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Olfaction and Nasal Polyposis

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Nasal Polyposis

Abstract

Smell plays an important role in the quality of life. Olfactory dysfunction is most commonly caused by nasal polyposis (NP). Smell is a sense that is all too often forgotten and may escape the notice of both surgeons and patients. Optimizing the medical treatment of mucosal disease is important in providing symptomatic relief either on its own or in conjunction with surgery. Routine preoperative smell testing is advisable in assessing patients prior to surgery. Routine preoperative smell testing is advisable in assessing patients prior to surgery. Subjective test methods are frequently used to assess olfaction because they can be done quickly and easily in a compliant patient – e.g., screening tests of olfaction. The exact size of the olfactory neuroepithelium in humans is still not well established. Olfactory function correlates with disease severity. Far less or no surgery is needed if medical treatment has been successful. In severe olfactory loss with CRS and NP, the objective measures of olfaction generally improve significantly after endoscopic sinus surgery, particularly if the olfactory cleft is widened. Impairment of smell may be the first sign of a recurrence of nasal disease and helps to motivate the patient to accept long-term medical treatment.

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References

  1. Alobid I, Benitez P, Bernal-Sprekelsen M, Roca J, Alonso J, Picado C et al (2005) Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments. Allergy 60(4):452–458

    Article  PubMed  CAS  Google Scholar 

  2. Apter AJ, Mott AE, Frank ME, Clive JM (1995) Allergic rhinitis and olfactory loss. Ann Allergy Asthma Immunol 75:311–316

    PubMed  CAS  Google Scholar 

  3. Auffermann H, Mathe F, Gerull G, Mrowinski D (1993) Olfactory evoked potentials and contingent negative variation simultaneously recorded for diagnosis of smell disorders. Ann Otol Rhinol Laryngol 102:6–10

    PubMed  CAS  Google Scholar 

  4. Blomqvist EH, Lundbald L, Anggard A, Haraldsson PO, Stjarne P (2001) A randomized controlled study evaluating medical treatment versus surgical treatment in addition to medical treatment of nasal polyposis. J Allergy Clin Immunol 107(2):224–228

    Article  PubMed  CAS  Google Scholar 

  5. Briner HR, Simmen D (1999) Smell diskettes as screening test of olfaction. Rhinology 37:145–148

    PubMed  CAS  Google Scholar 

  6. Briner HR, Simmen D, Jones N (2003) Impaired sense of smell in patients with nasal surgery. Clin Otolaryngol 28:417–419

    Article  PubMed  CAS  Google Scholar 

  7. Cain WS, Goodspeed RB, Gent JF, Leonard G (1988) Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 98:83–88

    Article  PubMed  CAS  Google Scholar 

  8. Dalton P (2004) Olfaction and anosmia in rhinosinusitis. Curr Allery Asthma Rep 4:230–236

    Article  Google Scholar 

  9. Doty R, Mishra A (2001) Olfaction and its alteration by nasal obstruction, rhinitis and rhinosinusitis. Laryngoscope 111:409–423

    Article  PubMed  CAS  Google Scholar 

  10. Doty RL, Shaman P, Kimmelman CP, Dann MS (1984) University of Pennsylvania smell identification test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 94:176–178

    Article  PubMed  CAS  Google Scholar 

  11. Doty RL, Marcus A, Lee WW (1996) Development of the 12-item cross-cultural smell identification test (CC-SIT). Laryngoscope 106:353–356

    Article  PubMed  CAS  Google Scholar 

  12. Estrem SA, Renner G (1987) Disorders of smell and taste. Otolaryngol Clin North Am 20:133–147

    PubMed  CAS  Google Scholar 

  13. Ferguson BJ, Seiden AM (2005) Chronic rhinosinusitis. Otolaryngol Clin North Am 36(6):1–1393

    Google Scholar 

  14. Feron F, Perry C, Mc Grath JJ, Mackay-Sim A (1998) New techniques for biopsy and culture of human olfactory epithelial neurons. Arch Otolaryngol Head Neck Surg 124(8): 861–866

    PubMed  CAS  Google Scholar 

  15. Fokkens W, Lund V et al (2007) European position paper on rhinosinusitis and nasal polyposis. Rhinol Suppl 20:1–88

    PubMed  Google Scholar 

  16. Gottfried JA, Deichmann R, Winston JS, Dolan RJ (2002) Functional heterogeneity in human olfactory cortex: an event-related functional magnetic resonance imaging study. Neuroscience 22:10819–10828

    PubMed  CAS  Google Scholar 

  17. Hashimoto Y, Fukazawa K et al (2004) Usefulness of the odour stick identification test for Japanese patients with olfactory dysfunction. Chem Senses 29(7):565–571

    Article  PubMed  Google Scholar 

  18. Hoffman HJ, Davis B, Cruickshanks KJ. Symposium overview: Epidemiological studies of taste and smell. Ann N Y Acad Sci. (2009) 1170:511–3.

