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IGF-I treatment of adult Laron syndrome patients for a period of 9 months had beneficial metabolic effects on protein and fat metabolism. An improvement in kidney function was also registered.
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Abs R, Mattsson AF, Bengtsson BA, Feldt-Rasmussen U, Góth MI, Koltowska-Häggström M, Monson JP, Verhelst J, Wilton P; KIMS Study Group (2005) Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database. Growth Horm IGF Res 15:349–359
Assmann G, Schulte H, von Eckardstein A (1996) Hyper triglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men. Am J Cardiol 77:1179–1184
Bianda T, Schmid C (1998) Effects of short-term treatment with insulin-like growth factor-I and growth hormone on serum lipoprotein (a) in growth hormone-deficient adults. Eur J Endocrinol 138:189–190
Jorgensen JOL, Christiansen JS (eds) (2005) Growth hormone deficiency in adults. S. Karger AG, Basel
Juul A, Jorgensen JOL (eds) (2000) Growth hormone in adults. Physiological and clinical aspects, 2nd edn. Cambridge, Cambridge University Press
Kanety H, Hemi R, Ginsberg S, Pariente C, Yissachar E, Barchoder E, Funahashi T, Laron Z (2009) Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity. Eur J Endocrinol 161(6):837–844
Klinger B, Anin S, Flexer Z, Laron Z (1993) IGF-1 treatment of adult patients with Laron syndrome. In: Laron Z, Parks JS (eds) Lessons from Laron syndrome (LS) 1966–1992. Pediatric and adolescent endocrinology, vol. 24. Karger, Basel, pp 27–33
Klinger B, Jensen LT, Silbergeld A, Laron Z (1996) Insulin-like growth factor-I raises serum procollagen levels in children and adults with Laron syndrome. Clin Endocrinol 46:423–429
Koltowska-Häggström M, Mattsson AF, Monson JP, Kind P, Badia X, Casanueva FF, Busschbach J, Koppeschaar HP, Johannsson G (2006) Does long-term GH replacement therapy in hypopituitary adults with GH deficiency normalise quality of life? Eur J Endocrinol 155:109–119
Laron Z (1996) Metabolic consequences of early growth hormone and insulin-like growth factor-I deficiency. In: Boulton J, Laron Z, Rey J (eds) Long term consequences of early feeding. Nestle Nuitrition Workshop Series, vol 36. Lippincott-Raven, Philadelphia, pp 225–236
Laron Z (2001) Consequences of not treating children with Laron syndrome (primary growth hormone insensitivity). J Pediatr Endocrinol Metab 14(suppl 5):1243–1248
Laron Z (2004) Laron syndrome (primary growth hormone resistance or insensitivity). The personal experience 1958-2003. J Clin Endocrinol Metab 89:1031–1044
Laron Z, Butenandt O (eds) (1993) Growth hormone replacement therapy in adults -pros and cons. Freund, Tel Aviv, p 188
Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaissman N (2006) Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clin Endocrinol 65:114–117
Laron Z, Ginsberg S, Pariente C, Kanety H (2007) Serum adiponectin levels in patients with Laron syndrome are unexpectedly high (Abstract #P2–67), In: 89th Annual Meeting of The Endocrine Society, Toronto, Canada, Program & Abstracts Book, p 343
Laron Z, Klinger B (1994) IGF-I treatment of adult patients with Laron syndrome: preliminary results. Clin Endocrinol 41: 631–638
Laron Z, Klinger B, Erster B, Anin S (1988) Effects of acute administration of insulin like growth factor I in patients with Laron-type dwarfism. Lancet ii:1170–1172
Laron Z, Klinger B, Silbergeld A, Wang XL (1997a) Opposing effects of growth hormone and insulin-like growth factor -I on serum lipoprotein (a). ISPAD Workshop on Role of GH and IGF-I in Carbohydrate and Lipid Metabolism. J Pediatr Endocrinol Metab 10(suppl 1):143–149
Laron Z, Pertzelan A, Karp M (1968) Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci 4:883–894
Laron Z, Klinger B, Silbergeld A (1999) Serum insulin-like growth factor-I (IGF-I) levels during long-term IGF-I treatment of children and adults with primary GH resistance (Laron syndrome). J Pediatr Endocrinol Metab 12:145–152
Laron Z, Wang XL, Klinger B, Silbergeld A, Wilcken DEL (1996) Insulin-like growth factor-I decreases serum lipoprotein(a) during long-term treatment of patients with Laron syndrome. Metabolism 45:1263–1266
Laron Z, Wang XL, Klinger B, Silbergeld A, Wilcken DEL (1997b) Growth hormone increases and insulin-like growth factor-I decreases circulating lipoprotein(a). Eur J Endocrinol 136:377–381
Mauras N, Martinez V, Rini A, Guevara-Aguirre J (2000) Recombinant human insulin-like growth factor I has significant anabolic effects in adults with growth hormone receptor deficiency: studies on protein, glucose, and lipid metabolism. J Clin Endocrinol Metab 85:3036–3042
Olivecrona H, Johansson AG, Lindh E, Ljunghall S, Berglund L, Angelin B (1995) Hormonal regulation of serum lipoprotein(a) levels. Contrasting effects of growth hormone and insulin-like growth factor-I. Arterioscler Thromb Vasc Biol 15: 847–849
Oscarsson J, Ottosson M, Wiklund O, Mårin P, Vikman-Adolfsson K, Björntorp P, Edén S (1994) Low dose continuously infused growth hormone results in increased lipoprotein(a) and decreased low density lipoprotein cholesterol concentrations in middle-aged men. Clin Endocrinol (Oxf) 41:109–116
Vaccarello MA, Diamond FB Jr, Guevara-Aguirre J, Rosenbloom AL, Fielder PJ, Gargosky S, Cohen P, Wilson K, Rosenfeld RG (1993) Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome. J Clin Endocrinol Metab 77:273–280
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Laron, Z. (2011). IGF-I Treatment of Adult Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_46
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DOI: https://doi.org/10.1007/978-3-642-11183-9_46
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