Zusammenfassung
Benzodiazepine werden ihrer anxiolytischen und sedierenden Wirkung wegen häufig zur Prämedikation vor einer Narkose eingesetzt, eignen sich aber auch als Hypnotika für diagnostische Eingriffe und als hypnotische Komponente im Rahmen einer balancierten Anästhesie. Antikonvulsive Wirkungen der Benzodiazepine werden für die Anfallsprophylaxe, muskelrelaxierende Eigenschaften zur Therapie von muskulären Verspannungen genutzt.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Bauer C, Kreuer S, Ketter R, Grundmann U, Wilhelm W (2007) Remifentanil-Propofol- versus Fentanyl-Midazolam-Kombination bei intrakraniellen Eingriffen. Anaesthesist 56: 128–132
Dahmani S, Brasher C, Stany I et al. (2010) Premedication with clonidine is superior to benzodiazepines. A meta analysis of published studies. Acta Anaesthesiol Scand 54: 397–402
Deutsche Gesellschaft für Anästhesie und Intensivmedizin (DGAI), Deutsche interdisziplinäre Vereinigung für Intensivmedizin DIVI (2010) Analgesie, Sedierung und Delirmanagement in der Intensivmedizin – Langfassung. http://www.awmf.org/uploads/tx_szleitlinien/001-012l.pdf
Ely EW, Truman B, Shintani A et al. (2003) Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 289: 2983–2991
Gascon E, Klauser P, Kiss JZ, Vutskits L (2007) Potentially toxic effects of anaesthetics on the developing central nervous system. Eur J Anaesthesiol 24: 213–224
Kilpatrick GJ, McIntyre MS, Cox RF et al. (2007) CNS 7056: a novel ultrashort-acting Benzodiazepine. Anesthesiology 107: 60–66
Lonergan E, Luxenberg J, Areosa Sastre A, Wyller TB (2009) Benzodiazepines for delirium. Cochrane Database Syst Rev 1: CD006379
Martin J, Franck M, Sigel S, Weiss M, Spies CD (2007) Changes in sedation management in German intensive care units between 2002 and 2006: a national follow up survey. Crit Care 11: R124
Muellejans B, Matthey T, Scholpp J, Schill M (2006) Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial. Crit Care 10: R91
Ohta N, Ohashi Y, Takayama C, Mashimo T, Fujino Y (2011) Midazolam Suppresses Maturation of Murine Dendritic Cells and Priming of Lipopolysaccharide-induced T Helper 1-type Immune Response Anesthesiology. 114: 355–362
Pandharipande P, Shintani A, Peterson J et al. (2006) Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104: 21–26
Park G, Lane M, Rogers S, Bassett P (2007) A comparison of hypnotic and analgesic based sedation in a general intensive care unit. Br J Anaesth 98: 76–82
Peeters MY, Prins SA, Knibbe CA et al. (2006) Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery. Anesthesiology 105: 1135–1146
Ricci L, Valoti M, Sgaragli G, Frosini M (2007) Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices. Eur J Pharmacol 561: 80–84
Riker RR, Shehabi Y, Bokesch PM et al. (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 301: 489–499
Riphaus A, Wehrmann T, Weber B et al. ( 2008) S3-Leitlinie »Sedierung in der gastrointestinalen Endoskopie« 2008. Z Gastroenterol. 46: 1298–1330
Rogers WK, McDowell TS (2010) Remimazolam, a short-acting GABA(A) receptor agonist for intravenous sedation and/or anesthesia in day-case surgical and non-surgical procedures. IDrugs. 13:929–937
Roquilly A, Josien R. Asehnoune K (2011) Midazolam Impairs Immune Functions: It‘s Time to Take Care of Dendritic Cells. Anesthesiology. 114: 237–238
Sneyd JR, Rigby-Jones AE (2010) New drugs and technologies, intravenous anaesthesia is on the move (again).Br J Anaesth. 105: 246–254
Swart EL, Zuideveld KP, de Jongh J et al. (2004) Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients. Br J Clin Pharmacol 57:135–145
Young C, Knudsen N, Hilton A, Reves JG (2000) Sedation in the intensive care unit. Crit Care Med 28: 854–866
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Busley, R. (2012). Benzodiazepine. In: Rossaint, R., Werner, C., Zwißler, B. (eds) Die Anästhesiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21125-6_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-21125-6_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-21124-9
Online ISBN: 978-3-642-21125-6
eBook Packages: Medicine (German Language)