    Article  PubMed  Google Scholar 

  19. Hornung DE (2006) Nasal anatomy and the sense of smell. In: Hummel T, Welge Lüssen A (eds) Taste and smell. An update. Adv Otorhinolaryngol 63:1–22

    Google Scholar 

  20. Hornung DE, Enns MP (1994) Taste and smell components of flavor. In: Birch GG, Campbell-Platt G (eds) Synergy. Intercept, Andover, pp 145–154

    Google Scholar 

  21. Hummel T, Kobal G (2001) Olfactory event-related potentials. In: Simon SA, Nicolelis MAL (eds) Methods and frontiers in chemosensory research. CRS, Boca Raton, pp 429–464

    Google Scholar 

  22. Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) “Sniffin’ Sticks”: olfactory performance assessed by the combined testing of odour identification, odour discrimination and olfactory threshold. Chem Senses 22:39–52

    Article  PubMed  CAS  Google Scholar 

  23. Jackman A, Doty R (2005) Utility of a three-item smell identification test in detecting olfactory dysfunction. Laryngoscope 115(12):2209–2212

    Article  PubMed  Google Scholar 

  24. Jones NS, Rog D (1998) Olfaction: a review. JLO 11:11–24

    Google Scholar 

  25. Kern CR (2000) Chronic sinusitis and anosmia. Pathologic changes in the olfactory mucosa. Laryngoscope 110:1071–1077

    Article  PubMed  CAS  Google Scholar 

  26. Kobal G, Hummel T, Sekinger B, Barz S, Roscher S, Wolf S (1996) “Sniffin’ Sticks”: screening of olfactory performance. Rhinology 34:222–226

    PubMed  CAS  Google Scholar 

  27. Landis BN, Frasnelli J, Reden J, Lacroix JS, Hummel T (2005) Differences between orthonasal and retronasal olfactory functions in patients with loss of the sense of smell. Arch Otolaryngol Head Neck Surg 131:977–981

    Article  PubMed  Google Scholar 

  28. Leopold DA, Hummel T, Schwob JE, Hong SC, Knecht M, Kobal G (2000) Anterior distribution of human olfactory epithelium. Laryngoscope 110:417–421

    Article  PubMed  CAS  Google Scholar 

  29. Nordin S, Nyroos M (2002) Applicability of the Scandinavian Odour Identification Test: a Finnish-Swedish comparison. Acta Otolaryngol 122(3):294–297

    Article  PubMed  CAS  Google Scholar 

  30. O’Doherty J, Rolls ET, Francis S, Bowtell R, McGlone F (2001) Representation of pleasant and aversive taste in the human brain. J Neurophysiol 85:1315–1321

    PubMed  Google Scholar 

  31. Pade J, Hummel T (2008) Olfactory function following nasal surgery. Laryngoscope 118:1260–1264

    Article  PubMed  Google Scholar 

  32. Pierce JD, Doty RL, Amore JE (1996) Analysis of position of trial sequence and type of diluent on the detection threshold for phenyl ethyl alcohol using a single staircase method. Percept Mot Skills 82:451–458

    Article  PubMed  Google Scholar 

  33. Ragab SM, Lund VJ, Scadding G (2004) Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial. Laryngoscope 114(5):923–930

    Article  PubMed  Google Scholar 

  34. Seiden AM, Duncan J (2001) The diagnosis of a conductive olfactory loss. Laryngoscope 111:9–14

    Article  PubMed  CAS  Google Scholar 

  35. Shepert GM (2004) The human sense of smell: are we better than we think. Biology 2:572–575

    Google Scholar 

  36. Simmen D, Briner HR (2006) Olfaction in rhinology – methods of assessing the sense of smell. Rhinology 44:98–101

    PubMed  Google Scholar 

  37. Simmen DB, Scherrer JL, Moe K, Heinz B (1999) A dynamic direct visualization model for the Study of Nasal Airflow. Arch Otolaryngol Head Neck Surg 125:1015–1021

    PubMed  CAS  Google Scholar 

  38. Small DM, Gerber JC, Mak YE et al (2005) Differential neural responses evoked by orthonasal versus retronasal odorant perception in humans. Neuron 47:593–605

    Article  PubMed  CAS  Google Scholar 

  39. Thomas-Danguin T, Rouby C et al (2003) Development of the ETOC: a European test of olfactory capabilities. Rhinology 41(3):142–151

    PubMed  Google Scholar 

  40. Treyer V, Koch H, Briner HR, Jones NS, Buck A, Simmen D (2006) Male subjects who could not perceive the pheromone 5a-androst-16-en-3-one, produced similar orbito-frontal changes on PET compared with perceptible phenylethyl alcohol (rose). Rhinology 4:279–282

    Google Scholar 

  41. Van Toller S (1999) Assessing the impact of anosmia: review of a questionnaire’s finding. Chem Senses 24:705–712

    Article  PubMed  CAS  Google Scholar 

  42. Vento SI, Simola M, Ertama LO, Malmberg CH (2001) Sense of smell in long standing nasal polyposis. Am J Rhinol 15:159–163

    Article  PubMed  CAS  Google Scholar 

  43. Zhao K, Scherer PW, Hajiloo SA, Dalton P (2004) Effect of anatomy on human nasal airflow and odorant transport patterns: implications for olfaction. Chem Senses 29(5):365–379

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. ORL-Zentrum, The Hirslanden Clinic, Witellikerstrasse 40, 8032, Zürich, Switzerland

    Daniel B. Simmen

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Queens Medical Centre, University Hospital, Nottingham, UK

    Nick S. Jones

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  1. Daniel B. Simmen
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  2. Nick S. Jones
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Correspondence to Nick S. Jones .

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Editors and Affiliations

  1. Faculty of Medicine, Dept. of Otorhinolaryngology, Hacettepe University, Ankara, 06100, Turkey

    T. Metin Önerci

  2. School of Medicine, Dept. Otolaryngology, University of Pittsburgh, Locust Street 1400, Pittsburgh, 15219, USA

    Berrylin J. Ferguson

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Simmen, D.B., Jones, N.S. (2010). Olfaction and Nasal Polyposis. In: Önerci, T., Ferguson, B. (eds) Nasal Polyposis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11412-0_19

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  • DOI: https://doi.org/10.1007/978-3-642-11412-0_19

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  • Print ISBN: 978-3-642-11411-3

  • Online ISBN: 978-3-642-11412-0

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