Abstract
As a part of the airway mucosa, nasal polyps express a wide range of mucin genes and proteins. Nasal polyps express the first nine mucin genes studied so far (MUCs1–4, 5AC, 5B and 6–8). More mucin genes are expected to be expressed in nasal polyps. The wide range of mucin expression patterns reflects a wide range of internal and external environmental factors involved in the development of nasal polyps. Mucin genes up-regulated in nasal polyps include MUC1, 2, 4, 5AC, 5B and 8. Sub-mucosal glands play a more important role in mucin expression than surface epithelium. Most of the studies on mucin expression in nasal polyps are focused on basic science. The role of steroids in modulating mucin gene expression in nasal polyps is still unclear. Further studies are needed to illustrate the role of different variables that control mucin expression in nasal polyps. The role of inflammatory mediators needs to be studied to help invent new treatment modalities.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ali MS, Pearson JP (2007) Upper airway mucin gene expression: a review. Laryngoscope 117(5):932–938
Ali MS, Wilson JA, Pearson JP (2002) Nasal mucus as a model for sinus mucin gene studies in chronic sinusitis. Laryngoscope 112:326–331
Ali MS, Wilson JA, Bennett M et al (2005) Mucin gene expression in nasal polyps. Acta Otolaryngol 125(6):618–624
Ali MS, Hutton DA, Wilson JA et al (2005) Major secretory mucin expression in chronic sinusitis. Otolaryngol Head Neck Surg 133(3):423–428
Audie JP, Janin A, Porchet N et al (1993) Expression of human mucin genes in respiratory, digestive and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem 41:1479–1485
Aust MR, Madsen CS, Jennings A et al (1997) Mucin mRNA expression in normal and vasomotor inferior turbinates. Am J Rhinol 11:292–302
Bai CH, Song SY, Kim YD (2007) Effect of glucocorticoid on the MUC4 gene in nasal polyps. Laryngoscope 117(12):2169–2173
Bai CH, Song SY, Kim YD (2007) The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. Auris Nasus Larynx 34(2):203–206
Biesbrock AR, Bobek LA, Levin MJ (1995) Expression and biological activity of human salivary apomucin (MUC7). Glycoconj J 12:559–560
Burgel PR, Escudier E, Coste A et al (2000) Relation of epidermal growth factor receptor expression to goblet cell hyperplasia in nasal polyps. J Allergy Clin Immunol 106(4):705–712
Burgel PR, Cardell LO, Ueki IF et al (2004) Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps. Eur Respir J 24(4):594–600
Cho KN, Choi JY, Kim CH et al (2005) Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. J Biol Chem 280(8):6676–6681
Ciccarelli FD, Doerks T, Bork P (2002) AMOP, a protein module alternatively spliced in cancer cells. Trends Biochem Sci 27(3):113–115
Dabbagh K, Takeyama K, Lee HM et al (1999) IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 162(10):6233–6237
Damera G, Xia B, Ancha HR et al (2006) IL-9 modulated MUC4 gene and glycoprotein expression in airway epithelial cells. Biosci Rep 26(1):55–67
Ding GQ, Zheng CQ (2007) The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis. Am J Rhinol 21(3):359–366
Escande F, Lemaitre L, Moniaux N et al (2002) Genomic organization of MUC4 mucin gene. Towards the characterization of splice variants. Eur J Biochem 269(15):3637–3644
Fischer B, Voynow J (2000) Neutrophil elastase induces MUC5AC messenger RNA expression by an oxidant-dependent mechanism. Chest Suppl 117:317S–320S
Ishinaga H, Takeuchi K, Kishioka C et al (2002) Effects of dexamethasone on mucin gene expression in cultured human nasal epithelial cells. Laryngoscope 112(8):1436–1440
Kim CH, Song KS, Kim SS et al (2000) Expression of MUC5AC mRNA in the goblet cells of human nasal mucosa. Laryngoscope 110(12):2110–2113
Kim CH, Kim HJ, Song KS et al (2005) MUC8 as a ciliated cell marker in human nasal epithelium. Acta Otolaryngol 125(1):76–81
Kim SS, Kim KS, Lee JG et al (2000) Levels of intracellular protein and messenger RNA of mucin and lysozyme in normal human nasal and polyp epithelium. Laryngoscope 110(2):276–280
Kim YD, Kwon EJ, Park DW et al (2002) Interleukin-1β induces MUC2 and MUC5AC synthesis through cyclooxygeanase-2 in NCI-H292 cell. Mol Pharmacol 62:1112–1118
Levine SJ, Larivee P, Logun C et al (1995) Tumor necrosis factor-alpha induces mucin hypersecretion and MUC2 gene expression by human airway epithelial cells. Am J Respir Cell Mol Biol 12:196–204
