Abstract
In order to better understand the mechanisms of gas transport during High Frequency Oscillatory Ventilation (HFOV) Magnetic Resonance Imaging (MRI) with contrast gases and numerical flow simulations based on Computational Fluid Dynamics(CFD) methods are performed.
Validation of these new techniques is conducted by comparing the results obtained with simplified models of the trachea and a first lung bifurcation as well as in a cast model of the upper central airways with results achieved from conventional fluid mechanical measurement techniques like e.g. Laser Doppler Anemometry (LDA). Further it is demonstrated that MRI of experimental HFOV is feasible and that Hyperpolarized 3He allows for imaging the gas re-distribution inside the lung. Finally, numerical results of oscillatory flow in a 3rd generation model of the lung as well as the impact of endotracheal tubes on the flow regime development in a trachea model are presented
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Amor, N., Zanker, P.P., Blumler, P., Meise, F.M., Schreiber, L.M., Scholz, A., Schmiedeskamp, J., Spiess, H.W., Munnemann, K.: Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system. J. Magn. Reson 201, 93–99 (2009)
Chan, K.P., Stewart, T.E.: Clinical use of high-frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome. Crit. Care Med. 33, S170–S174 (2005)
Chan, K.P., Stewart, T.E., Mehta, S.: High-frequency oscillatory ventilation for adult patients with ARDS. Chest 131, 1907–1916 (2007)
Chang, H.K.: Mechanisms of gas transport during ventilation by high-frequency oscillation. J. Appl. Physiol. 56, 553–563 (1984)
Downar, J., Mehta, S.: Bench-to-bedside review: high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit. Care 10, 240 (2006)
Fain, S.B., Korosec, F.R., Holmes, J.H., O’Halloran, R., Sorkness, R.L., Grist, T.M.: Functional lung imaging using hyperpolarized gas MRI. J. Magn. Reson Imaging 25, 910–923 (2007)
Gast, K.K., Wolf, U.: Functional 3He-MRI of the lungs. Radiologe 49, 720–731 (2009)
Hager, D.N., Fessler, H.E., Kaczka, D.W., Shanholtz, C.B., Fuld, M.K., Simon, B.A., Brower, R.G.: Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit. Care Med. 35, 1522–1529 (2007)
Heraty, K.B., Laffey, J.G., Quinlan, N.J.: Fluid dynamics of gas exchange in high-frequency oscillatory ventilation: in vitro investigations in idealized and anatomically realistic airway bifurcation models. Ann. Biomed. Eng. 36, 1856–1869 (2008)
Hopkins, S.R., Levin, D.L., Emami, K., Kadlecek, S., Yu, J., Ishii, M., Rizi, R.R.: Advances in magnetic resonance imaging of lung physiology. J. Appl. Physiol. 102, 1244–1254 (2007)
Imai, Y., Nakagawa, S., Ito, Y., Kawano, T., Slutsky, A.S., Miyasaka, K.: Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation. J. Appl. Physiol. 91, 1836–1844 (2001)
Imai, Y., Slutsky, A.S.: High-frequency oscillatory ventilation and ventilator-induced lung injury. Crit. Care Med. 134, S129–S134 (2005)
Kalthoff, D.: Entwicklung von Methoden zur Untersuchung von Strmungsverhltnisse von Kontrastgasen mittels Magnetresonanz-Tomographie. Diploma Thesis, Department of Physics, Mainz University (2007)
Knopp, T., Zhang, X., Kessler, R., et al.: Enhancement of an industrial finite-volume code for large-eddy-type simulation of incompressible high Reynolds number flow using nearwall modelling. In: Comput.Methods Appl. Mech. Eng. (2009) (in Press)
Krenkel, L., Wagner, C., et al.: Protective artificial lung ventilation: investigation of the air flow in a generic model of the lung. Accepted for Notes on Numerical Fluid Mechanics and Multidisciplinary Design. Springer, Heidelberg (2009)
Lenz, C.: Rekonstruktion von Luftwegen in der Lunge aus medizinischen Bilddaten. Master Thesis, Universitt Leipzig (2009)
Pennecot, J., Krenkel, L., Wagner, C.: An Automated Reconstruction of the Lungs for CFD Simulations, Venice, Italy. In: ECCOMAS 2008 (2008)
Pillow, J.J.: High-frequency oscillatory ventilation: mechanisms of gas exchange and lung mechanics. Crit. Care Med. 33, 135–141 (2005)
Rocco, P.R.M., Zin, W.A.: Modelling the mechanical effects of tracheal tubes in normal subjects. Eur. Respir. J. 8, 121–126 (1995)
Rochefort de, L., Vial, L., Fodil, R., Maitre, X., Louis, B., Isabey, D., Caillibotte, G., Thiriet, M., Bittoun, J., Durand, E., Sbirlea-Apiou, G.: In vitro validation of computational fluid dynamic simulation in human proximal airways with hyperpolarized 3He magnetic resonance phase-contrast velocimetry. J. Appl. Physiol. 102, 2012–2023 (2007)
Scholz, A.W., Wolf, U., Fabel, M., Weiler, N., Heussel, C.P., Eberle, B., David, M., Schreiber, W.G.: Comparison of magnetic resonance imaging of inhaled SF6 with respiratory gas analysis. Magn. Reson Imaging 27, 549–556 (2009)
Schreiber, W.G., Markstaller, K., Weiler, N., Eberle, B., Laukemper-Ostendorf, S., Scholz, A., Burger, K., Thelen, M., Kauczor, H.U.: 19F-MRT of pulmonary ventilation in the breath-hold technic using SF6 gas. Rofo 172, 500–503 (2000)
Schreiber, W.G., Eberle, B., Laukemper-Ostendorf, S., Markstaller, K., Weiler, N., Scholz, A., Burger, K., Heussel, C.P., Thelen, M., Kauczor, H.U.: Dynamic (19)F-MRI of pulmonary ventilation using sulfur hexafluoride (SF(6)) gas. Magn. Reson. Med. 45, 605–613 (2001)
Terekhov, M., Rivoire, J., Scholz, A., Wolf, U., Karpuk, S., Salhi, Z., Koebrich, R., David, M., Schreiber, L.M.: Measurement of gas transport kinetics in high-frequency oscillatory ventilation (HFOV) of the lung using hyperpolarized 3He MRI. J. Magn. Reson. Imaging (2009) (in review)
Wolf, U., Scholz, A., Heussel, C.P., Markstaller, K., Schreiber, W.G.: Subsecond fluorine-19 MRI of the lung. Magn. Reson. Med. 55, 948–951 (2006)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Scholz, AW.K. et al. (2011). Magnetic Resonance Imaging and Computational Fluid Dynamics of High Frequency Oscillatory Ventilation (HFOV). In: Klaas, M., Koch, E., Schröder, W. (eds) Fundamental Medical and Engineering Investigations on Protective Artificial Respiration. Notes on Numerical Fluid Mechanics and Multidisciplinary Design, vol 116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20326-8_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-20326-8_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-20325-1
Online ISBN: 978-3-642-20326-8
eBook Packages: EngineeringEngineering (R0)