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HIV-Associated Hodgkin Lymphoma

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Diagnostic Molecular Pathology in Practice
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Abstract

A 43-year-old man presented with a two month history of intermittent fevers and diarrhea. He was diagnosed with human immunodeficiency virus (HIV) infection and over the ensuing seven years had not been regularly compliant with his highly active antiretroviral therapy (HAART). Past medical history was significant for hypertension, type 2 diabetes mellitus, and a poorly defined seizure disorder.

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References

  1. Frisch M, Biggar RJ, Engels EA et al (2001) Association of cancer with AIDS-related immunosuppression in adults. JAMA 285:1736–1745

    Article  PubMed  CAS  Google Scholar 

  2. Ryan JL, Fan H, Glaser SL et al (2004) Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segments. J Mol Diagn 6:378–385

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  3. Puren A, Gerlach JL, Weigl BH et al (2010) Laboratory operations, specimen processing, and handling for viral load testing and surveillance. J Infect Dis 201(S1):S27–S36

    Article  PubMed  CAS  Google Scholar 

  4. Broccolo F, Bossolasco S, Careddu AM et al (2002) Detection of DNA of lymphotropic herpesviruses in plasma of human immunodeficiency virus-infected patients: frequency and clinical significance. Clin Diagn Lab Immunol 9:1222–1228

    PubMed  CAS  PubMed Central  Google Scholar 

  5. Natarajan V, Bosche M, Metcalf JA et al (1999) HIV-1 replication in patients with undetectable plasma virus receiving HAART. Highly active antiretroviral therapy. Lancet 353:119–120

    Article  PubMed  CAS  Google Scholar 

  6. Fan H, Gulley ML (2001) Epstein-Barr viral load measurement as a marker of EBV-related disease. Mol Diagn 6:279–289

    Article  PubMed  CAS  Google Scholar 

  7. Savoldo B, Rooney CM, Di Stasi A et al (2007) Epstein Barr virus-specific cytotoxic T lymphocytes expression the anti-CD30? artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 110:2620–2630

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  8. Helsop HE, Slobod KS, Pule MA et al (2010) Long-term outcome of EBV-related lymphoproliferative disease in transplant recipients. Blood 115:923–935

    Google Scholar 

  9. Mbulaiteye SM, Biggar RJ, Goedert JJ et al (2003) Immune deficiency and risk for malignancy among persons with AIDS. J Acquir Immune Defic Syndr 32:527–533

    Article  PubMed  Google Scholar 

  10. Burgi A, Brodine S, Wedner S et al (2005) Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals. Cancer 104:1505–1511

    Article  PubMed  Google Scholar 

  11. Bedimo RJ, McGinnis DA, Dunlap M et al (2009) Incidence of non-ADIS-defining malignancies in the HIV-infected versus noninfected patients in the HAART era: impact of immunosuppression. J Acquir Immune Defic Syndr 52:203–208

    Article  PubMed  PubMed Central  Google Scholar 

  12. Tirelli U, Errante D, Colcetti R et al (1995) Hodgkin’s disease and human immunodeficiency virus infection: clinicopathologic and virologic features of 114 patients from the Italian Cooperative Group on AIDS and Tumors. J Clin Oncol 13:1758–1767

    PubMed  CAS  Google Scholar 

  13. Engels EA, Biggar RJ, Hall HI et al (2008) Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer 123:187–194

    Article  PubMed  CAS  Google Scholar 

  14. Grogg KL, Miller RF, Dogan A (2007) HIV infection and lymphoma. J Clin Pathol 60:1365–1372

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  15. Dolcetti R, Biocchi M, Gloghini A et al (2001) Pathologic and histogenetic features of HIV-associated Hodgkin’s disease. Eur J Cancer 37:1276–1287

    Article  PubMed  CAS  Google Scholar 

  16. Hummerl M, Anagnostopoulos I, Dallenbach F et al (1995) EBV infection patterns in Hodgkin’s disease and normal lymphoid tissue: expression and cellular localization of EBV gene products. Br J Haematol 175:263–271

    Google Scholar 

  17. Carbone A, Cesarman E, Spina M et al (2009) HIV-associated lymphomas and gamma-herperviruses. Blood 113:1213–1224

    Article  PubMed  CAS  Google Scholar 

  18. Mosialos G, Birkenbach M, Yalamanchili R et al (1995) The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:389–399

    Article  PubMed  CAS  Google Scholar 

  19. Rastelli J, Homig-Holzel C, Seagal J et al (2008) LMP1 signal can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. Blood 111:1448–1455

    Article  PubMed  CAS  Google Scholar 

  20. Gandhi MK, Lambley E, Burrows J et al (2006) Plasma Epstein-Barr virus (EBV) DNA is a biomarker for ­EBV-positive Hodgkin’s lymphoma. Clin Cancer Res 12:460–464

    Article  PubMed  CAS  Google Scholar 

Recommended Reading

  • Carbone A, Gloghini A, Serraino D et al (2009) HIV-associated Hodgkin lymphoma. Curr Opin HIV AIDS 4:3–10

    Article  PubMed  Google Scholar 

  • Fan H, Kim SC, Chima CO et al (2005) Epstein-Barr viral load as a marker of lymphoma in AIDS patients. J Med Virol 75:59–69

    Article  PubMed  Google Scholar 

  • Gulley ML (2001) Molecular diagnosis of Epstein-Barr virus-related diseases. J Mol Diagn 3:1–10

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Gulley ML, Tang W (2008) Laboratory assays for Epstein-Barr virus-related disease. J Mol Diagn 10:279–292

    Article  PubMed  PubMed Central  Google Scholar 

  • Gulley ML, Tang W (2010) Using Epstein-Barr viral load assays to diagnose, monitor, and prevent post-transplant lymphoproliferative disorder. Clin Microbiol Rev 23:350–366

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Raphael M, Said J, Borisch B et al (2008) Lymphomas associated with HIV infection. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) World Health Organization classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC Press, Lyon

    Google Scholar 

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Correspondence to Margaret L. Gulley .

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© 2011 Springer-Verlag Berlin Heidelberg

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Fedoriw, G., Gulley, M.L. (2011). HIV-Associated Hodgkin Lymphoma. In: Schrijver, I. (eds) Diagnostic Molecular Pathology in Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19677-5_14

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  • DOI: https://doi.org/10.1007/978-3-642-19677-5_14

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-19676-8

  • Online ISBN: 978-3-642-19677-5

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