiae in Ixodes ricinus ticks from southern Germany. J Clin Microbiol 37(11):3448–3451

    PubMed  CAS  Google Scholar 

  • Bernasconi MV, Casati S, Peter O, Piffaretti JC (2002) Rhipicephalus ticks infected with Rickettsia and Coxiella in Southern Switzerland (Canton Ticino). Infect Genet Evol 2:111–120

    PubMed  CAS  Google Scholar 

  • Blaschitz M, Narodoslavsky-Gföller M, Kanzler M, Stanek G, Walochnik J (2008a) Babesia species occurring in Austrian Ixodes ricinus ticks. Appl Environ Microbiol 74(15):4841–4846

    PubMed  CAS  Google Scholar 

  • Blaschitz M, Narodoslavsky-Gföller M, Kanzler M, Walochnik J, Stanek G (2008b) First detection of Rickettsia helvetica in Ixodes ricinus ticks in Austria. Vector Borne Zoonotic Dis 8(4):561–563

    PubMed  Google Scholar 

  • Boretti FS, Perreten A, Meli ML, Cattori V, Willi B, Wengi N, Hornok S, Honegger H, Hegglin D, Woelfel R, Reusch CE, Lutz H, Hofmann-Lehmann R (2009) Molecular investigations of Rickettsia helvetica infection in dogs, foxes, humans and Ixodes ticks. Appl Environ Microbiol 75(10):3230–3237, 27

    PubMed  CAS  Google Scholar 

  • Bowen GS (1988) Colorado tick fever. In: Monath TP (ed) The arboviruses: epidemiology and ecology, vol II. CRC Press, Florida, pp 159–176

    Google Scholar 

  • Braun R, Hassler D, Kimmig P (1999). Seltenere Zecken-übertragene Krankheiten Teil II: Viren, Tularämie und Babesiose. Available at www.baxter.de/fachkreise/artikel/ellipse_fsme_teil2.pdf. In German

  • Burgdorfer W, Aeschlimann A, Peter O, Hayes SF, Philip RN (1979) Ixodes ricinus: vector of a hitherto undescribed spotted fever group agent in Switzerland. Acta Trop 36:357–367

    PubMed  CAS  Google Scholar 

  • Casati S, Sager H, Gern L, Piffaretti JC (2006) Presence of potetially pathogenic Babesia sp. for human in Ixodes ricinus in Switzerland. Ann Agric Environ Med 13:65–70

    PubMed  CAS  Google Scholar 

  • Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, Frolova TV, Gould EA, Gritsun TS, Heinz FX, Labuda M, Lashkevich VA, Loktev V, Lundkvist A, Lvov DV, Mandi CW, Niedrig M, Papa A, Petrov VS, Plyusnin A, Randolph S, Süss J, Zlobin VI, de Lamallerie X (2004) Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect 10:1040–1055

    PubMed  CAS  Google Scholar 

  • Chastel C, Main AJ, Couatarmanac’h A, Le Lay G, Knudson DL, Ouillen MC, Beaucournu JC (1984) Isolation of Eyach virus (Reoviridae, Colorado Tick Fever group) from Ixodes ricinus and I. ventalloi in ticks in France. Arch Virol 82:161–171

    PubMed  CAS  Google Scholar 

  • Dautel H, Dippel C, Oehme R, Hartelt K, Schettler E (2006) Evidence for an increased geographical distribution of Dermacentor reticulatus in Germany and detection of Rickettsia sp. RpA4. Int J Med Microbiol 296(Suppl 1):149–156

    PubMed  Google Scholar 

  • Deutz A, Fuchs K, Schuller W, Nowotny N, Auer H, Aspöck H, Stünzner D, Kerbl U, Klement C, Köfer J (2003) Seroepidemiologische Untersuchung von Jägern auf Zoonosen in Südösterreich – Prävalenzen, Risikopotentiale und Vorbeugemaßnahmen. Berl Münch Tierärztl Wochenschr 116:306–311, In German

