Skip to main content
SpringerLink
Log in

Epidemiology of Kaposi Sarcoma

  • Chapter
  • First Online:
Skin Cancer - A World-Wide Perspective

  • 1232 Accesses

Abstract

Kaposi sarcoma (KS) is a spindle-cell tumor derived from endothelial cells, first described by a Hungarian dermatologist, Mortiz Kaposi [22]. KS is a very heterogeneous group of neoplasms that is usually divided with regard to its clinical and epidemiologic characteristics into four types [37]. Its classic or Mediterranean form tends to be benign. In transplant recipients it may be less so. As part of the AIDS pandemic, it may be life-threatening [35].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Agbaht, K., Pepedil, F., Kirkpantur, A., et al.: A case of Kaposi’s sarcoma following treatment of membranoproliferative glomerulonephritis and a review of the literature. Ren. Fail. 29, 107–110 (2007)

    Article  PubMed  CAS  Google Scholar 

  2. Alzahrani, A.J., El-Harith el, H.A., Milzer, J., et al.: Increased seroprevalence of human herpes virus-8 in renal transplant recipients in Saudi Arabia. Nephrol. Dial. Transplant. 20, 2532–2536 (2005)

    Article  PubMed  Google Scholar 

  3. Antman, K., Chang, Y.: Kaposi’s sarcoma. N. Engl. J. Med. 342, 1027–1038 (2000)

    Article  PubMed  CAS  Google Scholar 

  4. Antón, E.: Kaposi’s sarcoma in an immunocompetent patient following corticosteroid therapy. Eur. J. Intern. Med. 19, 226 (2008)

    Google Scholar 

  5. Athale, U.H., Patil, P.S., Chintu, C., et al.: Influence of HIV epidemic on the incidence of Kaposi’s sarcoma in Zambian children. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 8, 96–100 (1995)

    Article  PubMed  CAS  Google Scholar 

  6. Atkinson, J.O., Biggar, R.J., Goedert, J.J., et al.: The incidence of Kaposi sarcoma among injection drug users with AIDS in the United States. J. Acquir. Immune Defic. Syndr. 37, 1282–1287 (2004)

    Article  PubMed  Google Scholar 

  7. Ascoli, V., Zambon, P., Manno, D., et al.: Variability in the incidence of classic Kaposi’s sarcoma in the Veneto region, Northern Italy. Tumori 89, 122–124 (2003)

    PubMed  Google Scholar 

  8. Beral, V., Peterman, T.A., Berkelman, R.L., et al.: Kaposi’s sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335, 123–128 (1990)

    Article  PubMed  CAS  Google Scholar 

  9. Cook, P.M., Whitby, D., Calabro, M.L., et al.: Variability and evolution of Kaposi’s sarcoma-associated herpesvirus in Europe and Africa. International Collaborative Group. AIDS 13, 1165–1176 (1999)

    Article  PubMed  CAS  Google Scholar 

  10. Cottoni, F., Masala, M.V., Budroni, M., et al.: The role of occupation and a past history of malaria in the etiology of classic Kaposi’s sarcoma: a case-control study in north-east Sardinia. Br. J. Cancer. 76, 1518–1520 (1997)

    Article  PubMed  CAS  Google Scholar 

  11. Crispo, A., Tamburini, M., De Marco, M.R., et al.: HHV-8 prevalence, immunosuppression and Kaposi’s sarcoma in South Italy. Int. J. Mol. Med. 7, 535–538 (2001)

    PubMed  CAS  Google Scholar 

  12. Dal Maso, L., Polesel, J., Ascoli, V., et al.: Cancer and AIDS Registry Linkage Study. Classic Kaposi’s sarcoma in Italy, 1985–1998. Br. J. Cancer 92, 188–193 (2005)

    Article  PubMed  CAS  Google Scholar 

  13. Dourmishev, L.A., Dourmishev, A.L., Palmeri, D., et al.: Molecular genetics of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol. Mol. Biol. Rev. 67, 175–212 (2003)

