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Exposure, Uptake, and Barriers

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Nanoethics and Nanotoxicology

Abstract

The nanotechnologies market is booming, e.g., in the food industry (powder additives, etc.) and in medical applications (drug delivery, prosthetics, diagnostic imaging, etc.), but also in other industrial sectors, such as sports, construction, cosmetics, and so on. In this context, with an exponential increase in the number of current and future applications, it is particularly important to evaluate the problem of unintentional (i.e., non-medical) exposure to manufactured nanoparticles (so excluding nanoparticles found naturally in the environment). In this chapter, we begin by discussing the various parameters that must be taken into account in any serious assessment of exposure to man-made nanoparticles. We then list the potential routes by which nanoparticles might enter into the organism, and outline the mechanisms whereby they could get past the different biological barriers. Finally, we describe the biodistribution of nanoparticles in the organism and the way they are eliminated.

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Authors and Affiliations

  1. Laboratoire des réponses moléculaires et cellulaires aux xénobiotiques (RMCX) Unité de biologie fonctionnelle et adaptative (BFA), EAC CNRS 4413 Case 7073, Université Paris Diderot-Paris 7, 5 rue Thomas Mann, 75205, Paris Cedex 13, France

    Armelle Baeza-Squiban

  2. Institut National de la Santé et de la Recherche Médicale (INSERM U955), Groupe Hospitalier Universitaire Albert Chenevier–Henri Mondor, 51, avenue du Maréchal-de-Lattre-de- Tassigny, 94010, Créteil Cedex, France

    Sophie Lanone

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  1. Armelle Baeza-Squiban
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Correspondence to Armelle Baeza-Squiban .

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Editors and Affiliations

  1. , Département Sciences des Matériaux, Université d'Evry, Rue du père Jarlan, Evry Cedex, 91025, France

    Philippe Houdy

  2. Club NanoMicroTechnologie, Vice Président du, rue de l’Avenir 8, Villebon sur Yvette, 91140, France

    Marcel Lahmani

  3. , Laboratoire des RMCX, Université Paris Diderot-Paris 7, rue Marie-Andrée Lagroua Weill-Hall 4, Paris cédex, 75205, France

    Francelyne Marano

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Baeza-Squiban, A., Lanone, S. (2011). Exposure, Uptake, and Barriers. In: Houdy, P., Lahmani, M., Marano, F. (eds) Nanoethics and Nanotoxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20177-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-20177-6_2

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