    PubMed  Google Scholar 

  • Dobec M, Golubic D, Punda-Polic V, Kaeppeli F, Sievers M (2009) Rickettsia helvetica in Dermacentor reticulatus ticks. Emerg Infect Dis 15(1):98–100

    PubMed  Google Scholar 

  • Dobler G, Wölfel R (2009) Typhus and other rickettsioses. Dtsch Arztebl Int 106(20):28

    Google Scholar 

  • Dobler G, Wölfel R, Schmüser H, Essbauer S, Pfeffer M (2006) Seroprevalence of tick-borne and mosquito-borne arboviruses in European brown hares in Northern and Western Germany. Int J Med Microbiol 296(Suppl 1):80–83

    PubMed  Google Scholar 

  • Dobler G, Essbauer S, Terzioglu R, Thomas A, Wölfel R (2008) Häufigkeit des Frühsommer-Meningoenzephalitis-Virus und von Rickettsien in Zecken aus dem Burgenland (Österreich). Wien Klin Wochenschr 120(Suppl 4):45–48, In German

    PubMed  Google Scholar 

  • Dumler JS, Barbet AF, Bekker CPJ, Dasch GA, Palmer GH, Ray SC, Rikihisa Y, Rurangirwa FR (2001) Reorganisation of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, description of six new species combinations and designation of Ehrlichia equi and ‘HGE agent’ as subjective synonyms of Ehrlichia phagocytophila. Int J Syst Evol Microbiol 51:2145–2165

    PubMed  CAS  Google Scholar 

  • Ellis J, Oyston PCF, Green M, Titball RW (2002) Tularemia. Clin Microbiol Rev 15(4):631–646

    PubMed  Google Scholar 

  • Foppa JM, Krause PJ, Spielman A, Goethert H, Gern L, Brand B, Telford SR 3rd (2002) Entomologic and serologic evidence of zoonotic transmission of Babesia microti, eastern Switzerland. Emerg Infect Dis 8(7):722–726

    PubMed  Google Scholar 

  • Fournier PE, Grunnenberger F, Jaulhac B, Gastinger G, Raoult D (2000) Evidence of Rickettsia helvetica infection in humans, eastern France. Emerg Infect Dis 6(4):389–392

    PubMed  CAS  Google Scholar 

  • Fournier PE, Allombert C, Supputamongkol Y, Caruso G, Brouqui P, Raoult D (2004) Aneruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. J Clin Microbiol 42(2):816–818

    PubMed  Google Scholar 

  • Friedl A, Heinzer I, Fankhauser H (2005) Tularemia after a dormouse bite in Switzerland. Eur J Clin Microbiol Infect Dis 24:352–354

    PubMed  CAS  Google Scholar 

  • Gillespie JJ, Beier MS, Rahman MS, Ammermann NC, Shallom JM, Purkayastha A, Sobral BS, Azad AF (2007) Plasmids and rickettsial evolution: insights from Rickettsia felis. PLoS ONE 2(3):e266

    PubMed  Google Scholar 

  • Granström M (1997) Tick-borne zoonoses in Europe. Clin Microbiol Infect 3:156–167

    PubMed  Google Scholar 

  • Gray JS, Dautel H, Estrada-Pena A, Kahl O, Lindgren E (2009) Effects of climate change on ticks and tick-borne diseases in Europe. Interdiscip Perspect Infect Dis 2009:593232. Epub ahead of print

    Google Scholar 

  • Gray J, Zintl A, Hildebrandt A, Hunfeld KP, Weiss L (2010) Zoonotic babesiosis: overview of the disease and novel aspects of pathogen identity. Ticks Tick-borne Dis 1:3–10

    PubMed  Google Scholar 

  • Grunow R, Priebe HS (2007) Tularämie - zum Vorkommen in Deutschland. Epidemiologisches Bulletin 7/2007. Available from http://www.rki.de/cln_160/nn_264978/DE/Content/Infekt/EpidBull/Archiv/2007/07__07.html?__nnn=true. Cited 10 May 2010. In German. 29

