Core Message
The sequence of sexual development in boys and girls is described and illustrated. Despite delayed puberty mainly in boys, both genders reach full sexual development and reproductive potential.
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References
Adashi EY, Resnick CE, Hernandez ER, Svoboda ME, Van Wyk JJ (1988) Characterization and regulation of a specific cell membrane receptor for somatomedin-C/insulin-like growth factor I in cultured rat granulosa cells. Endocrinology 122:194–201
Ben-Amitai D, Laron Z (2009) Insulin-like growth factor-1 (IGF-1) deficiency prevents the appearance of micromedones and acne (Abstract PO2-186). 8th Joint Meeting of LWPES/ESPE, New York. Horm Res 73(suppl 3):265–266
Capraro VJ (1977) Breast problems in adolescence. In: Adolescent gynecology – 7th Ross Roundtable. Ross Laboratories, Columbus, OH, pp 25–31
Dor J, Ben-Shlomo I, Lunenfeld B, Pariente C, Levran D, Karasik A, Seppälä M, Mashiach S (1992) Insulin-like growth factor-I (IGF-I) may not be essential for ovarian follicular development: evidence from IGF-I deficiency. J Clin Endocrinol Metab 74:539–542
Flatau E, Josefsberg Z, Reisner SH, Bialik O, Laron Z (1975) Penile size in the newborn infant. J Pediatr 87:663–664
Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of hand and wrist. Stanford University Press, Stanford, CA
Klinger B, Anin S, Silbergeld A, Eshet R, Laron Z (1998) Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome. Clin Endocrinol 48:81–87
Laron Z (1984) Laron type dwarfism (hereditary somatomedin deficiency): a review. In: Frick P, Von Harnack GA, Kochsiek K, Martini GA, Prader A (eds) Advances in internal medicine and pediatrics. Springer, Berlin, pp 117–150
Laron Z (2001) Consequences of not treating children with Laron syndrome (primary growth hormone insensitivity). J Pediatr Endocrinol Metab 14(suppl 5):1243–1248
Laron Z (2004) Laron syndrome (primary growth hormone resistance or insensitivity). The personal experience 1958-2003. J Clin Endocrinol Metab 89:1031–1044
Laron Z (2006) (2006) Development and biological function of the female gonads and genitalia in IGF-I deficiency – Laron syndrome as a model. Pediatr Endocrinol Rev 3:188–191
Laron Z, Klinger B (1998) Effect of insulin-like growth factor-I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance). Eur J Endocrinol 138:176–180
Laron Z, Sarel R (1970) Penis and testicular size in patients with growth hormone insufficiency. Acta Endocrinol 63:625–633
Laron Z, Pertzelan A, Karp M (1968) Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci 4:883–894
Laron Z, Arad J, Gurewitz R, Grunebaum M, Dickerman Z (1980a) Age at first conscious ejaculation: a milestone in male puberty. Helv Paediatr Acta 35:11–18
Laron Z, Sarel R, Pertzelan A (1980b) Puberty in Laron type dwarfism. Eur J Pediatr 134:79–83
Laron Z, Silbergeld A, Klinger B (1998) Hyperandrogenism induced by insulin-like growth factor-I (IGF-I) treatment of two girls with Laron syndrome. Child Hosp Q 10:75–79
Monget P, Bondy C (2000) Importance of the IGF system in early folliculogenesis. Mol Cell Endocrinol 163:89–93
Pertzelan A, Lazar L, Linger B, Laron Z (1993) Puberty in fifteen patients with Laron syndrome: a longitudinal study. In: Laron Z, Parks JS (eds) Lessons from Laron syndrome (LS) 1966-1992. Pediatric and Adolescent Endocrinology, vol. 24. Karger, Basel, pp 27–33
Prader A (1966) Testicular size: assessment and clinical importance. Triangle 7:240–243
Schonfeld WA, Beebe GW (1942) Normal growth and variation in male genitalia from birth to maturity. J Urol 48:759–777
Tanner JM, Whitehouse RH, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity and weight velocity. British children, 1965. Arch Dis Child 41: 454–471
Zilka E, Laron Z (1969) The normal testicular volume in Israeli children and adolescents. Harefuah 77:511–513
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Laron, Z., Kauli, R. (2011). Sexual Development in Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_10
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DOI: https://doi.org/10.1007/978-3-642-11183-9_10
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