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The Dynamic of Electroporation in Dilute Cell Suspension: A Numerical and Experimental Study

  • Conference paper
V Latin American Congress on Biomedical Engineering CLAIB 2011 May 16-21, 2011, Habana, Cuba

Part of the book series: IFMBE Proceedings ((IFMBE,volume 33))

  • 124 Accesses

Abstract

The electroporation is utilized in the gene therapy, DNA vaccination protocols, cancer treatment and introduce substances into cells. Nowadays, the experimental results are not completely understood and explained by a theory or mathematical model. This work proposed the compatibility between experimental and numerical results. The assymptotic model presented error less than 1%. The simulation provides information about the alteration of transmembrane potential and membrane conductance during electroporation pulse. The simulation of rest potential effect does not cause the electroporation asymmetry described experimentally.

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Authors and Affiliations

  1. Instituto de Engenharia Biomédica, Departamento de Engenharia Elétrica, CTC, UFSC, Florianópolis, SC, Brasil

    D. O. H. Suzuki & J. L. B. Marques

  2. Grupo de Engenharia Biomédica, Departamento de Engenharia Elétrica, CCT, UDESC, Joinville, SC, Brasil

    A. Ramos

  3. Departamento de Bioquímica, CCB, UFSC, Florianópolis, SC, Brasil

    L. H. Cazarolli & F. R. M. B. Silva

Authors
  1. D. O. H. Suzuki
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  2. A. Ramos
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  3. L. H. Cazarolli
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  4. F. R. M. B. Silva
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  5. J. L. B. Marques
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Corresponding author

Correspondence to D. O. H. Suzuki .

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Editors and Affiliations

  1. Instituto Central de Investigación Digit, Calle 231 # 22014 entre 220 y 224, Fontanar, La Habana, CP, 19250, Cuba

    José Folgueras Méndez

  2. Cubanacán, Playa, Centro de Neurociencias de Cuba, Ave 25 No. 15202 esq. 158, La Habana, CP, 11600, Cuba

    Tania Y. Aznielle Rodríguez

  3. , Departamento de Medicina Nuclear, Instituto de Oncología y Radiobiología, Calle 29 esq. E, Vedado, Plaza, La Habana, CP, 10400, Cuba

    Carlos F. Calderón Marín

  4. Vedado, Plaza de la Revolución, Escuela Nacional de Salud Pública, Calle 18 #162 Apto. 4 e; 13 y 15,, Habana, CP, 10400, Cuba

    Susana Beatriz Llanusa Ruiz

  5. Hospital Nacional de Rehabilitación Juli, Ave 243 # 19815, Fontanar, Boyeros, La Habana, CP, 19250, Cuba

    Jorge Castro Medina

  6. , Infomed, Centro Nacional de Información de Cienci, Calle 27 No. 110 e/ M y N, Plaza de la Revolución, La Habana, CP, 10400, Cuba

    Haddid Vega Vázquez

  7. International Centre for Neurological Re, Ave 25 #15805 e/ 158 & 160, Cubanacan, Playa, La Habana, CP, 10300, Cuba

    Maylen Carballo Barreda

  8. International Centre for Neurological Re, Ave 25 #15805 e/ 158 & 160, Cubanacan, Playa, La Habana, CP, 10301, Cuba

    Rafael Rodríguez Rojas

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Suzuki, D.O.H., Ramos, A., Cazarolli, L.H., Silva, F.R.M.B., Marques, J.L.B. (2013). The Dynamic of Electroporation in Dilute Cell Suspension: A Numerical and Experimental Study. In: Folgueras Méndez, J., et al. V Latin American Congress on Biomedical Engineering CLAIB 2011 May 16-21, 2011, Habana, Cuba. IFMBE Proceedings, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21198-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-21198-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-21197-3

  • Online ISBN: 978-3-642-21198-0

  • eBook Packages: EngineeringEngineering (R0)

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