  • Hanke CA, Otten JE, Berner R, Serr A, Splettstoesser W, von Schnakenburg C (2009) Ulceroglandular tularemia in a toddler in Germany after a mosquito bite. Eur J Pediatr 168:937–940

    PubMed  Google Scholar 

  • Hartelt K (2004) Epidemiologie Arthropoden-übertragener Infektionen in Baden-Württemberg. Doctoral thesis at the University of Hohenheim, Germany. In German

    Google Scholar 

  • Hartelt K, Oehme R, Frank H, Brockmann SO, Hassler D, Kimmig P (2004) Pathogens and symbionts in ticks: prevalence of Anaplasma phagocytophilum (Ehrlichia sp.), Wolbachia sp. Rickettsia sp. and Babesia sp. in Southern Germany. Int J Med Microbiol 293(Suppl 37):86–92

    PubMed  Google Scholar 

  • Hartelt K, Pluta S, Oehme R, Kimmig P (2008) Spread of ticks and tick-borne diseases in Germany due to global warming. Parasitol Res 103(Suppl 1):109–116

    Google Scholar 

  • Häselbarth K, Tenter AM, Brade V, Krieger G, Hunfeld KP (2007) First case of human babesiosis in Germany – clinical presentation and molecular characterisation of the pathogen. Int J Med Microbiol 297:197–204

    PubMed  Google Scholar 

  • Hauri AM, Hofstetter I, Seibold E, Kaysser P, Eckert J, Neubauer H, Splettstoesser WD (2010) Investigating an airborne tularemia outbreak, Germany. Emerg Infect Dis 16(2):238–243

    PubMed  Google Scholar 

  • Herwaldt BL, Caccio S, Gherlinzoni F, Aspöck H, Slemenda SB, Piccaluga PP, Martinelli G, Edelhofer R, Hollenstein U, Poletti G, Pampiglione S, Löschenberger K, Tura S, Pieniazek NJ (2003) Molecular characterization of a non-Babesia divergens organism causing zoonotic Babesiosis in Europe. Emerg Infect Dis 9(8):942–948

    PubMed  CAS  Google Scholar 

  • Hildebrandt A, Schmidt KH, Fingerle V, Wilske B, Straube E (2002) Prevalence of granulocytic ehrlichiae in Ixodes ricinus ticks in Middle Germany (Thuringia) detected by PCR and sequencing of a 16S ribosomal DNA fragment. FEMS Microbiol Lett 211:225–230

    PubMed  CAS  Google Scholar 

  • Hildebrandt A, Hunfeld KP, Baier M, Krumbholz A, Sachse S, Lorenzen T, Kiehntopf M, Fricke HJ, Straube E (2007) First confirmed autochthonous case of human Babesia microti infection in Europe. Eur J Clin Microbiol Infect Dis 26:595–601

    PubMed  CAS  Google Scholar 

  • Hildebrandt A, Krämer A, Sachse S, Straube E (2010) Detection of Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus ticks in a region of middle Germany (Thuringia). Ticks Tick-borne Dis 1:52–56

    PubMed  Google Scholar 

  • Hilpertshauser H, Deplazes P, Schnyder M, Gern L, Mathis A (2006) Babesia spp. identified by PCR in ticks collected from domestic and wild ruminants in southern Switzerland. Appl Environ Microbiol 72(10):6503–6507, 30

    PubMed  CAS  Google Scholar 

  • Homer MJ, Aguilar-Delfin I, Telford SR 3rd, Krause PJ, Persing DH (2000) Babesiosis. Clin Microbiol Rev 13:451–469

    PubMed  CAS  Google Scholar 

  • Hubalek Z, Sixl W, Halouzka J (1998) Francisella tularensis in Dermacentor reticulatus ticks from the Czech Republic and Austria. Wien Klin Wochenschr 110(24):909–910

