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Transcriptional and Posttranscriptional Programming by Long Noncoding RNAs

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Long Non-Coding RNAs

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 51))

Abstract

Recently, several lines of evidence have suggested that noncoding RNAs, which include both small and long noncoding RNAs (ncRNAs), contribute to a significant portion of the transcriptome in eukaryotic organisms. However, the functional significance of this wide-spread occurrence of ncRNAs, and in particular, the long ncRNAs (lncRNAs), for organismal development and differentiation is unclear. The available evidence from a subset of lncRNAs suggests that certain lncRNAs, and/or the act of their transcription, are involved in important biological functions at the transcriptional and posttranscriptional level. This chapter discusses the epigenetic and nonepigenetic mechanisms by which lncRNAs and/or their transcription are involved in the programming of various biological functions in model systems, from yeast to mammals.

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Acknowledgments

This work was supported by the grants from the Swedish Cancer Research foundation (Cancerfonden), Swedish Medical Research Council (VR-M), and Swedish Childhood Cancer Society (Barncancerfonden) to Chandrasekhar Kanduri. Chandrasekhar Kanduri is a Senior Research Fellow supported by VR-M.

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  1. Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds Väg 20, 75185, Uppsala, Sweden

    Radha Raman Pandey & Chandrasekhar Kanduri

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  1. Radha Raman Pandey
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  2. Chandrasekhar Kanduri
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Correspondence to Chandrasekhar Kanduri .

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  1. Center for Marine Research, Ruder Boskovic Institute, Bijenicka 54, Zagreb, 10001, Croatia

    Durdica Ugarkovic

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Pandey, R.R., Kanduri, C. (2011). Transcriptional and Posttranscriptional Programming by Long Noncoding RNAs. In: Ugarkovic, D. (eds) Long Non-Coding RNAs. Progress in Molecular and Subcellular Biology(), vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16502-3_1

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