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Pattern Formation in Regenerating Tissues

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Pattern Formation in Morphogenesis

Part of the book series: Springer Proceedings in Mathematics ((PROM,volume 15))

Abstract

To understand the concept of pattern formation and its role in regeneration, the basic differences between repair and regeneration needs to be explained. Repair is defined as tissue restoration of a damaged tissue, without organized patterning. For example, vertebrates including humans are capable of reconstituting a functional liver following removal of up to 70 % of the original liver mass [1, 2]. Thus, liver repair includes reconstitution of the same volume but it lacks reconstruction of the same tissue pattern. Similarly, wound healing of the skin includes tissue repair by formation of a scar tissue that lacks some of the characteristic features of the original tissue. These are both examples for tissue repair that lack true regeneration or patterning. When looking at regeneration of whole body parts in salamanders, the whole limb is restored into its original form. In this case, the re-establishment of patterns is necessary because otherwise regeneration is meaningless.

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Author information

Authors and Affiliations

  1. Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH, 45469-2320, USA

    Andrea Hoffmann & Panagiotis A. Tsonis

Authors
  1. Andrea Hoffmann
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  2. Panagiotis A. Tsonis
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Corresponding author

Correspondence to Panagiotis A. Tsonis .

Editor information

Editors and Affiliations

  1. Dipartimento di Matematica, MIRIAM, Università Milano-Bicocca, Via Saldini 50, Milano, 20133, Italy

    Vincenzo Capasso

  2. Études Scientifiques, Institut des Hautes, route des Chartres 35, Bures-sur-Yvette, 91440, France

    Misha Gromov

  3. Cancer Institut Andre Lwoff, CNRS FRE 3239, Laboratoire Epigenetique et, rue Guy Moquet 7, Villejuif, 94800, France

    Annick Harel-Bellan

  4. Cancer Institut Andre Lwoff, CNRS FRE 3239, Laboratoire Epigenetique et, rue Guy Moquet 7, Villejuif, 94800, France

    Nadya Morozova

  5. Cancer Institut Andre Lwoff, CNRS FRE 3239, Laboratoire Epigenetique et, rue Guy Môquet, Villejuif, 94801, France

    Linda Louise Pritchard

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Hoffmann, A., Tsonis, P.A. (2013). Pattern Formation in Regenerating Tissues. In: Capasso, V., Gromov, M., Harel-Bellan, A., Morozova, N., Pritchard, L. (eds) Pattern Formation in Morphogenesis. Springer Proceedings in Mathematics, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20164-6_2

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