    PubMed  CAS  Google Scholar 

  • Hunfeld KP, Brade V (1999) Prevalence of Antibodies against the human granulocytic ehrlichiosis agent in Lyme Borreliosis patients from Germany. Eur J Clin Microbiol Infect Dis 18:221–224

    PubMed  CAS  Google Scholar 

  • Hunfeld KP, Cinatl J, Tenter AM, Brade V (2002a) Granulocytic Ehrlichia, Babesia and spotted fever Rickettsia: not yet widely known tick-borne pathogens of considerable concern for humans at risk in Europe. Biotest Bull 6:321–344

    Google Scholar 

  • Hunfeld KP, Lambert A, Kampen H, Albert S, Epe C, Brade V, Tenter AM (2002b) Seroprevalence of Babesia infections in humans exposed to ticks in midwestern Germany. J Clin Microbiol 40(7):2431–2436

    PubMed  Google Scholar 

  • Hunfeld KP, Hildebrandt A, Gray JS (2008) Babesiosis: recent insights into and ancient disease. Int J Parasitol 38:1219–1237

    PubMed  CAS  Google Scholar 

  • Jado I, Oteo JA, Aldamiz M, Gil H, Escuerdo R, Ibarra V, Portu J, Portillo A, Lezaun MJ, Garcia-Amil C, Rodriguez-Moreno I, Anda P (2007) Rickettsia monacensis and human disease, Spain. Emerg Infect Dis 13(9):1405–1407

    PubMed  CAS  Google Scholar 

  • Jansen A, La Scola B, Raoult D, Lierz M, Wichmann O, Stark K, Schneider T (2008) Antibodies against Rickettsia spp. in hunters, Germany. Emerg Infect Dis 14(12):1961–1963

    PubMed  Google Scholar 

  • Jenzora A, Jansen A, Ranisch H, Lierz M, Wichmann O, Grunow R (2008) Seroprevalence study of Francisella tularensis among hunters in Germany. FEMS Immunol Med Microbiol 53:183–189

    PubMed  CAS  Google Scholar 

  • Kaysser P, Seibold E, Mätz-Rensing K, Pfeffer M, Essbauer S, Splettstoesser WD (2008) Re-emergence of tularemia in Germany: presence of Francisella tularensis in different rodent species in endemic areas. BMC Infect Dis 8:157

    PubMed  Google Scholar 

  • Kimmig P, Hassler D, Braun R (2000) Zecken - kleiner Stich mit bösen Folgen. Ehrenwirth (Hrsg), 2. Auflage. ISBN 3-431-04018-7. In German

    Google Scholar 

  • Kjemtrup AM, Conrad PA (2000) Human babesiosis: an emerging tick-borne disease. Int J Parasitol 30:1323–1337

    PubMed  CAS  Google Scholar 

  • Klasco R (2002) Colorado tick fever. Med Clin North Am 86:435–440

    PubMed  Google Scholar 

  • Kowalski J, Hopfenmüller W, Fingerle V, Malberg H, Eisenblätter M, Wagner J, Miksits K, Hahn H, Ignatius R (2006) Seroprevalence of human granulocytic anaplasmosis in Berlin/Brandenburg, Germany: an 8-year survey. Clin Microbiol Infect 12(9):924–927, 31

    PubMed  CAS  Google Scholar 

  • Krause PJ (2003) Babesiosis diagnosis and treatment. Vector Borne Zoonotic Dis 3:45–51

    PubMed  Google Scholar 

  • La Scola B, Raoult D (1997) Laboratory diagnosis of rickettsioses: current approaches to diagnosis of old and new rickettsial diseases. J Clin Microbiol 35(11):2715–2727

    PubMed  Google Scholar 

  • Lakos A (1997) Tick-borne lymphadenopathy - a new rickettsial disease? Lancet 350:1006

    PubMed  CAS  Google Scholar 

  • Leiby DA (2006) Babesiosis and blood transfusion: flying under the radar. Vox Sang 90:157–165

