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Eosinophil

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Nasal Polyposis

Abstract

Chronic rhinosinusitis (CRS) is characterized by distinct patterns of inflammation, mucous gland hyperplasia, and remodeling that result in various clinical subtypes. CRS with nasal polyps (NP) is characterized by increased populations of eosinophils, Th2-like lymphocytes, fibroblasts, goblet cells, and mast cells. The pathology of CRS with NP is similar to asthma and is frequently diagnosed in association with asthma. This chapter examines the potential role the eosinophil plays in the pathophysiology of these diseases with focus on eosinophil development, production of inflammatory mediators, and upregulation of adhesion molecules that are important in cell trafficking.

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Authors and Affiliations

  1. Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA, 22908-1355, USA

    Adrienne Tiñana, Larry Borish & John W. Steinke

Authors
  1. Adrienne Tiñana
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  2. Larry Borish
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  3. John W. Steinke
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Corresponding author

Correspondence to Larry Borish .

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Editors and Affiliations

  1. Faculty of Medicine, Dept. of Otorhinolaryngology, Hacettepe University, Ankara, 06100, Turkey

    T. Metin Önerci

  2. School of Medicine, Dept. Otolaryngology, University of Pittsburgh, Locust Street 1400, Pittsburgh, 15219, USA

    Berrylin J. Ferguson

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© 2010 Springer-Verlag Berlin Heidelberg

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Tiñana, A., Borish, L., Steinke, J.W. (2010). Eosinophil. In: Önerci, T., Ferguson, B. (eds) Nasal Polyposis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11412-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-11412-0_5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11411-3

  • Online ISBN: 978-3-642-11412-0

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