Abstract
Spectroscopy can be done in various tissues and body parts. It has high potential in follow-up studies for disease diagnosis and treatment, drug monitoring, energy and membrane metabolism. The nuclei 1H, 31P, 13C and 19F can be used in routine examinations. The main target organs are brain, liver, muscle and implanted tumors. The results of a spectroscopic examination are very helpful in combination to an imaging session before.
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Notes
- 1.
It is not possible to separate the signals of adenosine from all other nucleobases, therefore NTP is the general term.
- 2.
Circular polarized coils are often named as quadrature coils.
- 3.
After all these steps it is possible to measure. The final processed spectrum is usuable in most of the cases and gives the missing information about the tissue composition. Washout of contrast media in animals is much faster than in humans resulting in no interference with a following spectroscopy exam.
References
Barker PB, Butterworth EJ, Boska MD, Nelson J, Welch KMA (1999) Magnesium and pH imaging of the human brain at 3.0 tesla. Magn Reson Med 41:400–406
Bollard ME, Garrod S, Holmes E, Lindon JC, Humpfer E, Spraul M, Nicholson JK (2000) High-resolution 1H and 1H-13C magic angle spinning NMR spectroscopy of rat liver. Magn Reson Med 44:201–207
Bottomley PA, Hardy CJ (1989) Rapid, reliable in vivo assays of human phosphate metabolites by nuclear magnetic resonance. Clin Chem 35:392–395
de Graaf R (1998) In vivo NMR spectroscopy. Wiley, New York
Dong Z, Dreher W, Leibfritz D (2006) Toward quantitative short-echo-time in vivo proton MR spectroscopy without water suppression. Magn Reson. Med 55:1441–1446
Neumann-Haefelin C, Kuhlmann J, Belz U, Kalisch J, Quint M, Gerl M, Juretschke P, Herling AW (2003) Determinants of intramyocellular lipid concentrations in rat hind leg muscle. Magn Reson Med 50:242–248
Ordidge RJ, Connelly A, Lohmann JAB (1986) Image-selected in Vivo spectroscopy (ISIS). A new technique for spatially selective nmr spectroscopy. J Magn Reson 66:283–294
Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983–988
Petroff OAC, Prichard JW, Behar KL, Alger JR, den Hollander JA, Shulman RG (1985) Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology 35:781–788
Podo F (1999) Tumour phospholipid metabolism. NMR Biomed 12(7):413–439
Renema WKJ, Schmidt A, van Asten JJA, Oerlemans F, Ullrich K, Wieringa B, Isbrandt D, Heerschap A (2003) NMR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: validation of an animal model to study creatine deficiency. Magn Reson Med 50:936–943
Street JC, Szwergold BS, Matei C, Kappler F, Koutcher JA (1997) Study of the metabolism of choline and phosphatidylcholine in tumors in vivo using phosphonium-choline. MRM 3:769–775
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Becker, M. (2011). MR Spectroscopy. In: Kiessling, F., Pichler, B. (eds) Small Animal Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12945-2_14
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DOI: https://doi.org/10.1007/978-3-642-12945-2_14
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