Abstract
In this chapter, we will describe first an overview of current concepts of epidermal barrier function emphasizing very recent work on the influence of pigmentation on barrier function. Then, we will assess how these mechanisms go awry in the disease, atopic dermatitis, as the prototype for a barrier-driven, inflammatory dermatosis.
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Notes
- 1.
Dr. Elias is a co-inventor of this University of California patented technology. He is a consultant to Promius Pharmaceuticals and to PediaPharm Inc., which markets this technology in the United States and in Canada, respectively.
Abbreviations
- AD:
-
Atopic Dermatitis
- AMP:
-
Antimicrobial Peptides
- Cer:
-
Ceramides
- FLG:
-
Filaggrin
- FFA:
-
Free Fatty Acids
- GC:
-
Glucocorticoids
- hBD:
-
Human Β-Defensins
- hCAP:
-
Human Cathelicidin
- IL:
-
Interleukin
- IV:
-
Ichthyosis Vulgaris
- LB:
-
Lamellar Bodies
- LEKTI:
-
Lymphoepithelial Kazal-Type Trypsin Inhibitor
- NS:
-
Netherton Syndrome
- PAR2:
-
Plasminogen Activator Type 2 Receptor
- SP:
-
Serine Protease
- SC:
-
Stratum Corneum
- t-UCA:
-
Trans-urocanic Acid
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Acknowledgements
This work was supported by NIH grant AR19098 and DOD grant W81XWH-05-2-0094, and by the Medical Research Service, Department of Veterans Affairs.
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Elias, P.M., Wakefield, J.S. (2010). Skin Barrier Function. In: Krutmann, J., Humbert, P. (eds) Nutrition for Healthy Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12264-4_4
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