Abstract
Surface enhanced resonance Raman scattering (SERRS) is an analytical technique with several advantages over competitive techniques in terms of improved sensitivity and selectivity. We have made great progress in the development of SERRS as a quantitative analytical method, in particular for the detection of DNA. However, one of the main advantages over fluorescence and other optical detection techniques is the ability to multiplex.
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References
Fleischmann M, Hendra PJ, McQuillan AJ (1974) Raman spectra of pyridine adsorbed at a silver electrode. Chem Phys Lett 26(2):163–166
Jeanmarie DL, Van Duyne RP (1977) Surface Raman spectroelectrochemistry: part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode. J Electroanal Chem 84:1–20
Hildebrandt P, Stockburger M (1984) Surface-enhanced resonance Raman spectroscopy of Rhodamine 6G adsorbed on colloidal silver. J Phys Chem 88(24):5935–5944
Emory SR, Nie S (1997) Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275:1102–1106
Kneipp K, Wang Y, Kneipp H, Perelman LT, Itzkan I, Dasari RR, Feld M (1997) Single molecule detection using surface-enhanced Raman scattering (SERS). Phys Rev Lett 78:1667–1670
Munro CH, Smith WE, White PC (1995) Qualitative and semi-quantitative trace analysis of acidic monoazo dyes by surface enhanced resonance Raman scattering. Analyst 120:993–1003
Lee PC, Meisel D (1982) Adsorption and surface-enhanced Raman of silver and gold sols. J Phys Chem 86:3391–3395
Li H, Ying L, Green JJ, Balasubramanian S, Klenerman D (2003) Ultrasensitive coincidence fluorescence detection of single DNA molecules. Anal Chem 75:1664–1670
Rodger C, Smith WE, Dent D, Edmondson J (1996) Surface-enhanced resonance-Raman scattering: an informative probe of surfaces. J Chem Soc Dalton 5:791–799
Isola NR, Stokes DL, Vo-Dinh T (1998) Surface enhanced Raman gene probe for HIV detection. Anal Chem 70:1352–1356
Graham D, Brown R, Smith WE (2001) SERRS detection of PNA and DNA labelled with a specifically designed benzotriazole azo dye. Chem Commun 11:1002–1003
Brown R, Smith WE, Graham D (2003) Synthesis of a benzotriazole azo dye phosphoramidite for labeling of oligonucleotides. Tetrahedron Lett 44(7):1339–1342
Albrecht MG, Creighton JA (1977) Anomalously intense Raman spectra of pyridine at a silver electrode. J Am Chem Soc 99:5215–5217
Stacy AM, Van Duyne RP (1983) Surface enhanced Raman and resonance Raman spectroscopy in a non-aqueous electrochemical environment: tris (2,2′-bipyridine)ruthenium(II) adsorbed on silver from acetonitrile. Chem Phys Lett 102:365–370
Campion A, Kambhampati P (1998) Surface-enhanced Raman scattering. Chem Soc Rev 4:241–250
Schultz G, Janik-Czachor M, Van Duyne RP (1981) Surface enhanced Raman spectroscopy: a re-examination of the role of surface roughness and electrochemical anodization. Surf Sci 104:419–434
Jiang X, Campion A (1987) Chemical effects in surface-enhanced Raman scattering: pyridine chemisorbed on silver adatoms on Rh (100). Chem Phys Lett 140(1):95–100
Creighton JA, Blatchford CG, Albrecht MG (1979) Plasma resonance enhancement of Raman scattering by pyridine adsorbed on silver or gold sol particles of size comparable to the excitation wavelength. J Chem Soc Faraday Trans II 75:790–798
Blatchford CG, Campbell JR, Creighton JA (1982) Plasma resonance – enhanced Raman scattering by absorbates on gold colloids: the effects of aggregation. Surf Sci 120(2):435–455
Kneipp K, Dasari RR, Wang Y (1994) Near-infrared surface-enhanced Raman scattering (NIR SERS) on colloidal silver and gold. Appl Spectrosc 48(8):951–955
Grabar KC, Freeman RG, Hommer MB, Natan MJ (1995) Preparation and characterization of au colloid monolayers. Anal Chem 67(4):735–743
Grabar KC, Brown KR, Keating CD, Stranick SJ, Tang S-L, Natan MJ (1997) Nanoscale characterization of gold colloid monolayers: a comparison of four techniques. Anal Chem 69(3):471–477
Curtis CC, Duff DG, Edwards PP, Jefferson DA, Johnson BFG, Kirkland AI, Wallace AS (1988) Preparation and structural characterization of an unprotected copper sol. J Phys Chem 92:2270–2275
