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The Role of Intracellular Ca2+ in Arrhythmias in the Postmyocardial Infarction Heart

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Heart Rate and Rhythm

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Abstract

Abnormalities in intracellular Ca2+ handling occur in both Purkinje and ventricular cells that have survived in the infarcted heart. Such abnormalities are presented and contrasted in this chapter. Interestingly, these changes differ depending on the cell type (IZPC vs. IZ) and contribute differently to the arrhythmogenicity of the postmyocardial infarction (MI) substrate. Thus, it is reasonable to assume that rational drug design could derive compounds against these intracellular Ca2+ changes that would be specific not only for the cell type, but also for the type of arrhythmias occurring post-MI.

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Acknowledgments

This work was supported by grant HL58860 from the National Heart Lung and Blood Institute Bethesda, Maryland and AHFMR grant (20040163), Canada (HtK).

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Authors and Affiliations

  1. Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, NY, USA

    Wen Dun & Penelope A. Boyden

  2. University of Calgary, Calgary, AB, Canada

    Henk ter Keurs

Authors
  1. Wen Dun
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  2. Henk ter Keurs
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  3. Penelope A. Boyden
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Corresponding author

Correspondence to Penelope A. Boyden .

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Editors and Affiliations

  1. Life Sciences Academy, Usman Enclave 103, Lucknow, 226024, India

    Onkar N. Tripathi

  2. Medizinische Fakultät, Inst. für Pharmakologie u. Toxikologie, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany

    Ursula Ravens

  3. Cardiovascular Research &, Training Inst. (CVRTI), University of Utah, South 2000 East 95, Salt Lake City, 84112-5000, Utah, USA

    Michael C. Sanguinetti

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Dun, W., ter Keurs, H., Boyden, P.A. (2011). The Role of Intracellular Ca2+ in Arrhythmias in the Postmyocardial Infarction Heart. In: Tripathi, O., Ravens, U., Sanguinetti, M. (eds) Heart Rate and Rhythm. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17575-6_16

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