Abstract
Highly polarized cells like neurons use specialized RNA transport systems to allow for local control of RNA translation, which is a key to neuronal plasticity in the brain. Several proteins, like ZPB1, FMRP, and Staufen, play an important role in transporting RNA along dendrites to the synapse, and a growing amount of evidence has highlighted the role of miRNA in the control of local RNA translation. P-bodies (Processing bodies) are cytoplasmic structures involved in both RNA degradation and storage of untranslated mRNAs. In neurons, dendritic P-body-like structures (dlP-bodies) are present in the soma and dendrites, sometimes in proximity with synapses. They contain miRNA-repressed mRNA and display motorized movement. Under synaptic activation, dlP-bodies relocalize to more distant sites, exchange molecules with the surrounding cytoplasm, and lose some of their components. We propose a model in which dlP-bodies participate in the transport and local regulation of miRNA targets in the dendrites of mammalian neurons.
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Rage, F. (2010). Neuronal P-bodies and Transport of microRNA-Repressed mRNAs. In: De Strooper, B., Christen, Y. (eds) Macro Roles for MicroRNAs in the Life and Death of Neurons. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04298-0_6
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DOI: https://doi.org/10.1007/978-3-642-04298-0_6
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