    PubMed  CAS  Google Scholar 

  • Liebisch A, Rahmann MS (1976) Zum Vorkommen und zur vektoriellen Bedeutung der Zecken Dermacentor marginatus (Sulzer, 1776) und Dermacentor reticulatus (Fabricius, 1794) in Deutschland. Tropenmed Parasitol 27:393–404, In German

    PubMed  CAS  Google Scholar 

  • Liz JS, Anderes L, Sumner JW, Massung RF, Gern L, Rutti B, Brossard M (2000) PCR detection of granulocytic ehrlichiae in Ixodes ricinus ticks and wild small mammals in western Switzerland. J Clin Microbiol 38(3):1002–1007

    PubMed  CAS  Google Scholar 

  • Liz JS, Summer JW, Pfister K, Brossard M (2002) PCR detection and serological evidence of granulocytic ehrlichial infection in roe deer (Capreolus capreolus) and chamois (Rupicapra rupicapra). J Clin Microbiol 40(3):892–897

    PubMed  Google Scholar 

  • Malkova D, Holubova J, Kolman JM, Marhoul Z, Hanzal F, Kulkova H, Markvart K, Simkova L (1980) Antibodies against some arboviruses in persons with various neuropathies. Acta Virol 24(4):298

    PubMed  CAS  Google Scholar 

  • Martinez JJ, Cossart P (2004) Early signaling events involved in the entry of Rickettsia conorii into mammalian cells. J Cell Sci 117:5097–5106

    PubMed  CAS  Google Scholar 

  • Maurin M, Bakken JS, Dumler JS (2003) Antibiotic susceptibilities of Anaplasma (Ehrlichia) phagocytophilum strains from various geographic areas in the United States. Antimicrob Agents Chemother 47:413–415

    PubMed  CAS  Google Scholar 

  • Mediannikov O, Matsumoto K, Samoylenko I, Drancourt M, Roux V, Rydkina E, Bavoust B, Tarasevich I, Brouqui P, Fournier PE (2008) Rickettsia raoultii sp. nov. a spotted fever group rickettsia associated with Dermacentor ticks in Europe and Russia. Int J Syst Evol Microbiol 58:1635–1639

    PubMed  CAS  Google Scholar 

  • Meer-Scherrer L, Adelson M, Mordechai E, Lottaz B, Tilton R (2004) Babesia microti infection in Europe. Curr Microbiol 48:435–437

    PubMed  CAS  Google Scholar 

  • Mehlhorn B, Mehlhorn H (2009) Zecken auf dem Vormarsch. Düsseldorf University Press, Düsseldorf

    Google Scholar 

  • Menn B, Lorentz S, Naucke TJ (2010) Imported and travelling dogs as carriers of canine vector-borne pathogens in Germany. Parasit Vectors 3:34

    PubMed  Google Scholar 

  • Nilsson K, Lindquist O, Pahlson C (1999) Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Lancet 354:1169–1173, 32

    PubMed  CAS  Google Scholar 

  • Nilsson K, Elfvig K, Pahlson C (2010) Rickettsia helvetica in patient with meningitis, Sweden, 2006. Emerg Infect Dis 16(3):490–492

    PubMed  CAS  Google Scholar 

  • Oehme R, Hartelt K, Backe H, Brockmann S, Kimmig P (2002) Foci of tick-borne diseases in Southwest Germany. Int J Med Microbiol 291(Suppl 33):22–29

    PubMed  Google Scholar 

  • Ortuno A, Quesada M, Lopez-Claessens S, Castella J, Sanfeliu I, Anton E, Segura-Porta F (2007) The role of wild boar (Sus scrofa) in the eco-epidemiology of R. slovaca in northeastern Spain. Vector Borne Zoonotic Dis 7(1):59–64

    PubMed  CAS  Google Scholar 

  • Parola P, Paddock CD, Raoult D (2005) Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clin Microbiol Rev 18(4):719–756