Huang HH, Yan FQ, Kek YM, Chew CH, Xu GQ, Ji W, Oh PS, Tang SH (1997) Synthesis characterization, and nonlinear optical properties of copper nanoparticles. Langmuir 13:172–175
Volkan M, Stokes DL, Vo-Dinh T (2000) Surface-enhanced Raman of dopamine and neurotransmitters using sol–gel substrates and polymer-coated fiber-optic probes. Appl Spectrosc 54(12):1842–1848
Laserna JJ, Campiglia AD, Winefordner JD (1988) Surface-enhanced Raman spectrometry on a silver-coated filter paper substrate. Anal Chim Acta 208:21–30
Ruperez A, Laserna JJ (1994) Surface-enhanced Raman spectrometry on a silver substrate prepared by the nitric acid etching method. Anal Chim Acta 291:147–153
Bello JM, Stokes DL, Vo-Dinh T (1989) Titanium dioxide based substrate for optical monitors in surface-enhanced Raman scattering analysis. Anal Chem 61:1779–1783
Walsh RJ, Chumanov G (2001) Silver coated porous alumina as a new substrate for surface-enhanced Raman scattering. Appl Spectrosc 55(12):1695–1700
Bell SEJ, Spencer SJ (2001) Disposable, stable media for reproducible surface-enhanced Raman spectroscopy. Analyst 126:1–3
Bharathi S, Fishelson N, Lev O (1999) Direct synthesis and characterization of gold and other noble metal nanodispersions in sol–gel-derived organically modified silicates. Langmuir 15:1929–1937
Saegmueller B, Brehm G, Schneider S (2000) In situ generated photolytic silver in a gelatin matrix: an approach for high-throughput SERS spectroscopy applying microtiter plates. Appl Spectrosc 54(12):1849–1856
Perez R, Ruperez A, Laserna JJ (1998) Evaluation of silver substrates for surface-enhanced Raman detection of drugs banned in sport practices. Anal Chim Acta 376:255–263
Norrod KL, Sudnik LM, Rousell D, Rowlen KL (1997) Quantitative comparison of five SERS substrates: sensitivity and limit of detection. Appl Spectrosc 51(7):994–1001
McKenzie F, Faulds K, Graham D (2010) Mixed metal nanoparticle assembly and the effect on surface-enhanced Raman scattering. Nanoscale 2:78–80
Stokes RJ, Macaskill A, Lundahl PJ, Smith WE, Faulds K, Graham D (2007) Quantitative enhanced Raman scattering of labelled DNA from gold and silver nanoparticles. Small 3(9):1593–1604
Munro CH, Smith WE, Garner M, Clarkson J, White PC (1995) Characterization of the surface of a citrate-reduced colloid optimized for use as a substrate for surface-enhanced resonance Raman scattering. Langmuir 11:3712–3720
Chow MK, Zukoski CF (1994) Gold sol formation mechanisms: role of colloidal stability. J Colloid Interface Sci 165:97–109
Biggs S, Mulvaney P, Zukoski CF, Greiser F (1994) Study of anion adsorption at the gold-aqueous solution interface by atomic force microscopy. J Am Chem Soc 116:9150–9157
MacAskill A, Chernonosov A, Koval V, Lukyanets E, Fedorova O, Smith WE, Faulds K, Graham D (2007) Quantitative surface-enhanced resonance Raman scattering of phthalocyanine labelled oligonucleotides. Nucleic Acids Res 35:e42
Faulds K, Fruk L, Robson DC, Thompson DG, Enright A, Smith WE, Graham D (2006) A new approach for DNA detection by SERRS. Faraday Discuss 132:261–268
Faulds K, Smith WE, Graham D (2004) Evaluation of surface enhanced resonance Raman scattering (SERRS) for highly sensitive and quantitative DNA analysis. Anal Chem 76:412–417
Basu HS, Marton LJ (1987) The interaction of spermine and pentamines with DNA. Biochem J 244:243–246
Graham D, Smith WE, Linacre AMT, Munro CH, Watson ND, White PC (1997) Selective detection of deoxyribonucleic acid at ultra low concentrations by SERRS. Anal Chem 69(22):4703–4707
Faulds K, MacKenzie F, Graham D (2007) Evaluation of the number of modified bases required for quantitative SERRS from labelled DNA. Analyst 132:1100–1102
Faulds K, Barbagallo RP, Keer JT, Smith WE, Graham D (2004) SERRS as a more sensitive technique for the detection of labelled oligonucleotides compared to fluorescence. Analyst 129:567–568
Graham D, Mallinder BJ, Smith WE (2000) Surface-enhanced resonance Raman scattering as a novel method of DNA discrimination. Angew Chem Int Ed 39(6):1061–1063