    Article  PubMed  CAS  Google Scholar 

  14. Goedert, J.J.: The epidemiology of acquired immunodeficiency syndrome malignancies. Semin. Oncol. 27, 390–401 (2000)

    PubMed  CAS  Google Scholar 

  15. Grabar, S., Lanoy, E., Allavena, C., et al.: Clinical Epidemiology Group of the French Hospital Database on HIV. Causes of the first AIDS-defining illness and subsequent survival before and after the advent of combined antiretroviral therapy. HIV Med. 9, 246–256 (2008)

    Article  PubMed  CAS  Google Scholar 

  16. Grulich, A.E., Beral, V., Swerdlow, A.J.: Kaposi’s sarcoma in England and Wales before the AIDS epidemic. Br. J. Cancer 66, 1135–1137 (1992)

    Article  PubMed  CAS  Google Scholar 

  17. Hengge, U.R., Ruzicka, T., Tyring, S.K., et al.: Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy. Lancet Infect. Dis. 2, 281–292 (2002)

    Article  PubMed  Google Scholar 

  18. Hudnall, S.D., Rady, P.L., Tyring, S.K., et al.: Hydrocortisone activation of human herpesvirus 8 viral DNA replication and gene expression in vitro. Transplantation 67, 648–652 (1999)

    Article  PubMed  CAS  Google Scholar 

  19. Hussein, M.R.: Cutaneous and lymphadenopathic Kaposi’s sarcoma: a case report and review of literature. J. Cutan. Pathol. 35, 575–578 (2008)

    Article  PubMed  Google Scholar 

  20. Iscovich, J., Boffetta, P., Franceschi, S., et al.: Classic kaposi sarcoma: epidemiology and risk factors. Cancer 88, 500–517 (2000)

    Article  PubMed  CAS  Google Scholar 

  21. James, W., Berger, T., Eston, D.: Andrew’s diseases of the skin. Clinical dermatology, 10th edn. Saunders Elsevier, Philadelphia (2006)

    Google Scholar 

  22. Kaposi, M.: Idiopathisches multiples pigments arkom der haut. Arch. Dermatol. Syph. 4, 265–272 (1872)

    Google Scholar 

  23. Laor, Y., Schwartz, R.A.: Epidemiologic aspects of American Kaposi’s sarcoma. J. Surg. Oncol. 12, 299–303 (1979)

    Article  PubMed  CAS  Google Scholar 

  24. Meditz, A.L., Borok, M., MaWhinney, S., et al.: Gender differen-ces in AIDS-associated Kaposi sarcoma in Harare, Zimbabwe. J. Acquire. Immune Defic. Syndr. 44, 306–308 (2007)

    Article  Google Scholar 

  25. Mendez, J.C., Paya, C.V.: Kaposi’s Sarcoma and Transplantation. Herpes 7, 18–23 (2000)

    PubMed  Google Scholar 

  26. Micali, G., Gasparri, O., Nasca, M.R., et al.: Kaposi’s sarcoma occurring de novo in the surgical scar in a heart transplant recipient. J. Am. Acad. Dermatol. 27, 273–274 (1992)

    Article  PubMed  CAS  Google Scholar 

  27. Mohanna, S., Maco, V., Bravo, F., et al.: Epidemiology and clinical characteristics of classic Kaposi’s sarcoma, seroprevalence, and variants of human herpesvirus 8 in South America: a critical review of an old disease. Int. J. Infect. Dis. 9, 239–250 (2005)

    Article  PubMed  Google Scholar 

  28. Morand, J.J., Lightburn, E., Simon, F., et al.: Update on Kaposi’s sarcoma. Med. Trop. (Mars) 67, 123–130 (2007)

    CAS  Google Scholar 

  29. Penn, I.: Cancers following cyclosporine therapy. Transplant. Proc. 19, 2211–2213 (1987)

    PubMed  CAS  Google Scholar 

  30. Qunibi, W., Al-Furayh, O., Almeshari, K., et al.: Serologic association of human herpesvirus eight with posttransplant Kaposi’s sarcoma in Saudi Arabia. Transplantation 65, 583–585 (1998)