    PubMed  Google Scholar 

  • Parola P, Rovery C, Rolain JM, Brouqui P, Davoust B, Raoult D (2009) Rickettsia slovaca and R. raoultii in tick-borne rickettsioses. Emerg Infect Dis 15(7):1105–1108

    PubMed  Google Scholar 

  • Perlman SJ, Hunter MS, Zchori-Fein E (2006) The emerging diversity of Rickettsia. Proc Biol Sci 273:2097–2106

    PubMed  Google Scholar 

  • Petersen JM, Mead PS, Schriefer ME (2009) Francisella tularensis: an arthropod-borne pathogen. Vet Res 40(2):7

    PubMed  Google Scholar 

  • Petrovec M, Sixl W, Schweiger R, Mikulasek S, Elke L, Wüst G, Marth E, Strasek K, Stünzner D, Avsic-Zupanc T (2003) Infections of wild animals with Anaplasma phagocytophila in Austria and the Czech Republic. Ann NY Acad Sci 990:103–106

    PubMed  Google Scholar 

  • Pichon B, Kahl O, Hammer B, Gray JS (2006) Pathogens and host DNA in Ixodes ricinus nymphal ticks from a German forest. Vector Borne Zoonotic Dis 6(4):382–387

    PubMed  CAS  Google Scholar 

  • Pluta S, Tewald F, Hartelt K, Oehme R, Kimmig P, Mackenstedt U (2009) Rickettsia slovaca in Dermacentor marginatus ticks, Germany. Emerg Infect Dis 15(12):2077–2078

    PubMed  Google Scholar 

  • Pluta S, Hartelt K, Oehme R, Mackenstedt U, Kimmig P (2010) Prevalence of Coxiella burnetii and Rickettsia spp. in ticks and rodents in southern Germany. Ticks Tick-borne Dis 1(3):145–147. doi:10.1016/j.ttbdis.2010.04.001

    PubMed  Google Scholar 

  • Polin H, Hufnagl P, Haunschmid R, Gruber F, Ladurner G (2004) Molecular evidence of Anaplasma phagocytophilum in Ixodes ricinus ticks and wild animals in Austria. J Clin Microbiol 42(5):2285–2286

    PubMed  CAS  Google Scholar 

  • Porsch-Özcürümez M, Kischel N, Priebe H, Splettstösser W, Finke EJ, Grunow R (2004) Comparison of enzyme-linked immunosorbent assay, western blotting, microagglutination, indirect immunofluorescence assay, and flow cytometry for serological diagnosis of tularemia. Clin Diagn Lab Immunol 11(6):1008–1015, 33

    PubMed  Google Scholar 

  • Pusterla N, Leutenegger CM, Huder JB, Weber R, Braun U, Lutz H (1999) Evidence of the human granulocytic ehrlichiosis agent in Ixodes ricinus ticks in Switzerland. J Clin Microbiol 37(5):1332–1334

    PubMed  CAS  Google Scholar 

  • Raoult D, Roux V (1997) Rickettsioses as paradigms of new or emerging infectious diseases. Clin Microbiol Rev 10(4):694–719

    PubMed  CAS  Google Scholar 

  • Raoult D, Berbis PH, Roux V, Xu W, Maurin M (1997) A new tick-transmitted disease due to Rickettsia slovaca. Lancet 350:112–113

    PubMed  CAS  Google Scholar 

  • Rehacek J, Liebisch A, Urvölgyi J, Kovacova E (1977) Rickettsiae of the spotted fever isolated from Dermacentor marginatus ticks in South Germany. Zentralbl Bakteriol Orig A 239:275–281

    PubMed  CAS  Google Scholar 

  • Rehacek J, Urvölgyi J, Kocianova E, Jedlicka L (1992) Susceptibility of some species of rodents to rickettsiae. Folia Parasitol 39(3):265–284

    PubMed  CAS  Google Scholar 

  • Rehse-Küpper B, Casals J, Rehse E, Ackermann R (1976) Eyach – an arthropod-borne virus related to Colorado tick fever virus in the federal republic of Germany. Acta Virol 20:339–342