Frances T, Docherty FT, Clark M, McNay G, Graham D, Smith WE (2004) Multiple labelled nanoparticles for bio detection. Faraday Discuss 126:281–288
Faulds K, Mackenzie F, Smith WE, Graham D (2007) Quantitative simultaneous multianalyte detection of DNA by dual- wavelength surface-enhanced resonance Raman scattering. Angew Chem Int Ed 46(11):1829–1831
Brereton R (2003) Chemometrics: data analysis for the laboratory and chemical plant. Wiley, Chichester
Manly BFJ (1994) Multivariate statistical methods: a primer. Chapman & Hall/CRC Press, New York
Faulds K, Jarvis R, Smith WE, Graham D, Goodacre R (2008) Multiplexed detection of six labelled oligonucleotides using surface enhanced resonance Raman scattering (SERRS). Analyst 2008(133):1505–1512
Graham D, Mallinder BJ, Whitcombe D, Smith WE (2001) Surface enhanced resonance Raman scattering (SERRS) – a first example of its use in multiplex genotyping. ChemPhysChem 2(12):746–748
Graham D, Mallinder DJ, Whitcombe D, Watson ND, Smith WE (2002) Single multiplex genotyping by surface-enhanced resonance Raman scattering. Anal Chem 74:1069–1074
MacAskill A, Crawford D, Graham D, Faulds K (2009) DNA sequence detection using surface enhanced resonance Raman spectroscopy in a homogeneous multiplexed assay. Anal Chem 81(19):8134–8140
Allain LR, Vo-Dinh T (2002) Surface-enhanced Raman scattering detection of the breast cancer susceptibility gene BRCA1 using a silver-coated microarray platform. Anal Chim Acta 469:149–154
Mustafa C, Stokes D, Allain LR, Vo-Dinh T (2003) Surface-enhanced Raman scattering substrate based on a self-assembled monolayer for use in gene diagnostics. Anal Chem 75:6196–6201
Wang H-N, Vo-Dinh T (2009) Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes. Nanotechnology 20:065101 (6 pp)
Lowe AJ, Huh YS, Strckland AD, Erickson D, Batt CA (2010) Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction coupled surface enhanced Raman spectroscopy. Anal Chem 82(13):5810–5814
Cao YC, Jin R, Mirkin CA (2002) Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. Science 297(5586):1536–1540
Sun L, Yu C, Irudayaraj J (2007) Surface-enhanced Raman scattering based nonfluorescent probe for multiplex DNA detection. Anal Chem 79:3981–3988
Sun L, Yu C, Irudayaraj J (2008) Raman multiplexers for alternative gene splicing. Anal Chem 80:3342–3349
Sun L, Irudayaraj J (2009) PCR-free quantification of multiple splice variants in a cancer gene by surface-enhanced Raman spectroscopy. J Phys Chem B 113:14021–14025
Graham D, Thompson DG, Smith WE, Faulds K (2008) Control of enhanced Raman scattering using a DNA-based assembly process of dye-coded nanoparticles. Nat Nanotechnol 3(9):548–551
Qian X, Peng X-H, Ansari DO, Yin-Goen Q, Chen GZ, Shin DM, Yang L, Young AN, Wang MD, Nie S (2008) In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nature Biotechnol 26:83–90
Keren S, Zavaleta C, Cheng Z, de la Zerda A, Gheysens O, Ghambhir SS (2008) Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proc Natl Acad Sci USA 105:5844–5849
Zavaleta CL, Smith BR, Walton I, Doering W, Davis G, Shojaei B, Natan MJ, Ghambhir SS (2009) Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. Proc Natl Acad Sci USA 106(32):13511–13516
Stone N, Faulds K, Graham D, Matousek P (2010) Deep-SERRS: demonstration of deep Raman spectroscopy for non-invasive detection of conjugated SERRS nanoparticles buried within 25 mm of mammalian tissue. Anal Chem 82:3969–3973
Matschulat A, Drescher D, Kneipp J (2010) Surface-enhanced Raman scattering hybrid nanoprobe multiplexing and imaging in biological systems. ACS Nano 4(6):3259–3269
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Faulds, K. (2012). Multiplexed SERS for DNA Detection. In: Kumar, C.S.S.R. (eds) Raman Spectroscopy for Nanomaterials Characterization. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20620-7_13
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DOI: https://doi.org/10.1007/978-3-642-20620-7_13
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