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Epidemiology Research and Epigenetics: Translational Epidemiology of Schizophrenia

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Brain, Behavior and Epigenetics

Part of the book series: Epigenetics and Human Health ((EHH))

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Abstract

Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical developmental stage. In this chapter, we present several epigenetic pathways associated with the risk for schizophrenia. We discuss nongenetic factors – such as paternal age, toxin exposure, and psychological stressors – which may influence human development by way of epigenetic mechanisms.

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Acknowledgments

We would like to thank Dr. Susan Harlap and Benjamin Barasch for reviewing this manuscript and providing many insightful comments.

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Authors and Affiliations

  1. New York University Langone Medical Center, Institute for Social and Psychiatric Initiatives: InSPIRES, 500 First Avenue, NBV 22N-10, New York, NY, 10016, USA

    Mary Perrin, Karine Kleinhaus, Mark Opler, Julie Messinger & Dolores Malaspina

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  1. Mary Perrin
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  2. Karine Kleinhaus
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  3. Mark Opler
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  4. Julie Messinger
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  5. Dolores Malaspina
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Correspondence to Mary Perrin .

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  1. , The Krembil Family Epigenetics Laborator, Centre for Addiction and Mental Health, College Street 250, Toronto, M5T 1R8, Ontario, Canada

    Arturas Petronis

  2. , Institute of Psychiatry, King's College London, De Crispigny Park, London, SE5 8AF, United Kingdom

    Jonathan Mill

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Perrin, M., Kleinhaus, K., Opler, M., Messinger, J., Malaspina, D. (2011). Epidemiology Research and Epigenetics: Translational Epidemiology of Schizophrenia. In: Petronis, A., Mill, J. (eds) Brain, Behavior and Epigenetics. Epigenetics and Human Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17426-1_5

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