    PubMed  Google Scholar 

  • Rovery C, Brouqui P, Raoult D (2008) Questions on mediterranean spotted fever a century after its discovery. Emerg Infect Dis 14(9):1360–1367

    PubMed  Google Scholar 

  • Schmitt P, Splettstösser W, Porsch-Özcürümez M, Finke EJ, Grunow R (2005) A novel sreening ELISA and a confirmatory Western blot useful for diagnosis and epidemiological studies of tularemia. Epidemiol Infect 133:759–766

    PubMed  CAS  Google Scholar 

  • Sekeyova Z, Roux V, Xu W, Rehacek J, Raoult D (1998) Rickettsia slovaca sp. nov. a member of the spotted fever group rickettsiae. Int J Syst Bacteriol 48:1455–1462

    PubMed  Google Scholar 

  • Silaghi C, Gilles J, Höhle M, Fingerle V, Just FT, Pfister K (2008a) Anaplasma phagocytophilum infection in Ixodes ricinus, Bavaria, Germany. Emerg Infect Dis 14(6):972–974

    PubMed  CAS  Google Scholar 

  • Silaghi C, Gilles J, Höhle M, Pradel I, Just FT, Fingerle V, Küchenhoff H, Pfister K (2008b) Prevalence of spotted fever group rickettsiae in Ixodes ricinus (Acari: Ixodidae) in southern Germany. J Med Entomol 45(4):948–955

    PubMed  CAS  Google Scholar 

  • Simser JA, Palmer AT, Fingerle V, Wilske B, Kurtti TJ, Munderloh UG (2002) Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. Appl Environ Microbiol 68(9):4559–4566

    PubMed  CAS  Google Scholar 

  • Sixl W, Petrovec M, Marth E, Wüst G, Stünzner D, Schweiger R, Avsic-Zupanc T (2003) Investigation of Anaplasma phagocytophila infections in Ixodes ricinus and Dermacentor reticulatus ticks in Austria. Ann NY Acad Sci 990:94–97, 34

    PubMed  Google Scholar 

  • Skuballa JD, Petney T, Pfäffle M, Taraschewski H (2010) Molecular detection of Anaplasma phagocytophilum in the European hedgeog (Erinaceus europaeus) and its ticks. Vector Borne Zoonotic Dis 10(10):1055–1057, Epub 28 Apr 2010

    PubMed  Google Scholar 

  • Splettstoesser W (2008)Zur Häufung von Tularämie-Erkrankungen in Deutschland im Jahr 2007. Epidemiologisches Bulletin 4/2008. Available from http://www.rki.de/cln_160/nn_969736/DE/Content/Infekt/EpidBull/Archiv/2008/04/Tabelle.html?__nnn=true. Cited 10 May 2010. In German

  • Splettstoesser WD, Piechotowski I, Buckendahl A, Frangoulidis D, Kaysser P, Kratzer W, Kimmig P, Seibold E, Brockmann SO (2008) Tularemia in Germany: the tip of the iceberg? Epidemiol Infect 137:736–743

    PubMed  Google Scholar 

  • Strle F (2004) Human granulocytic ehrlichiosis in Europe. Int J Med Microbiol 293(Suppl 37):27–35

    PubMed  Google Scholar 

  • Taillardat-Bisch AV, Raoult D, Drancourt M (2003) RNA polymerase β-subunit-based phylogeny of Ehrlichia spp., Anaplasma spp., Neorickettsia spp. and Wolbachia pipientis. Int J Syst Evol Microbiol 53:455–458

    PubMed  CAS  Google Scholar 

  • Vogl UM, Presterl E, Stanek G, Ramharter M, Gattringer KB, Graninger W (2010) First described case of human granulocytic anaplasmosis in a patient in eastern Austria. Wien Klin Wochenschr 160(3–4):91–93

    Google Scholar 

  • von Loewenich FD, Baumgarten BU, Schröppel K, Geißdörfer W, Röllinghoff M, Bogdan C (2003) High density of ankA sequences of Anaplasma phagocytophilum among Ixodes ricinus ticks in Germany. J Clin Microbiol 41(11):5033–5040

