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Late Sequelae in Children with Acute Lymphoblastic Leukemia: Impact on Long-Term Survival and Quality of Life

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Childhood Leukemia

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with an annual incidence rate of three to four cases per 100,000 children (Horner et al. 2009). As shown in Fig. 9.1, there has been a tremendous progress in survival rates over the past several decades. Among patients treated with contemporary risk-based therapy, the overall 5-year survival rates exceed 85% (Brenner et al. 2001; Ries et al. 2001) and the event-free survival (EFS) rates exceed 80% (Pui and Evans 1998; Schrappe et al. 2000; Silverman et al. 2001). With this success has come the need to consider the long-term morbidity and mortality associated with treatments responsible for the improvement in survival, as well as the quality of this survival.

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Authors and Affiliations

  1. Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

    Joseph P. Neglia

  2. Children’s Oncology Group, Bethesda, MD, USA

    Maura O’Leary

  3. Department of Population Sciences, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA

    Smita Bhatia

Authors
  1. Joseph P. Neglia
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  2. Maura O’Leary
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  3. Smita Bhatia
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Correspondence to Smita Bhatia .

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Editors and Affiliations

  1. School of Medicine & Health Sciences, George Washington University, EW. Highway 4600, Bethesda, 20814, Maryland, USA

    Gregory H. Reaman

  2. Cincinnati Children's Hospital, Medical Center (CCHMC), University of Cincinnati, Burnett Avenue 3333, Cincinnati, 45229, Ohio, USA

    Franklin O. Smith

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Neglia, J.P., O’Leary, M., Bhatia, S. (2011). Late Sequelae in Children with Acute Lymphoblastic Leukemia: Impact on Long-Term Survival and Quality of Life. In: Reaman, G., Smith, F. (eds) Childhood Leukemia. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13781-5_9

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  • DOI: https://doi.org/10.1007/978-3-642-13781-5_9

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