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Noncoding RNAs as Therapeutic Targets

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RNA Technologies and Their Applications

Part of the book series: RNA Technologies ((RNATECHN))

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Abstract

Noncoding RNAs are key players in the regulation of complex cellular processes. Over the years, it has been demonstrated that their abnormal expression is associated with many human pathologies including developmental and neurobehavioral disorders, diabetes, obesity, and cancer. A wide spectrum of activities and a large number of genes that are regulated by RNA-dependent mechanisms makes the ncRNA molecules attractive targets for developing next generation therapeutic agents. This chapter outlines the principles of RNA regulation, the involvement of various RNAs in human diseases, and the strategies of application of ncRNA-targeted therapeutic approaches.

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Acknowledgments

This work was supported by grants from the Polish Ministry of Science and Higher Education.

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  1. Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Noskowskiego 12, 61-704, Poznan, Poland

    Maciej Szymański & Jan Barciszewski

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  1. Maciej Szymański
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Correspondence to Maciej Szymański .

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  1. Inst. Chemie und Biochemie, FU Berlin, Thielallee 63, Berlin, 14195, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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Szymański, M., Barciszewski, J. (2010). Noncoding RNAs as Therapeutic Targets. In: Erdmann, V., Barciszewski, J. (eds) RNA Technologies and Their Applications. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12168-5_18

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