    Google Scholar 

  • Walder G, Falkensammer B, Aigner J, Tiwald G, Dierich MP, Würzer R, Lechleitner P (2003a) First documented case of human granulocytic ehrlichiosis in Austria. Wien Klin Wochenschr 115(7–8):263–266

    PubMed  Google Scholar 

  • Walder G, Tiwald G, Dierich MP, Würzner R (2003b) Serological evidence for human granulocytic ehrlichiosis in western Austria. Eur J Clin Microbiol Infect Dis 22:543–547

    PubMed  CAS  Google Scholar 

  • Walder G, Fuchs D, Sarcletti M, Berek K, Falkensammer B, Huber K, Petrovec M, Dierich MP, Würzner R (2006) Human granulocytic anaplasmosis in Austria: epidemiological, clinical, and laboratory findings in five consecutive patients from Tyrol, Austria. Int J Med Microbiol 296(Suppl 1):297–301

    PubMed  Google Scholar 

  • Wang TJ, Liang MH, Sangha O, Phillips CB, Lew RA, Wright EA, Berardi V, Fossel AH, Shadick NA (2000) Coexposure to Borrelia burgdorferi and Babesia microti does not worsen the long-term outcome of Lyme disease. Clin Infect Dis 31:1149–1154

    PubMed  CAS  Google Scholar 

  • Weber R, Pusterla N, Loy M, Leutenegger CM, Schär G, Baumann D, Wolfensberger C, Lutz H (2000) Serologische und klinische Daten weisen auf das endemische Vorkommen der humanen granulozytären Ehrlichiose in der Nordostschweiz hin. Schweiz Med Wochenschr 130:1462–1470, In German

    PubMed  CAS  Google Scholar 

  • Weinert LA, Werren JH, Aebi A, Stone GN, Jiggins FM (2009) Evolution and diversity of Rickettsia bacteria. BMC Biol 7:6

    PubMed  Google Scholar 

  • Wicki R, Sauter P, Mettler C, Natsch A, Enzler T, Pusterla N, Kuhnert P, Egli G, Bernasconi M, Lienhard R, Lutz H, Leutenegger CM (2000) Swiss army survey in Switzerland to determine the prevalence of Francisella tularensis, members of the Ehrlichia phagocytophila genogroup, Borrelia burgdorferi sensu lato, and tick-borne encephalitis virus in ticks. Eur J Clin Microbiol Infect Dis 19:427–432

    PubMed  CAS  Google Scholar 

  • Wölfel R, Terzioglu R, Kiessling J, Wilhelm S, Essbauer S, Pfeffer M, Dobler G (2006) Rickettsia spp. in Ixodes ricinus ticks in Bavaria, Germany. Ann NY Acad Sci 1078:509–511

    PubMed  Google Scholar 

  • Zhan L, Cao W, Chu C, Jiang B, Zhang F, Liu W, Dumler JS, Wu X, Zuo S, Zhang P, Huang H, Zhao Q, Jia N, Yang H, Richardus JH, Habbema JDF (2009) Tick-borne agents in rodents, China, 2004-2009. Emerg Infect Dis 15(12):1904–1908

    PubMed  Google Scholar 

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Acknowledgements

We thank Susanne Schex and Sandra Essbauer from the Bundeswehr Institute of Microbiology for their information about Rickettsia spp. in rodents, and Peter Otto from the Friedrich-Löffler-Institute in Jena for information about F. tularensis in hare.

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Correspondence to Ute Mackenstedt .

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Pluta, S., Hartelt, K., Oehme, R., Kimmig, P., Mackenstedt, U. (2011). What Else Besides TBE and Borreliosis? Tick-Transmitted Pathogens in Germany and Beyond. In: Mehlhorn, H. (eds) Progress in Parasitology. Parasitology Research Monographs, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21396-0_16

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