Louahed J, Toda M, Jen J et al (2000) Interleukin-9 upregulates mucus expression in the airways. Am J Respir Cell Mol Biol 22:649–656
Lü H, Guo Y, Dong Z (2004) Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium. Lin Chuang Er Bi Yan Hou Ke Za Zhi 18(11):649–650 (Abstract)
Martínez-Antón A, Debolós C, Garrido M et al (2006) Mucin genes have different expression patterns in healthy and diseased upper airway mucosa. Clin Exp Allergy 36(4):448–457
Mazzuca M, Lhermitte M, Lafitte JJ et al (1982) Use of lectins for detection of glycoconjugates in the glandular cells of the human bronchial mucosa. J Histochem Cytochem 30(9):956–966
Mogensen C, Tos M (1977) Density of goblet cells in the normal adult nasal turbinates. Anat Anz 142:322–330
Moniaux N, Nollet S, Porchet N et al (1999) Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem J 338(2):325–333
Norlander T, Fukami M, Westrin KM et al (1993) Formation of mucosal polyps in the nasal and maxillary sinus cavities by infection. Otolaryngol Head Neck Surg 109:522–529
Peñia MT, Aujla PK, Zudaire E et al (2007) Localization and expression of MUC5B and MUC7 mucins in pediatric sinus mucosa. Ann Otol Rhinol Laryngol 116(5):389–397
Reader JR, Hyde DM, Schelegle ES et al (2003) Interleukin-9 induces mucous cell metaplasia independent of inflammation. Am J Respir Cell Mol Biol 28(6):664–672
Reid CJ, Gould S, Harris A (1997) Developmental expression of mucin genes in the human respiratory tract. Am J Respir Cell Mol Biol 17:592–598
Roca-Ferrer J, Mullol J, Perez M et al (2000) effect of topical glucocorticoids on in vitru lactoferrin glandular secretion: comparison between human upper and lower airways. J Allergy Clin Immunol 106:1053–1062
Sama A, Severn T, Hutton DA et al (2000) Mucin gene expression in human hypertrophic nasal mucosa: allergic vs non-allergic. Presented in the X1X International Symposium on Infection and Allergy of the Nose, Barcelona
Seong JK, Koo JS, Lee WJ et al (2002) Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal polyps and cultured nasal epithelium. Acta Otolaryngol 122(4):401–407
Sharma P, Dudus L, Nielsen PA et al (1998) MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mol Biol 19(1):30–37
Shinogi J, Harada T, Nonoyama T et al (2001) Quantitative analysis of mucin and lectin in maxillary sinus fluids in patients with acute and chronic sinusitis. Laryngoscope 111(2):240–245
Smirnova MG, Kiselev SL, Birchall JP et al (2001) Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-6. Eur Cytokine Netw 12(1):119–125
Song KS, Seong JK, Chung KC et al (2003) Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells. J Biol Chem 278(37):34890–34896
Suzuki S, Takeuchi K, Ishinaga H et al (2008) Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. Pharmacology 81(3):221–228
Takeuchi K, Yuta A, Sakahura Y (1995) Mucin gene expression in the nose and maxillary sinus. Am J Otolaryngol 16:391–395
Thornton DJ, Carlstedt I, Howard M et al (1996) Respiratory mucins: identification of core proteins and glycoforms. Biochem J 316:967–975
Wang J, Yang B (2004) Effects of dexamethasone on mucin gene expression in human nasal polyps. Lin Chuang Er Bi Yan Hou Ke Za Zhi 18(2):74–76 (Abstract)
Wickstrom C, Davies JR, Eriksen GV et al (1998) MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J 334:685–693
Yoon JH, Kim KS, Kim HU et al (1999) Effects of TNF-α and IL-1β on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelium. Acta Otolaryngol 119:905–910
Young Kim J, Kim CH, Kim KS et al (2004) Extracellular signal-regulated kinase is involved in tumor necrosis factor-alpha-induced MUC5AC gene expression in cultured human nasal polyp epithelial cells. Acta Otolaryngol 124(8):953–957
Zuhdi AM, Piazza FM, Selby DM et al (2000) Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 22(3):253–260
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Ali, M.ES. (2010). Mucin Expression in Nasal Polyps. In: Önerci, T., Ferguson, B. (eds) Nasal Polyposis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11412-0_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-11412-0_8
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11411-3
Online ISBN: 978-3-642-11412-0
eBook Packages: MedicineMedicine (R0)