Core Message
Some obese patients with Laron syndrome develop NAFLD (non-alcoholic fatty liver disease). No clear metabolic correlation could be established.
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References
Begriche K, Igoudjil A, Pessayre D, Fromenty B (2006) Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 6:1–28
Bugianesi E, Pagotto U, Manini R, Vanni E, Gastaldelli A, de Iasio R, Gentilcore E, Natale S, Cassader M, Rizzetto M, Pasquali R, Marchesini G (2005) Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. J Clin Endocrinol Metab 90:3498–3504
Dixon JB, Bhathal PS, O’Brien PE (2001) Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 121:91–100
Kanety H, Hemi R, Ginsberg S, Pariente C, Yissachar E, Barchoder E, Funahashi T, Laron Z (2009) Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity. Eur J Endocrinol 161(6):837–44
Knobler H, Schattner A, Zhornicki T, Malnick SD, Keter D, Sokolovskaya N, Lurie Y, Bass DD (1999) Fatty liver—an additional and treatable feature of the insulin resistance syndrome. QJM 92:73–79
Laron Z (2004) Laron syndrome (primary growth hormone resistance or insensitivity). The personal experience 1958-2003. J Clin Endocrinol Metab 89:1031–1044
Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaissman N (2006a) Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clin Endocrinol 65:114–117
Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N (2006b) Long-term IGF-I treatment of children with Laron syndrome increases adiposity. Growth Horm IGF Res 16:61–64
Laron Z, Ginsberg S, Pariente C, Kanety H (2007) Serum adiponectin levels are high in untreated and IGF-I treated patients with Laron syndrome (Abstract #P03-418). Horm Res 68(Suppl 1):128
Laron Z, Ginsberg S, Webb M (2008) Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary report. Growth Horm IGF Res 18:434–438
Laron Z, Kelijman M, Pertzelan A, Keret R, Shoffner JM, Parks JS (1985) Human growth hormone gene deletion without antibody formation or growth arrest during treatment–a new disease entity? Isr J Med Sci 21:999–1006
Laron Z, Klinger B (1993) Body fat in Laron syndrome patients: effect of insulin-like growth factor I treatment. Horm Res 40:16–22
Matthews DR, Hosker JP, Rudenski SA, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419
Perlemuter G, Bigorgne A, Cassard-Doulcier A-M, Naveau S (2007) Nonalcoholic fatty liver disease: from pathogenesis to patient care. Nature Clin Pract Endocrinol Metab 3:458–469
Stefan N, Kantartzis K, Haring HU (2008) Causes and metabolic consequences of fatty liver. Endocr Rev 29:939–960
Trujillo ME, Scherer PE (2006) Adipose tissue-derived factors: Impact on health and disease. Endocr Rev 27:762–778
Webb M, Yeshua H, Zelber-Sagi S, Santo M, Barazovski E, Katz R, Halpern Z, Oren R (2006) A practical index for ultrasonographic quantification of liver steatosis, (Abstract 1230). Hepatology 44 (Suppl):648A
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Laron, Z. (2011). Nonalcoholic Fatty Liver Disease (Nafld) in Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_14
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DOI: https://doi.org/10.1007/978-3-642-11183-9_14
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