    Article  PubMed  CAS  Google Scholar 

  31. Renwick, N., Halaby, T., Weverling, G.J., et al.: Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi’s sarcoma. AIDS 12, 2481–2488 (1998)

    Article  PubMed  CAS  Google Scholar 

  32. Ruocco, V., Schwartz, R.A., Ruocco, E.: Lymphedema: an immunologically vulnerable site for development of neoplasms. J. Am. Acad. Dermatol. 47, 124–127 (2002)

    Article  PubMed  Google Scholar 

  33. Schulz, T.F.: Epidemiology of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8. Adv. Cancer Res. 76, 121–160 (1999)

    Article  PubMed  CAS  Google Scholar 

  34. Schwartz, R.A.: Kaposi’s sarcoma: advances and perspectives. J. Am. Acad. Dermatol. 34, 804–814 (1996)

    Article  PubMed  CAS  Google Scholar 

  35. Schwartz, R.A., Micali, G., Nasca, M.R., et al.: Kaposi sarcoma: a continuing conundrum. J. Am. Acad. Dermatol. 59, 179–206 (2008)

    Article  PubMed  Google Scholar 

  36. Stratigos, J.D., Katoulis, A.C., Stavrianeas, N.G.: An overview of classic Kaposi’s sarcoma in Greece. Adv. Exp. Med. Biol. 455, 503–506 (1999)

    Article  PubMed  CAS  Google Scholar 

  37. Szajerka, T., Jablecki, J.: Kaposi’s sarcoma revisited. AIDS Rev. 9, 230–236 (2007)

    PubMed  Google Scholar 

  38. Taylor, J.F., Smith, P.G., Bull, D., et al.: Kaposi’s sarcoma in Uganda: geographic and ethnic distribution. Br. J. Cancer 26, 483–497 (1973)

    Article  Google Scholar 

  39. Wabinga, H.R., Parkin, D.M., Wabwire-Mangen, F., et al.: Cancer in Kampala, Uganda, in 1989–91: changes in incidence in the era of AIDS. Int. J. Cancer 54, 26–36 (1993)

    Article  PubMed  CAS  Google Scholar 

  40. Yoshioka, M.C., Alchorne, M.M., Porro, A.M., et al.: Epidemiology of Kaposi’s sarcoma in patients with acquired immunodeficiency syndrome in São Paulo, Brazil. Int. J. Dermatol. 43, 643–647 (2004)

    Article  PubMed  Google Scholar 

  41. Zavos, G., Bokos, J., Papaconstantinou, I., et al.: Clinicopathological aspects of 18 Kaposi’s sarcoma among 1055 Greek renal transplant recipients. Artif. Organs. 28, 595–599 (2004)

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Tanta University, Tanta, Egypt

    Nagwa M. Elwan

Authors
  1. Nagwa M. Elwan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nagwa M. Elwan .

Editor information

Editors and Affiliations

  1. Dermatologische Klinik, Universitätsspital Zürich, Gloriastr. 31, Zürich, 8091, Switzerland

    Reinhard Dummer

  2. Mayo Clinic, Dept. Dermatology, Mayo Clinic College of Medicine, 1st St SW., 200, Rochester, 55905, Minnesota, USA

    Mark R. Pittelkow

  3. Graduate School of Medicine, Dentistry &, Pharmaceutical Sciences, Okayama University, Shikata-cho 2-5-1, Okayama, 700-8558, Japan

    Keiji Iwatsuki

  4. Royal Brisbane Hospital, Queensland Institute of Medical Research, Brisbane, 4029, Queensland, Australia

    Adèle Green

  5. Fac. Medicine, Dept. Dermatology, Tanta University, Tanta, Egypt

    Nagwa M. Elwan

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Elwan, N.M. (2010). Epidemiology of Kaposi Sarcoma. In: Dummer, R., Pittelkow, M., Iwatsuki, K., Green, A., Elwan, N. (eds) Skin Cancer - A World-Wide Perspective. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05072-5_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-05072-5_5

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05071-8

  • Online ISBN: 978-3-642-05072-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation